“John the Astonishing”

To add greatly to astonishment over the career of John of Rupescissa, whom I have begun to think of after more than thirty years of research on his life and thought as “John the Astonishing”, comes the unexpected discovery of an astonishing new treatise. The following are merely some preliminary remarks about some aspects of the Sexdequiloquium that I find particularly remarkable. Amazing productivityI begin with implications it brings regarding Rupescissa’s prison-bound productivity. In her ..

“John the Astonishing”

To add greatly to astonishment over the career of John of Rupescissa, whom I have begun to think of after more than thirty years of research on his life and thought as “John the Astonishing”, comes the unexpected discovery of an astonishing new treatise. The following are merely some preliminary remarks about some aspects of the Sexdequiloquium that I find particularly remarkable. Amazing productivityI begin with implications it brings regarding Rupescissa’s prison-bound productivity. In her ..

Yet Another Work by John of Rupescissa

Identification d’un nouveau traité de Jean de Roquetaillade, Verba fratris Johannis de Rupescissa, qui reformule le contenu du Vademecum in tribulationeIdentificazione di un nuovo trattato di Giovanni di Rupescissa, Verba fratris Johannis de RupescissaIdentification of a new treatise by John of Rupescissa, Verba fratris Johannis de Rupescissa, being a reconsideration of the Vademecum in tribulation

Selective Bibliography of Studies and Editions of High and Late Medieval Latin Eschatological Prophecies

The study of medieval Latin eschatology has benefited over the past decades from an increasing number of scholars who are contributing to our knowledge of the history, personalities, and writings connected to prophetic thought. For the individual researcher, it means there is a wider range of texts and arguments to master. The following bibliography is not meant to be comprehensive; it is a guide to help orient researchers towards recent studies that provide editions of texts, engage in the c..

Notes bibliographiques (2002-2004)

Généralités Uscirà nel febbraio 2004 il primo numero di Rivista di storia del cristianesimo. Si tratta di una nuova rivista storica con cadenza semestrale, pubblicata dalle edizioni Morcelliana di Brescia e guidata da un Comitato di redazione di cui fanno parte M. Caffiero, G. Filoramo, D. Menozzi, E. Norelli, G. L. Potestà, R. Rusconi. Filoramo e Menozzi ne sono codirettori. Si segnala il primo numero perché contiene una sezione intitolata : « Testualità simboliche e profetiche : da Gioacchi..

Notes bibliographiques (2002-2004)

Généralités Uscirà nel febbraio 2004 il primo numero di Rivista di storia del cristianesimo. Si tratta di una nuova rivista storica con cadenza semestrale, pubblicata dalle edizioni Morcelliana di Brescia e guidata da un Comitato di redazione di cui fanno parte M. Caffiero, G. Filoramo, D. Menozzi, E. Norelli, G. L. Potestà, R. Rusconi. Filoramo e Menozzi ne sono codirettori. Si segnala il primo numero perché contiene una sezione intitolata : « Testualità simboliche e profetiche : da Gioacchi..

Intravesical rAd-IFNα/Syn3 for Patients With High-Grade, Bacillus Calmette-Guerin-Refractory or Relapsed Non-Muscle-Invasive Bladder Cancer: A Phase II Randomized Study.

