1,277 research outputs found
Report of AAPM Therapy Physics Committee Task Group 74: InĂą air output ratio, Sc, for megavoltage photon beams
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134830/1/mp7367.pd
Genome Resources for ClimateâResilient Cowpea, an Essential Crop for Food Security
Cowpea (Vigna unguiculata L. Walp.) is a legume crop that is resilient to hot and droughtâprone climates, and a primary source of protein in subâSaharan Africa and other parts of the developing world. However, genome resources for cowpea have lagged behind most other major crops. Here we describe foundational genome resources and their application to the analysis of germplasm currently in use in West African breeding programs. Resources developed from the African cultivar IT97Kâ499â35 include a wholeâgenome shotgun (WGS) assembly, a bacterial artificial chromosome (BAC) physical map, and assembled sequences from 4355 BACs. These resources and WGS sequences of an additional 36 diverse cowpea accessions supported the development of a genotyping assay for 51 128 SNPs, which was then applied to five biâparental RIL populations to produce a consensus genetic map containing 37 372 SNPs. This genetic map enabled the anchoring of 100 Mb of WGS and 420 Mb of BAC sequences, an exploration of genetic diversity along each linkage group, and clarification of macrosynteny between cowpea and common bean. The SNP assay enabled a diversity analysis of materials from West African breeding programs. Two major subpopulations exist within those materials, one of which has significant parentage from South and East Africa and more diversity. There are genomic regions of high differentiation between subpopulations, one of which coincides with a cluster of nodulin genes. The new resources and knowledge help to define goals and accelerate the breeding of improved varieties to address food security issues related to limitedâinput smallâholder farming and climate stress
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MEAD - A Platform for Multidocument Multilingual Text Summarization
This paper describes the functionality of MEAD, a comprehensive, public domain, open source, multidocument multilingual summarization environment that has been thus far downloaded by more than 500 organizations. MEAD has been used in a variety of summarization applications ranging from summarization for mobile devices to Web page summarization within a search engine and to novelty detection
Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprinting
Eliciting antibodies to surface-exposed viral glycoproteins can generate protective responses that control and prevent future infections. Targeting conserved sites may reduce the likelihood of viral escape and limit the spread of related viruses with pandemic potential. Here we leverage rational immunogen design to focus humoral responses on conserved epitopes. Using glycan engineering and epitope scaffolding in boosting immunogens, we focus murine serum antibody responses to conserved receptor binding motif (RBM) and receptor binding domain (RBD) epitopes following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike imprinting. Although all engineered immunogens elicit a robust SARS-CoV-2-neutralizing serum response, RBM-focusing immunogens exhibit increased potency against related sarbecoviruses, SARS-CoV, WIV1-CoV, RaTG13-CoV, and SHC014-CoV; structural characterization of representative antibodies defines a conserved epitope. RBM-focused sera confer protection against SARS-CoV-2 challenge. Thus, RBM focusing is a promising strategy to elicit breadth across emerging sarbecoviruses without compromising SARS-CoV-2 protection. These engineering strategies are adaptable to other viral glycoproteins for targeting conserved epitopes
A Deep Learning Pipeline for Assessing Ventricular Volumes from a Cardiac Magnetic Resonance Image Registry of Single Ventricle Patients
Purpose: To develop an end-to-end deep learning (DL) pipeline for automated ventricular segmentation of cardiac MRI data from a multicenter registry of patients with Fontan circulation (FORCE). /
Materials and Methods: This retrospective study used 250 cardiac MRI examinations (November 2007âDecember 2022) from 13 institutions for training, validation, and testing. The pipeline contained three DL models: a classifier to identify short-axis cine stacks and two UNet 3+ models for image cropping and segmentation. The automated segmentations were evaluated on the test set (n = 50) using the Dice score. Volumetric and functional metrics derived from DL and ground truth manual segmentations were compared using Bland-Altman and intraclass correlation analysis. The pipeline was further qualitatively evaluated on 475 unseen examinations. /
Results: There were acceptable limits of agreement (LOA) and minimal biases between the ground truth and DL end-diastolic volume (EDV) (Bias: -0.6 mL/m2, LOA: -20.6â19.5 mL/m2), and end-systolic volume (ESV) (Bias: - 1.1 mL/m2, LOA: -18.1â15.9 mL/m2), with high intraclass correlation coefficients (ICC > 0.97) and Dice scores (EDV, 0.91 and ESV, 0.86). There was moderate agreement for ventricular mass (Bias: -1.9 g/m2, LOA: -17.3â13.5 g/m2) and a ICC (0.94). There was also acceptable agreement for stroke volume (Bias:0.6 mL/m2, LOA: -17.2â18.3 mL/m2) and ejection fraction (Bias:0.6%, LOA: -12.2%â13.4%), with high ICCs (> 0.81). The pipeline achieved satisfactory segmentation in 68% of the 475 unseen examinations, while 26% needed minor adjustments, 5% needed major adjustments, and in 0.4%, the cropping model failed. /
