Detection of Laplace-resonant three-planet systems from transit timing variations

Transit timing variations (TTVs) are useful to constrain the existence of perturbing planets, especially in resonant systems where the variations are strongly enhanced. Here we focus on Laplace-resonant three-planet systems, and assume the inner planet transits the star. A dynamical study is performed for different masses of the three bodies, with a special attention to terrestrial planets. We consider a maximal time-span of ~ 100 years and discuss the shape of the inner planet TTVs curve. Using frequency analysis, we highlight the three periods related to the evolution of the system: two periods associated with the Laplace-resonant angle and the third one with the precession of the pericenters. These three periods are clearly detected in the TTVs of an inner giant planet perturbed by two terrestrial companions. Only two periods are detected for a Jupiter-Jupiter-Earth configuration (the ones associated with the giant interactions) or for three terrestrial planets (the Laplace periods). However, the latter system can be constrained from the inner planet TTVs. We finally remark that the TTVs of resonant three or two Jupiter systems mix up, when the period of the Laplace resonant angle matches the pericenter precession of the two-body configuration. This study highlights the importance of TTVs long-term observational programs for the detection of multiple-planet resonant systems.Comment: 8 pages, 8 figures, accepted in MNRA

A general introduction to glucocorticoid biology

Glucocorticoids (GCs) are steroid hormones widely used for the treatment of inflammation, autoimmune diseases, and cancer. To exert their broad physiological and therapeutic effects, GCs bind to the GC receptor (GR) which belongs to the nuclear receptor superfamily of transcription factors. Despite their success, GCs are hindered by the occurrence of side effects and glucocorticoid resistance (GCR). Increased knowledge on GC and GR biology together with a better understanding of the molecular mechanisms underlying the GC side effects and GCR are necessary for improved GC therapy development. We here provide a general overview on the current insights in GC biology with a focus on GC synthesis, regulation and physiology, role in inflammation inhibition, and on GR function and plasticity. Furthermore, novel and selective therapeutic strategies are proposed based on recently recognized distinct molecular mechanisms of the GR. We will explain the SEDIGRAM concept, which was launched based on our research results

Taking Chemical EOR Data from Lab Results to Simulation

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Origin and continuation of 3/2, 5/2, 3/1, 4/1 and 5/1 resonant periodic orbits in the circular and elliptic restricted three-body problem

We consider a planetary system consisting of two primaries, namely a star and a giant planet, and a massless secondary, say a terrestrial planet or an asteroid, which moves under their gravitational attraction. We study the dynamics of this system in the framework of the circular and elliptic restricted TBP, when the motion of the giant planet describes circular and elliptic orbits, respectively. Originating from the circular family, families of symmetric periodic orbits in the 3/2, 5/2, 3/1, 4/1 and 5/1 mean-motion resonances are continued in the circular and the elliptic problems. New bifurcation points from the circular to the elliptic problem are found for each of the above resonances and thus, new families, continued from these points are herein presented. Stable segments of periodic orbits were found at high eccentricity values of the already known families considered as whole unstable previously. Moreover, new isolated (not continued from bifurcation points) families are computed in the elliptic restricted problem. The majority of the new families mainly consist of stable periodic orbits at high eccentricities. The families of the 5/1 resonance are investigated for the first time in the restricted three-body problems. We highlight the effect of stable periodic orbits on the formation of stable regions in their vicinity and unveil the boundaries of such domains in phase space by computing maps of dynamical stability. The long-term stable evolution of the terrestrial planets or asteroids is dependent on the existence of regular domains in their dynamical neighbourhood in phase space, which could host them for long time spans. This study, besides other celestial architectures that can be efficiently modelled by the circular and elliptic restricted problems, is particularly appropriate for the discovery of terrestrial companions among the single-giant planet systems discovered so far.Comment: Accepted for publication in Celestial Mechanics and Dynamical Astronom

