Torsion of the Gallbladder

A 77-year-old woman was seen with progressive abdominal pain. A CT scan was made and showed a large gallbladder extending into the right lower abdomen. Ultrasound was performed but demonstrated no gallstones. Laparoscopy showed a tordated, necrotic gallbladder that was attached to the liver only by the cystic artery and cystic duct. Cholecystectomy was performed. Torsion of the gallbladder is a rare but clinically important condition in which the diagnosis seldom is made preoperatively. In radiological and clinical signs of cholecystitis without gallstones, this condition should be considered

Effect of pharmacogenetics on medicine

Pharmacogenetics is moving rapidly to assemble a large set of polymorphisms that define the influence of genetic diversity on human drug response. Scientific and technological advances of the last 10 years have led to new approaches to the discovery of genetic drug susceptibility loci, the development of high-tech analytical strategies for drug susceptibility profiling, and a flood of new gene discoveries in the area of receptors and receptor polymorphisms. Extension and refinement of our knowledge of human genetic diversity is essential to the use of drugs in more of an individualized manner and to the discovery of better therapies, but knowledge of the functional consequences of this diversity, the next great challenge in pharmacogenetics, provides the best chance to profit from this diversity. Environ. Mol. Mutagen. 37:179–184,2001. © 2001 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/35018/1/1026_ftp.pd

How a Failed Astrophysics Major Became a Successful Science Writer

Presented on March 12, 2019 in the Clough Undergraduate Learning Commons, Room 152.Michael D. Lemonick is the Opinion Editor at Scientific American. He has written more than 50 Time magazine cover stories on science, and has written for National Geographic, The New Yorker and other publications.Runtime: 61:12 minutesI knew from the time I was a very young child that I wanted to be an astronomer. The dream lasted until I got to college, where I learned to my dismay that I actually had no passion for doing what an astronomer does; what I really wanted is to know what an astronomer knows. This is the story of how it all worked out

Light at the edge of the universe: dispatches from the front lines of cosmology

Will the universe expand forever? Or will it collapse in a Big Crunch within the next few billion years? If the Big Bang theory is correct in presenting the origins of the universe as a smooth fireball, how did the universe come to contain structures as large as the recently discovered ""Great Wall"" of galaxies, which stretches hundreds of millions of light years? Such are the compelling questions that face cosmologists today, and it is the excitement and wonder of their research that Michael Lemonick shares in this lively tour of the current state of astrophysics and cosmology. Here we vi