Conclusion: The DL pipeline can provide fast standardized segmentation for patients with single ventricle physiology across multiple centers. This pipeline can be applied to all cardiac MRI examinations in the FORCE registry
The Angular Correlation Function of Galaxies from Early SDSS Data
The Sloan Digital Sky Survey is one of the first multicolor photometric and
spectroscopic surveys designed to measure the statistical properties of
galaxies within the local Universe. In this Letter we present some of the
initial results on the angular 2-point correlation function measured from the
early SDSS galaxy data. The form of the correlation function, over the
magnitude interval 18<r*<22, is shown to be consistent with results from
existing wide-field, photographic-based surveys and narrower CCD galaxy
surveys. On scales between 1 arcminute and 1 degree the correlation function is
well described by a power-law with an exponent of ~ -0.7. The amplitude of the
correlation function, within this angular interval, decreases with fainter
magnitudes in good agreement with analyses from existing galaxy surveys. There
is a characteristic break in the correlation function on scales of
approximately 1-2 degrees. On small scales, < 1', the SDSS correlation function
does not appear to be consistent with the power-law form fitted to the 1'<
theta <0.5 deg data. With a data set that is less than 2% of the full SDSS
survey area, we have obtained high precision measurements of the power-law
angular correlation function on angular scales 1' < theta < 1 deg, which are
robust to systematic uncertainties. Because of the limited area and the highly
correlated nature of the error covariance matrix, these initial results do not
yet provide a definitive characterization of departures from the power-law form
at smaller and larger angles. In the near future, however, the area of the SDSS
imaging survey will be sufficient to allow detailed analysis of the small and
large scale regimes, measurements of higher-order correlations, and studies of
angular clustering as a function of redshift and galaxy type
Multi-Messenger Gravitational Wave Searches with Pulsar Timing Arrays: Application to 3C66B Using the NANOGrav 11-year Data Set
When galaxies merge, the supermassive black holes in their centers may form
binaries and, during the process of merger, emit low-frequency gravitational
radiation in the process. In this paper we consider the galaxy 3C66B, which was
used as the target of the first multi-messenger search for gravitational waves.
Due to the observed periodicities present in the photometric and astrometric
data of the source of the source, it has been theorized to contain a
supermassive black hole binary. Its apparent 1.05-year orbital period would
place the gravitational wave emission directly in the pulsar timing band. Since
the first pulsar timing array study of 3C66B, revised models of the source have
been published, and timing array sensitivities and techniques have improved
dramatically. With these advances, we further constrain the chirp mass of the
potential supermassive black hole binary in 3C66B to less than using data from the NANOGrav 11-year data set. This
upper limit provides a factor of 1.6 improvement over previous limits, and a
factor of 4.3 over the first search done. Nevertheless, the most recent orbital
model for the source is still consistent with our limit from pulsar timing
array data. In addition, we are able to quantify the improvement made by the
inclusion of source properties gleaned from electromagnetic data to `blind'
pulsar timing array searches. With these methods, it is apparent that it is not
necessary to obtain exact a priori knowledge of the period of a binary to gain
meaningful astrophysical inferences.Comment: 14 pages, 6 figures. Accepted by Ap
The NANOGrav 11-Year Data Set: Arecibo Observatory Polarimetry And Pulse Microcomponents
We present the polarization pulse profiles for 28 pulsars observed with the
Arecibo Observatory by the North American Nanohertz Observatory for
Gravitational Waves (NANOGrav) timing project at 2.1 GHz, 1.4 GHz, and 430 MHz.
These profiles represent some of the most sensitive polarimetric millisecond
pulsar profiles to date, revealing the existence of microcomponents (that is,
pulse components with peak intensities much lower than the total pulse peak
intensity). Although microcomponents have been detected in some pulsars
previously, we present microcomponents for PSRs B1937+21, J1713+0747, and
J2234+0944 for the first time. These microcomponents can have an impact on
pulsar timing, geometry, and flux density determination. We present rotation
measures for all 28 pulsars, determined independently at different observation
frequencies and epochs, and find the Galactic magnetic fields derived from
these rotation measures to be consistent with current models. These
polarization profiles were made using measurement equation template matching,
which allows us to generate the polarimetric response of the Arecibo
Observatory on an epoch-by-epoch basis. We use this method to describe its time
variability, and find that the polarimetric responses of the Arecibo
Observatory's 1.4 and 2.1 GHz receivers vary significantly with time.Comment: 41 pages, 20 figure
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