Purpose Many patients with high-risk non-muscle-invasive bladder cancer (NMIBC) are either refractory to bacillus Calmette-Guerin (BCG) treatment or may experience disease relapse. We assessed the efficacy and safety of recombinant adenovirus interferon alfa with Syn3 (rAd-IFNα/Syn3), a replication-deficient recombinant adenovirus gene transfer vector, for patients with high-grade (HG) BCG-refractory or relapsed NMIBC. Methods In this open-label, multicenter (n = 13), parallel-arm, phase II study ( ClinicalTrials.gov identifier: NCT01687244), 43 patients with HG BCG-refractory or relapsed NMIBC received intravesical rAd-IFNα/Syn3 (randomly assigned 1:1 to 1 × 10(11) viral particles (vp)/mL or 3 × 10(11) vp/mL). Patients who responded at months 3, 6, and 9 were retreated at months 4, 7, and 10. The primary end point was 12-month HG recurrence-free survival (RFS). All patients who received at least one dose were included in efficacy and safety analyses. Results Forty patients received rAd-IFNα/Syn3 (1 × 10(11) vp/mL, n = 21; 3 × 10(11) vp/mL, n = 19) between November 5, 2012, and April 8, 2015. Fourteen patients (35.0%; 90% CI, 22.6% to 49.2%) remained free of HG recurrence 12 months after initial treatment. Comparable 12-month HG RFS was noted for both doses. Of these 14 patients, two experienced recurrence at 21 and 28 months, respectively, after treatment initiation, and one died as a result of an upper tract tumor at 17 months without a recurrence. rAd-IFNα/Syn3 was well tolerated; no grade four or five adverse events (AEs) occurred, and no patient discontinued treatment because of an adverse event. The most frequently reported drug-related AEs were micturition urgency (n = 16; 40%), dysuria (n = 16; 40%), fatigue (n = 13; 32.5%), pollakiuria (n = 11; 28%), and hematuria and nocturia (n = 10 each; 25%). Conclusion rAd-IFNα/Syn3 was well tolerated. It demonstrated promising efficacy for patients with HG NMIBC after BCG therapy who were unable or unwilling to undergo radical cystectomy

Genome analysis of a simultaneously predatory and prey-independent, novel Bdellovibrio bacteriovorus from the River Tiber, supports in silico predictions of both ancient and recent lateral gene transfer from diverse bacteria

Background: Evolution equipped Bdellovibrio bacteriovorus predatory bacteria to invade other bacteria, digesting and replicating, sealed within them thus preventing nutrient-sharing with organisms in the surrounding environment. Bdellovibrio were previously described as “obligate predators” because only by mutations, often in gene bd0108, are 1 in ~1x107 of predatory lab strains of Bdellovibrio converted to prey-independent growth. A previous genomic analysis of B. bacteriovorus strain HD100 suggested that predatory consumption of prey DNA by lytic enzymes made Bdellovibrio less likely than other bacteria to acquire DNA by lateral gene transfer (LGT). However the Doolittle and Pan groups predicted, in silico, both ancient and recent lateral gene transfer into the B. bacteriovorus HD100 genome. Results: To test these predictions, we isolated a predatory bacterium from the River Tiber- a good potential source of LGT as it is rich in diverse bacteria and organic pollutants- by enrichment culturing with E. coli prey cells. The isolate was identified as B. bacteriovorus and named as strain Tiberius. Unusually, this Tiberius strain showed simultaneous prey-independent growth on organic nutrients and predatory growth on live prey. Despite the prey-independent growth, the homolog of bd0108 did not have typical prey-independent-type mutations. The dual growth mode may reflect the high carbon content of the river, and gives B. bacteriovorus Tiberius extended non-predatory contact with the other bacteria present. The HD100 and Tiberius genomes were extensively syntenic despite their different cultured-terrestrial/freshly-isolated aquatic histories; but there were significant differences in gene content indicative of genomic flux and LGT. Gene content comparisons support previously published in silico predictions for LGT in strain HD100 with substantial conservation of genes predicted to have ancient LGT origins but little conservation of AT-rich genes predicted to be recently acquired. Conclusions: The natural niche and dual predatory, and prey-independent growth of the B. bacteriovorus Tiberius strain afforded it extensive non-predatory contact with other marine and freshwater bacteria from which LGT is evident in its genome. Thus despite their arsenal of DNA-lytic enzymes; Bdellovibrio are not always predatory in natural niches and their genomes are shaped by acquiring whole genes from other bacteria

Toward a Socialism for the Future, in the Wake of the Demise of the Socialism of the Past

http://deepblue.lib.umich.edu/bitstream/2027.42/51230/1/464.pd