Historical and Regional Pronunciations in Vocal Performance

RILM: Particular pronunciations or dialects are important factors in the creation and execution of vocal music. Such sounds can have a dramatic effect on the coloration and rhythmic profile of a piece of music; the recreation of such sounds is thus of great importance

Early Recordings and Musical Style: Chaning Tastes in Instrumental Performance, 1900-1950. By Robert Philip

Leedy discusses and reviews Philip\u27s 1992 book

Singing in Latin, or, Pronunciation explor\u27d. By Harold Copeman

Leedy discusses and reviews Copeman\u27s 1990 book

Small Business Participation in Air Force Procurement: Participation Trends and the Effect of Acquisition Reform Initiatives on Air Force Procurement via Selected Contract Types in Selected Product Categories

Small Businesses (SB) have been of recognized important to the Federal Government for many years. This thesis explores the role of SB contractors in Air Force (AF) procurement and the effects of recent acquisition reform (AR) initiatives on their involvement, including their method of involvement (contract type), product areas in which they participate, and possible new areas of measurement. This thesis answers the research and investigative questions in three ways. First, it explores the correlation of AR initiatives to SB participation as a whole, via selected contract types, and in selected product categories via causal regression models. Next, it identifies trends in AF procurement via selected contract types in selected product categories via descriptive numerical comparison. Finally, it identifies possible product areas for improved SB recruitment. The results of this thesis are as varied as the methodologies employed to answer the research and investigative questions. First, very little correlation was found between acquisition reform initiatives and SB participation. Next, SB participation trends via the selected contract types in the selected product areas varied much greater than overall SB participation. Finally, several product categories were identified as suffering from a decreasing level of SB participation

A new classification of cardio-oncology syndromes

Abstract Increasing evidence suggests a multifaceted relationship exists between cancer and cardiovascular disease (CVD). Here, we introduce a 5-tier classification system to categorize cardio-oncology syndromes (COS) that represent the aspects of the relationship between cancer and CVD. COS Type I is characterized by mechanisms whereby the abrupt onset or progression of cancer can lead to cardiovascular dysfunction. COS Type II includes the mechanisms by which cancer therapies can result in acute or chronic CVD. COS Type III is characterized by the pro-oncogenic environment created by the release of cardiokines and high oxidative stress in patients with cardiovascular dysfunction. COS Type IV is comprised of CVD therapies and diagnostic procedures which have been associated with promoting or unmasking cancer. COS Type V is characterized by factors causing systemic and genetic predisposition to both CVD and cancer. The development of this framework may allow for an increased facilitation of cancer care while optimizing cardiovascular health through focused treatment targeting the COS type

Singing Ancient Greek: A Guide to Musical Reconstruction and Performance

This handbook, by a professional musician rather than a professional classicist, presents the basic facts about Greek pronunciation, rhythm, melody, and tunings and offers musical reconstructions of selected passages of ancient Greek poetry intended for modern performers.About the author: A resident of his native Oregon, Douglas Leedy (b. 1938) is a composer, as well as a conductor specializing in early Western music; he has written extensively on tuning and intonation in musical theory and practice. He studied classical Indian singing with K. V. Narayanaswamy and Pandit Pran Nath; his Greek studies began at the University of California, Berkeley, under Elroy Bundy and Gerson Rabinowitz.About this publication: the Department of Classics is pleased to host this suggestive work by a UC Berkeley alumnus. It has not proved practical to typeset the work, but it has been judged to be a useful addition to the literature on reconstructing Greek musical performance, presenting the unique perspective of a practicing musician and musicologist and thus complementing the efforts of classical scholars. It is therefore offered here as is, scanned from the typescript and manuscript pages

