Analisis Portofolio Optimal Dengan Single Index Model Untuk Meminimumkan Risiko Bagi Investor Di Bursa Efek Indonesia (Studi Pada Saham Indeks Kompas 100 Periode Februari 2010-juli 2014)

Investments can be made in the capital market, capital market instruments which are mostly attractive for investors is stock. Stock provides a return in the form of capital gains and dividends yield, not only noticing the return, investors need to pay attention to the investments risk. Unsystematis risk can be minimized by forming the optimal portfolio using one of the methods that is single index model. Study purpose is to knowing the stocks forming the optimal portfolio, the proportion of funds allocated to each stocks, the level of expectation return and risk.The method used in this research is descriptive research method with a quantitative approach. The samples used were 46 stocks in Kompas 100 Index, which meets the criteria for sampling. The results showed that 12 stocks of forming optimal portfolio, the stocks of which are UNVR, TRAM, MNCN, BHIT, JSMR, BMTR, GJTL, KLBF, AALI, CPIN, AKRA, and ASRI. Stock with highest proportion of funds is TRAM (23,52%), stock with lowest proportion of funds is AALI (0,62%). Portfolio which are formed will give return expectations by 3,05477% and carry the risk for about 0,1228%

Table1_METTL3 promotes drug resistance to oxaliplatin in gastric cancer cells through DNA repair pathway.DOCX

Gastric cancer (GC) poses a significant threat to human health and remains a prevalent form of cancer. Despite clinical treatments, the prognosis for Gastric cancer patients is still unsatisfactory, largely due to the development of multidrug resistance. Oxaliplatin (OXA), a second-generation platinum drug, is commonly recommended for adjuvant and palliative chemotherapy in Gastric cancer; however, the underlying mechanisms of acquired resistance to Oxaliplatin in Gastric cancer patients are not yet fully understood. In this study, we aimed to explore the potential mechanisms of Oxaliplatin resistance in Gastric cancer by employing bioinformatics analysis and conducting in vitro experiments. Specifically, we focused on investigating the role of methyltransferase-like 3 (METTL3). Our findings revealed that the knockdown of METTL3 significantly impeded the proliferation and migration of Gastric cancer cells. METTL3 knockdown induced apoptosis in OXA-resistant Gastric cancer cells and enhanced their sensitivity to Oxaliplatin. Furthermore, we found that DNA repair pathways were significantly activated in OXA-resistant Gastric cancer cells, and METTL3 knockdown significantly inhibited DNA repair pathways. Another important finding is that METTL3 knockdown and OXA-induced Gastric cancer cell death are additive, and the targeted METTL3 can assist Oxaliplatin treatment. Collectively, our findings suggest that METTL3 knockdown can augment the sensitivity of Gastric cancer cells to Oxaliplatin by impeding DNA repair processes. Consequently, targeting METTL3 holds great promise as a viable adjuvant strategy in the treatment of Gastric cancer patients.</p

Copper-Nanoparticle-Induced Porous Si/Cu Composite Films as an Anode for Lithium Ion Batteries

“Welcome-mat”-like porous Si/Cu composite amorphous films are fabricated by applying the predeposited Cu-nanoparticle-assembled film as the growth direction template for the subsequent deposition of a Si active layer with the cluster beam deposition technique. When used as the binder-free anodes for lithium ion batteries, the acquired single-layer porous Si/Cu composite film exhibits a large reversible capacity of 3124 mA h g^–1 after 1000 cycles at 1 A g^–1. Even when cycled at 20 A g^–1 for 450 cycles, the porous Si/Cu composite film still delivers a decent reversible capacity of 2086 mA h g^–1. Also, multilayer porous Si/Cu composite films are synthesized through layer-by-layer sputtering and exhibit outstanding cyclability and relatively high specific capacity and initial Coulombic efficiency irrespective of increasing the layer number from two to four layers. The reasons for the excellent electrochemical properties of single-layer and multilayer porous Si/Cu composite films are discussed in detail

Relationship between the TRIM24 expression and the clinicopathological factors.

<p><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0085462#pone-0085462-t001" target="_blank">Table 1:</a> a. Missing data for 2 patients. b. Missing data for 3 patients. c. Missing data for 1 patient. d. Missing data for 10 patients; 7 patients were excluded according to the inclusion criteria. *.We defined that those patients whose recurrence time is less than 6 months as intrahepatic metastasis.</p

Depletion of TRIM24 inhibits the process of EMT.

