CMOS transceiver with baud rate clock recovery for optical interconnects

An efficient baud rate clock and data recovery architecture is applied to a double sampling/integrating front-end receiver for optical interconnects. Receiver performance is analyzed and projected for future technologies. This front-end allows use of a 1:5 demux architecture to achieve 5Gb/s in a 0.25 μm CMOS process. A 5:1 multiplexing transmitter is used to drive VCSELs for optical transmission. The transceiver chip consumes 145mW per link at 5Gb/s with a 2.5V supply

Decision Making Framework Using Probabilistic Pareto for Sustainable Packaging Life Cycle Assessment

The Packaging industry is one of the largest industries in the world and is associated with many environmental concerns. To reduce its environmental impacts, designing sustainable packaging has been one of the top priorities in packaging industries. A common tools for evaluating the environmental impact of a package design is the Life Cycle Assessment (LCA) which provides information on environmental impacts for different indicators. However, making decisions based on the LCA results leaves us with major challenges. First, the LCA tools should consider various uncertainties such as measurement and data quality. Second, the LCA may give conflicting results on different environmental impact factors. To address these issues, a ranking based decision making framework is proposed in this paper. Within this framework a Probabilistic Pareto Selection method is introduced to select the Pareto Front with uncertainty first. Then, the Ranking based Rate of Substitution is implemented in the decision making process in order to select the best design options based on the trade-off of each Pareto design. Tow case studies are presented to demonstrate the functionality of this framework

A 12b 50MS/s 2.1mW SAR ADC with redundancy and digital background calibration

A 12-bit 50MS/s SAR ADC implemented in 65nm CMOS technology is presented. The design employs redundancy to relax the DAC settling requirement and to provide sufficient room for errors such that the static nonlinearity caused by capacitor mismatches can be digitally removed. The redundancy is incorporated into the design using a tri-level switching scheme and our modified split-capacitor array to achieve the highest switching efficiency while still preserving the symmetry in error tolerance. A new code-density based digital background calibration algorithm that requires no special calibration signals or additional analog hardware is also developed. The calibration is performed by using the input signal as stimulus and the effectiveness is verified both in simulation and through measured data. The prototype achieves a 67.4dB SNDR at 50MS/s, while dissipating 2.1mW from a 1.2V supply, leading to FoM of 21.9fJ/conv.-step at Nyquist frequency.MIT Masdar Progra

Inhibition of c-Jun NH(2)-terminal kinase or extracellular signal-regulated kinase improves lung injury

BACKGROUND: Although in vitro studies have determined that the activation of mitogen-activated protein (MAP) kinases is crucial to the activation of transcription factors and regulation of the production of proinflammatory mediators, the roles of c-Jun NH(2)-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) in acute lung injury have not been elucidated. METHODS: Saline or lipopolysaccharide (LPS, 6 mg/kg of body weight) was administered intratracheally with a 1-hour pretreatment with SP600125 (a JNK inhibitor; 30 mg/kg, IO), or PD98059 (an MEK/ERK inhibitor; 30 mg/kg, IO). Rats were sacrificed 4 hours after LPS treatment. RESULTS: SP600125 or PD98059 inhibited LPS-induced phosphorylation of JNK and ERK, total protein and LDH activity in BAL fluid, and neutrophil influx into the lungs. In addition, these MAP kinase inhibitors substantially reduced LPS-induced production of inflammatory mediators, such as CINC, MMP-9, and nitric oxide. Inhibition of JNK correlated with suppression of NF-κB activation through downregulation of phosphorylation and degradation of IκB-α, while ERK inhibition only slightly influenced the NF-κB pathway. CONCLUSION: JNK and ERK play pivotal roles in LPS-induced acute lung injury. Therefore, inhibition of JNK or ERK activity has potential as an effective therapeutic strategy in interventions of inflammatory cascade-associated lung injury

The Effects of Feature Optimization on High-Dimensional Essay Data

Current machine learning (ML) based automated essay scoring (AES) systems have employed various and vast numbers of features, which have been proven to be useful, in improving the performance of the AES. However, the high-dimensional feature space is not properly represented, due to the large volume of features extracted from the limited training data. As a result, this problem gives rise to poor performance and increased training time for the system. In this paper, we experiment and analyze the effects of feature optimization, including normalization, discretization, and feature selection techniques for different ML algorithms, while taking into consideration the size of the feature space and the performance of the AES. Accordingly, we show that the appropriate feature optimization techniques can reduce the dimensions of features, thus, contributing to the efficient training and performance improvement of AES

Associations among Organochlorine Pesticides, Methanobacteriales, and Obesity in Korean Women

BACKGROUND: Although Methanobacteriales in the gut has recently been linked to obesity, no study has examined the hypothesis that waist circumference, a marker of visceral obesity, are positively associated with Methanobacteriales in the general population. Since Methanobacteriales increase in a petroleum-contaminated environment to biodegrade petroleum as one way of autopurification, we also hypothesized that high body burden of highly lipophilic petroleum-based chemicals like organochlorine pesticides (OCPs) is associated with higher levels of Methanobacteriales in the gut. METHODOLOGY/PRINCIPAL FINDINGS: Among 83 Korean women who visited a community health service center for a routine health checkup, quantitative real-time PCR (qPCR) based on 16S rDNA was used to quantify Methanobacteriales in feces. Nine OCPs were measured in both serum and feces of 16 subjects. Methanobacteriales were detected in 32.5% (27/83 women). Both BMI and waist circumference among women with Methanobacteriales were significantly higher than in women without Methanobacteriales (P = 0.04 and P = 0.01, respectively). Also, Methanobacteriales levels in feces were positively associated with BMI and waist circumference (r = +0.23 and P = 0.03 for both). Furthermore, there were significant correlations between feces Methanobacteriales levels and serum concentrations of most OCPs, including with cis-nonachlor (r = +0.53, P<0.05), oxychlordane (r = +0.46, P<0.1), and trans-nonachlor (r = +0.43, P<0.1). Despite high correlations of serum and feces concentrations of most OCPs, feces OCP concentrations were not clearly associated with feces Methanobacteriales levels. CONCLUSION/SIGNIFICANCE: In this cross-sectional study, the levels of Methanobacteriales in the human gut were associated with higher body weight and waist circumference. In addition, serum OCP concentrations were positively correlated with levels of Methanobacteriales. There may be a meaningful link among body burden of OCP, Methanobacteriales in the gut, and obesity in the general population