Singing Ancient Greek: A Guide to Musical Reconstruction and Performance

This handbook, by a professional musician rather than a professional classicist, presents the basic facts about Greek pronunciation, rhythm, melody, and tunings and offers musical reconstructions of selected passages of ancient Greek poetry intended for modern performers.About the author: A resident of his native Oregon, Douglas Leedy (b. 1938) is a composer, as well as a conductor specializing in early Western music; he has written extensively on tuning and intonation in musical theory and practice. He studied classical Indian singing with K. V. Narayanaswamy and Pandit Pran Nath; his Greek studies began at the University of California, Berkeley, under Elroy Bundy and Gerson Rabinowitz.About this publication: the Department of Classics is pleased to host this suggestive work by a UC Berkeley alumnus. It has not proved practical to typeset the work, but it has been judged to be a useful addition to the literature on reconstructing Greek musical performance, presenting the unique perspective of a practicing musician and musicologist and thus complementing the efforts of classical scholars. It is therefore offered here as is, scanned from the typescript and manuscript pages

Lack of Association Between Neurohormonal Blockade and Survival in Transthyretin Cardiac Amyloidosis

Background Despite the belief that heart failure therapies are not effective in transthyretin cardiac amyloidosis, data are limited. We tested the association of neurohormonal blockade use with survival. Methods and Results A total of 309 consecutive patients with transthyretin cardiac amyloidosis were identified. Medication inventory was obtained at baseline and subsequent visits. Exposure included a neurohormonal blockade class (β‐blocker [βB], angiotensin‐converting enzyme inhibitor/angiotensin receptor blocker, and mineralocorticoid antagonist) at baseline and subsequent visits. βB was modeled as baseline use, time‐varying use, and in an inverse probability treatment weighted model. Primary outcome was all‐cause mortality analyzed with adjusted Cox proportional hazards models. Continuing compared with stopping βB during follow‐up was tested. Mean age was 73.2 years, 84.1% were men, and 17.2% had atrial fibrillation/flutter at baseline. At the time of study entry, 49.8% were on βBs, 35.0% were on angiotensin‐converting enzyme inhibitors/angiotensin receptor blockers, and 23.9% were on mineralocorticoid antagonists. For the total cohort, there was a trend toward harm in the unadjusted model for baseline βB use, but this was neutral after adjustment. When βB use was analyzed as a time‐varying exposure, there was no association with mortality. βB discontinuation was associated with decreased mortality for the total cohort. Findings were consistent in inverse probability treatment weighted models. For angiotensin‐converting enzyme inhibitor/angiotensin receptor blocker or mineralocorticoid antagonist use, there was no association with mortality after adjustment for the total cohort. Conclusions There was no association of neurohormonal blockade use with survival in transthyretin cardiac amyloidosis. For the total cohort, deprescribing βB may be associated with improved survival. Additional studies are needed to confirm these findings

The association between heart failure and incident cancer in women: an analysis of the Women's Health Initiative

AimsThere is conflicting evidence whether heart failure (HF) is a risk factor for incident cancer. Despite population-based cohorts demonstrating this association, an analysis of the Physician's Health Study found no association in a cohort of mostly healthy males. We investigated the association of HF with incident cancer among a large cohort of post-menopausal women.Methods and resultsA prospective cohort study of 146 817 post-menopausal women age 50 to 79 years enrolled in the Women's Health Initiative from 1993-1998, and followed through 2015. The primary exposure was adjudicated incident HF diagnosis, including preserved and reduced ejection fraction in a sub-cohort. The primary outcome was adjudicated incident total and site-specific cancers. Hazard ratios were calculated using multivariable-adjusted Cox proportional hazard regression models. Over a median follow-up of 8.4 years, 3272 and 17 474 women developed HF and cancer, respectively. HF developed in 235 women prior to cancer. HF was associated with subsequent incident cancer [hazard ratio (HR) 1.28, 95% confidence interval (CI) 1.11-1.48]. Associations were observed for obesity-related cancers (HR 1.24, 95% CI 1.02-1.51), as well as lung and colorectal cancers (HR 1.58, 95% CI 1.09-2.30 and HR 1.52, 95% CI 1.02-2.27, respectively). HF with preserved ejection fraction (HR 1.34, 95% CI 1.06-1.67), but not HF reduced ejection fraction (HR 0.99, 95% CI 0.74-1.34), was associated with total cancer.ConclusionHeart failure was associated with an increase in cancer diagnoses in post-menopausal women. This association was strongest for lung cancer. Further research is needed to appreciate the underlying mechanisms responsible for this association