Puzzling out the coexistence of terrestrial planets and giant exoplanets. The 2/1 resonant periodic orbits

Hundreds of giant planets have been discovered so far and the quest of exo-Earths in giant planet systems has become intriguing. In this work, we aim to address the question of the possible long-term coexistence of a terrestrial companion on an orbit interior to a giant planet, and explore the extent of the stability regions for both non-resonant and resonant configurations. Our study focuses on the restricted three-body problem, where an inner terrestrial planet (massless body) moves under the gravitational attraction of a star and an outer massive planet on a circular or elliptic orbit. Using the Detrended Fast Lyapunov Indicator as a chaotic indicator, we constructed maps of dynamical stability by varying both the eccentricity of the outer giant planet and the semi-major axis of the inner terrestrial planet, and identify the boundaries of the stability domains. Guided by the computation of families of periodic orbits, the phase space is unravelled by meticulously chosen stable periodic orbits, which buttress the stability domains. We provide all possible stability domains for coplanar symmetric configurations and show that a terrestrial planet, either in mean-motion resonance or not, can coexist with a giant planet, when the latter moves on either a circular or an (even highly) eccentric orbit. New families of symmetric and asymmetric periodic orbits are presented for the 2/1 resonance. It is shown that an inner terrestrial planet can survive long time spans with a giant eccentric outer planet on resonant symmetric orbits, even when both orbits are highly eccentric. For 22 detected single-planet systems consisting of a giant planet with high eccentricity, we discuss the possible existence of a terrestrial planet. This study is particularly suitable for the research of companions among the detected systems with giant planets, and could assist with refining observational data.Comment: Accepted for publication in A&

Predicting links in ego-networks using temporal information

Link prediction appears as a central problem of network science, as it calls for unfolding the mechanisms that govern the micro-dynamics of the network. In this work, we are interested in ego-networks, that is the mere information of interactions of a node to its neighbors, in the context of social relationships. As the structural information is very poor, we rely on another source of information to predict links among egos' neighbors: the timing of interactions. We define several features to capture different kinds of temporal information and apply machine learning methods to combine these various features and improve the quality of the prediction. We demonstrate the efficiency of this temporal approach on a cellphone interaction dataset, pointing out features which prove themselves to perform well in this context, in particular the temporal profile of interactions and elapsed time between contacts.Comment: submitted to EPJ Data Scienc

On the 3D secular dynamics of radial-velocity-detected planetary systems

Aims. To date, more than 600 multi-planetary systems have been discovered. Due to the limitations of the detection methods, our knowledge of the systems is usually far from complete. In particular, for planetary systems discovered with the radial velocity (RV) technique, the inclinations of the orbital planes, and thus the mutual inclinations and planetary masses, are unknown. Our work aims to constrain the spatial configuration of several RV-detected extrasolar systems that are not in a mean-motion resonance. Methods. Through an analytical study based on a first-order secular Hamiltonian expansion and numerical explorations performed with a chaos detector, we identified ranges of values for the orbital inclinations and the mutual inclinations, which ensure the long-term stability of the system. Our results were validated by comparison with n-body simulations, showing the accuracy of our analytical approach up to high mutual inclinations (approx. 70{\deg}-80{\deg}). Results. We find that, given the current estimations for the parameters of the selected systems, long-term regular evolution of the spatial configurations is observed, for all the systems, i) at low mutual inclinations (typically less than 35{\deg}) and ii) at higher mutual inclinations, preferentially if the system is in a Lidov-Kozai resonance. Indeed, a rapid destabilisation of highly mutually inclined orbits is commonly observed, due to the significant chaos that develops around the stability islands of the Lidov-Kozai resonance. The extent of the Lidov-Kozai resonant region is discussed for ten planetary systems (HD 11506, HD 12661, HD 134987, HD 142, HD 154857, HD 164922, HD 169830, HD 207832, HD 4732, and HD 74156).Comment: Accepted for publication in A&