The search for extraterrestrial intelligence: Telecommunications technology

Efforts to discover evidence of intelligent extraterrestrial life have become not only feasible, but respectable. Fledgling observational projects have begun that will use state-of-the-art hardware to develop sophisticated receiving and data processing systems. The rationale behind the Search for Extraterrestrial Intelligence, the manner in which the program is taking shape, and the implications for telecommunications are described. It is concluded that the breadth of technological development required for the detection of signals from galactic brethren has particular relevance for the future of telecommunications in Earth oriented uses

Development of advanced digital techniques for data acquisition processing and communication Interim scientific report

Image correlation and computerized simulation applied to data acquisition and imaging technique

Assembly, trafficking and function of gamma-secretase

gamma-Secretase catalyzes the final cleavage of the beta-amyloid precursor protein to generate amyloid-beta peptide, the principal component of amyloid plaques in the brains of patients suffering from Alzheimer's disease. Here, we review the identification of gamma-secretase as a protease complex and its assembly and trafficking to its site(s) of cellular function. In reconstitution experiments, gamma-secretase was found to be composed of four integral membrane proteins, presenilin (PS), nicastrin (NCT), PEN-2 and APH-1 that are essential and sufficient for gamma-secretase activity. PS, which serves as a catalytic subunit of gamma-secretase, was identified as a prototypic member of novel aspartyl proteases of the GxGD type. In human cells, gamma-secretase could be further defined as a heterogeneous activity consisting of distinct complexes that are composed of PS1 or PS2 and APH-1a or APH-1b homologues together with NCT and PEN-2. Using green fluorescent protein as a reporter we localized PS and gamma-secretase activity at the plasma membrane and endosomes. Investigation of gamma-secretase complex assembly in knockdown and knockout cells of the individual subunits allowed us to develop a model of complex assembly in which NCT and APH-1 first stabilize PS before PEN-2 assembles as the last component. Furthermore, we could map domains in PS and PEN-2 that govern assembly and trafficking of the complex. Finally, Rer1 was identified as a PEN-2-binding protein that serves a role as an auxiliary factor for gamma-secretase complex assembly. Copyright (c) 2006 S. Karger AG, Basel

The production of BeV potential wells

Production of billion electron volt potential wells by cloud of electrons suspended in magnetic fiel

QUASAT: An orbiting very long baseline interferometer program using large space antenna systems

QUASAT, which stands for QUASAR SATELLITE, is the name given to a new mission being studied by NASA. The QUASAT mission concept involves a free flying Earth orbiting large radio telescope, which will observe astronomical radio sources simultaneously with ground radio telescopes. The primary goal of QUASAT is to provide a system capable of collecting radio frequency data which will lead to a better understanding of extremely high energy events taking place in a variety of celestial objects including quasars, galactic nuclei, interstellar masers, radio stars and pulsars. QUASAT's unique scientific contribution will be the increased resolution in the emission brightness profile maps of the celestial objects

Probabilistic Cross-Identification of Astronomical Sources

We present a general probabilistic formalism for cross-identifying astronomical point sources in multiple observations. Our Bayesian approach, symmetric in all observations, is the foundation of a unified framework for object matching, where not only spatial information, but physical properties, such as colors, redshift and luminosity, can also be considered in a natural way. We provide a practical recipe to implement an efficient recursive algorithm to evaluate the Bayes factor over a set of catalogs with known circular errors in positions. This new methodology is crucial for studies leveraging the synergy of today's multi-wavelength observations and to enter the time-domain science of the upcoming survey telescopes.Comment: Accepted for publication in the Astrophysical Journal, 8 pages, 1 figure, emulateapj w/ apjfont