8,907 research outputs found
A geometrical theory for {111} <hkl> recrystallisation texture formation in cold rolled IF steel
The introduction of a conditional deformating banding into BCC rolling texture modellling has produced a clue as too the origins of the {111} texture as it develops from the γ fibre material. OIM has reveqaled that deformation bands are present in many deformed γ grains, which therefore produced the gometrical condition for successful nucleation of rotated ND material by either subgrain growth or SIBM. Clearly the roles of solutes and precipitates have to be established in this deformation microstructure.published_or_final_versio
Combined Effect of Vorinostat and Grape Seed Proanthocyanidins on Modulation of Thymidine Phosphorylase in Non-Small Cell Lung Cancer
Purpose: To demonstrate the effect of histone deacetylase-inhibitor, vorinostat, on antitumour activity of grape seed proanthocyanidins (GSPs) in non-small cell lung cancer (NSCLC) cells.Methods: Expression of thymidine phosphorlase (TP) and thymidylate synthase (TS) was measured by real-time PCR and western blotting. TP knockdown was performed using specific small interfering RNA. Antitumour activity of combination of vorinostat and GSPs was assessed according to Chou and Talay method and by evaluating apoptosis.Results: Vorinostat treatment led to a significant increase in TP expression but decrease in TS expression in NSCLC cells. In H157 cells, increase in the concentration of vorinostat from 0.34 to 0.4 μM increased TP expression 3- to 6-fold. In H1299 cells, there was 7-fold reduction of TS transcript and 30-fold increase of TP transcript at 48 h. Vorinostat, when used in combination with GSPs, resulted in a synergistic anti-proliferative effect and increased apoptotic cell death. However, cells with TP knockdown did not exhibit vorinostat- and GSPs-mediated anti-proliferative effect and apoptotic cell death.Conclusion: The combination of vorinostat and GSPs can be an effective and innovative antitumour therapy for the treatment of NSCLC.Keywords: Histone deacetylase-inhibitor, Synergism, Apoptosis, Antitumo
Sub-6GHz 4G/5G Conformal Glasses Antennas
© 2013 IEEE. The difficulty of antenna design applied to glasses is that the structure of glasses is too single, and the space available for antenna design is greatly limited. In this background, the integrated design of 4G antennas and 5G antennas applied to glasses is proposed in this paper. The most important highlight of this design is that it makes full use of the limited three-dimensional space structure provided by glasses and achieves the perfect combination of the antenna and glasses in the physical structure. Specifically, two antennas for 4G communication are arranged on two glasses frames, and four antennas for 5G communication are arranged on two glasses legs. In this way, we can make full use of the space provided by the glasses to design antennas and ensure that there is a certain distance between the 4G antennas and 5G antennas so that the performance of both 4G antennas and 5G antennas can be guaranteed. The 4G antenna consists of a loop structure printed on the frame and leg of the glasses and a parasitic branch strip printed on the front of the leg of the glasses. The resonance modes of the 4G antenna are mainly loop, monopole, and dipole modes, which can cover two 4G bands of 0.824-0.96 GHz and 1.71-2.69 GHz. Each 5G antenna mainly comes from the open slot mode etched on the metal ground surface of an FR4 substrate of the glasses leg. In addition, the slot antennas operate in two 5G bands of 3.3-3.6 GHz and 4.8-5.0 GHz. Finally, the glasses and the antennas are fabricated based on FR4 substrates and measured. The measured results show that the proposed antennas perform well and have the potential to be used in 4G/5G communications through glasses
Effects of single-trial averaging on spatial extent of brain activation detected by fMRI are subject and task dependent
Generalization of hyperbolic perturbation solution for heteroclinic orbits of strongly nonlinear self-excited oscillator
A generalized hyperbolic perturbation method for heteroclinic solutions is presented for strongly nonlinear self-excited oscillators in the more general form of x⋅⋅+g(x)=ɛf(μ,x,x⋅)x··+g(x)=ɛf(μ,x,x·). The advantage of this work is that heteroclinic solutions for more complicated and strong nonlinearities can be analytically derived, and the previous hyperbolic perturbation solutions for Duffing type oscillator can be just regarded as a special case of the present method. The applications to cases with quadratic-cubic nonlinearities and with quintic-septic nonlinearities are presented. Comparisons with other methods are performed to assess the effectiveness of the present method.postprin
The Directed Dominating Set Problem: Generalized Leaf Removal and Belief Propagation
A minimum dominating set for a digraph (directed graph) is a smallest set of
vertices such that each vertex either belongs to this set or has at least one
parent vertex in this set. We solve this hard combinatorial optimization
problem approximately by a local algorithm of generalized leaf removal and by a
message-passing algorithm of belief propagation. These algorithms can construct
near-optimal dominating sets or even exact minimum dominating sets for random
digraphs and also for real-world digraph instances. We further develop a core
percolation theory and a replica-symmetric spin glass theory for this problem.
Our algorithmic and theoretical results may facilitate applications of
dominating sets to various network problems involving directed interactions.Comment: 11 pages, 3 figures in EPS forma
Genetic transformation of Physcomitrella patens mediated by Agrobacterium tumefaciens
A simple efficient protocol for introducing exogenous gene from Agrobacterium tumfaciens into Physcomitrella patens was established. When the gametophores of gametophytes about 12 leaves wereinoculated into the wells of PP3 medium at 25°C under the continuous light energy of 30 mol m-2 s-1 from cool-white fluorescent lamps, they grew up to form many buds at about 11 days, then A. tumefaciens at OD600 0.3 was added into the whole wells for 4 times at an interval of 12 h for continuous co-cultivation. After about 17 days of co-culture, the new juvenile gametophytes about 12 leaves grew up and were incubated into PP3 medium containing 50 mg L-1 kanamycin for selection. 100% positiveplants could be obtained after 4 generations of selective culture. PCR analysis showed that gene Cameleon YC2.1 in A. tumefaciens was transferred into all detected plants of P. patens and southern blotting analysis confirmed that exogenous gene was integrated into genomic DNA at a single locus. The results facilitated to analyze genes from more plants via genetic transformation by this system
Comparison of three topologies for VRM fast transient application
This paper compares three topologies for voltage regulator module VRM for fast transient application. The topologies are the most popular multi-phase converter, a synchronous rectifier buck converter topology and a recently introduced new stepping inductor converter. Analysis and simulation show that the stepping inductor topology gives the fastest response with minimal amount of output filter capacitance.published_or_final_versio
Loss analysis of a single phase fast transient VRM converter
This paper analyzes the losses of a stepping inductor converter in the presence of load transients. Stepping inductor converter is a buck VRM topology which only employs a single phase. Stepping inductor converter is very effective in dealing with fast transient and at the same time it can give better steady state efficiency. Occurrences of transient load current changes are measured in a PC and data are used for the comparison to evaluate the real world performance of the stepping inductor converter and the multiphase interleaved buck converter.published_or_final_versio
Scaling on hysteresis dispersion in ferroelectric systems
Author name used in this publication: Z. G. LiuAuthor name used in this publication: N. B. MingAuthor name used in this publication: H. L. W. ChanAuthor name used in this publication: C. L. Choy2000-2001 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
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