<p>5(A). Western blotting analysis of the cell-apoptosis related proteins showed the expression of E-cadherin was increased and Snail, Slug, Vimentin, andβ-catenin were decreased after knockdown TRIM24 in HepG2 cells; 5(B). Reduced migration and invasion ability of HepG2 cells at 48 h post-transfection with siTRIM24 (P<0.05, compared with controls).</p

Immunohistochemical staining of TRIM24 in tissue sections.

<p>A. Negative staining in normal liver tissue. B. Negative staining in benign liver lesions tissues (Hepatic hemangioma). C. Negative TRIM24 staining in an AFP>400 ug/L, well differentiated HCC tissue. D. Positive TRIM24 staining in an AFP<400 ug/L, moderate differentiated HCC tissue. E. Negative TRIM24 staining in an AFP<400 ug/L,well differentiated HCC tissue. F&G. Positive TRIM24 staining in an AFP>400 ug/L, poor differentiated HCC tissue. H. Negative control using antibody diluent.</p

The Kaplan-Meier survival curves of patients with positive TRIM24 expression and negative TRIM24 expression.

<p>The Kaplan-Meier survival curves of patients with positive TRIM24 expression and negative TRIM24 expression.</p

Depletion of TRIM24 reduces cell proliferation.

<p>4(A). Western blotting analysis of the cell-cycle related proteins showed the expression of Cyclin D1 and CDK4 were decreased but showed no significant change in p21 after knockdown TRIM24 in HepG2 cells; 4(B). Cell cycle analyses showed that the percentage of G1 phase was increased in siTRIM24 group (P<0.05), whereas the percentages of S phase (P<0.05) and G2 phase (P<0.05) were decreased in the TRIM24 knockdown cells compared with control cells; 4(C) CCK-8 assay suggested that cell proliferation of HepG2 after TRIM24 silencing was reduced compared with the control group.</p

Enhanced Microwave Absorption Properties by Tuning Cation Deficiency of Perovskite Oxides of Two-Dimensional LaFeO₃/C Composite in X‑Band

Development of microwave absorption materials with tunable thickness and bandwidth is particularly urgent for practical applications but remains a great challenge. Here, two-dimensional nanocomposites consisting of perovskite oxides (LaFeO₃) and amorphous carbon were successfully obtained through a one pot with heating treatment using sodium chloride as a hard template. The tunable absorption properties were realized by introducing A-site cation deficiency in LaFeO₃ perovskite. Among the A-site cation-deficient perovskites, La_0.62FeO₃/C (L_0.62FOC) has the best microwave absorption properties in which the maximum absorption is −26.6 dB at 9.8 GHz with a thickness of 2.94 mm and the bandwidth range almost covers all X-band. The main reason affecting the microwave absorption performance was derived from the A-site cation deficiency which induced more dipoles polarization loss. This work proposes a promising method to tune the microwave absorption performance via introducing deficiency in a crystal lattice

Wild Panax plants adapt to their thermal environment by harboring abundant beneficial seed endophytic bacteria

The seed microbiome of crop wild relatives is a potential reservoir of beneficial traits that potentially improve their host plant resilience to fluctuating environments and pathogenic threats. Herein, we studied the seed microbiome of three species of the medicinal genus Panax (P. vietnamensis, P. japonicas, and P. stipuleanatus) collected from seven locations in Southwest China. We used qPCR and metabarcoding high-throughput sequencing to target both endophytic bacteria and fungi. Seed bacterial absolute abundance (1.1 × 109∼1.0 × 107 gene copy numbers per gram seed) was substantially higher than that of fungi (7.6 × 105∼3.7 × 102). Host plant genotype was the main driver of seed microbiome composition for both bacteria and fungi. Panax growing hypothermal environments significantly shaped their seed endophytic bacterial but not fungal microbiota. The three Panax species’ seeds harbored unique microbes [averaged ∼150 amplicon sequence variants (ASVs)], sharing only 12 bacterial ASVs (half affiliated to Halomonas) and four fungal ASVs. Network analysis showed that the Panax seed endophytic bacteria tend to form inter-weaved functional modules that are majorly connected by core members from the genus Halomonas, Pseudomonas, and Pantoea. These genera have been associated with nutrient cycling, plant, disease suppression, and tolerance to environmental fluctuation. Together, these novel insights may shade light on the ecological strategies of wild Panax plants adaptation to their thermal environment by possessing abundant beneficial seed endophytic bacteria.</p