14 research outputs found
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The Production and Repair of Aflatoxin B{sub 1}-induced DNA Damage
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Symposium Overview: Genetic Polymorphisms in DNA Repair and Cancer Risk
A symposium,
Genetic Polymorphisms in DNA Repair and Cancer Risk, was presented at the 40th Annual Meeting of the Society of Toxicology, held in San Francisco, California, in March 2001. A brief report of the symposium was published (Kaiser,
Science 292, 837–838, 2001). Molecular epidemiological studies have shown that polymorphic variants of genes involved in the metabolism and repair of carcinogens can act as
cancer susceptibility genes. These variants of drug metabolic and DNA-repair enzymes either increase the activation of chemical carcinogens or decrease the cells' ability to detoxify/repair mutagenic damages. Although on an individual basis these variant alleles may only slightly change catalytic activity and increase cancer risk, their polymorphic frequency in the human population may contribute to a high proportion of cancer cases. Studies conducted over the past few years have identified variant alleles for a number of DNA-repair genes, some of which have been shown to change DNA-repair capacity. Identifying these genotypic alterations in DNA-repair enzymes and their association with cancer may help to elucidate the mechanisms of cancer etiology and to predict both disease risk and response to cancer therapy, since most antineoplastic treatments mediate their effects through DNA damage
VCP, a Weak ATPase Involved in Multiple Cellular Events, Interacts Physically with BRCA1 in the Nucleus of Living Cells
Temperature and the Formation of Radiation-induced Chromosome Aberrations. I. The Effect of Irradiation Temperature
Intracistronic transcription termination in polysialyltransferase gene (siaD ) affects phase variation in Neisseria meningitidis
Transcription-coupled Repair of Oxidative DNA Damage in Human Cells: Mechanisms and Consequences
Estudo eletrocardiográfico de equinos de salto sadios
Avaliou-se o eletrocardiograma de 100 equinos sadios praticantes de hipismo clássico modalidade salto, com idades entre 4 e 19 anos, sendo 61 machos e 39 fêmeas, com média de 516,3 kg. Observou-se frequência cardÃaca média de 40,20 ±13,33 bpm, sendo o ritmo cardÃaco mais freqüente o sinusal (56%). As alterações de ritmo cardÃaco estiveram presentes em 38% dos animais estudados, sendo a mais presente o marcapasso migratório (22%), seguido de bloqueio atrioventricular de 2º grau (4%), bloqueio atrioventricular de 1º grau (3%), contração ventricular prematura (2%), contração atrial prematura (1%). Não se observou correlação entre as variáveis estudadas (freqüência cardÃaca, ritmo e arritmias) e a capacidade atlética, a idade e o sexo. O escore cardÃaco após analise estatÃstica não diferiu entre os grupos quanto ao desempenho atlético, a faixa etária e o sexo. O escore cardÃaco, nesta amostra, não se mostrou um parâmetro confiável para se predizer o futuro atlético ou o nÃvel de treinamento do eqüino