Anthropization processes and protection of the environment: an assessment of land cover changes in Sardinia, Italy

Protection of the environment is implemented through preventive and mitigating measures aimed at hindering anthropization processes. These measures may possibly entail the establishment of natural protected areas and sites where conservation measures are stated under the provisions of the “Habitats” Directive (no. 92/43/EEC) and Directive no. 2009/147/EC (the so-called “Birds” Directive, which modifies Directive no. 79/409/EEC). A straightforward way of assessing widespread anthropization processes consists in analyzing land cover changes related artificialization processes concerning natural areas. In this study, we assess land cover changes by using the simplified land cover taxonomy of the Land and Ecosystem Account classes and by analyzing transition processes; in addition, we propose a comparative appraisal of land cover changes occurring in areas characterized by different protection regimes, as follows: areas protected under the provisions of national or regional acts or regulations, sites belonging to the Natura 2000 network, that is protected under the Habitats or Birds Directives, and unprotected areas. We analyze anthropization processes that take place in Sardinia, an Italian insular region characterized by the presence of several national and regional protected areas and by a significant system of Natura 2000 sites, and assess land cover changes over a twelve-year period (2000-2012). The outcomes of our study put in evidence important lessons related to the definition and implementation of planning policies aiming at preventing anthropization processes in Sardinia. Moreover, the assessment methodology we implement in our study can be exported to other European regions in order to set up planning processes which fit the local features of land cover changes

Green Infrastructure and Regional Planning: An Operational Framework

Identifying and planning green infrastructures at the regional scale can be considered an intentional way of spreading the positive impacts of environmental conservation policies across spatial contexts much more complex and larger than protected areas. In this volume, a methodological approach is defined and experimentally implemented into the Sardinian region (Italy), in order to identify both a regional green infrastructure, and a network of ecological corridors, conceived as edges connecting the regional protected areas. This approach supports spatial decision-making processes aimed at addressing environmental hazards connected to landslides and floods, as well as at establishing effective spatial planning rules

Strengthening a regional green infrastructure through improved multifunctionality and connectedness: Policy suggestions from Sardinia, Italy

A wide body of research in the latest years has studied either green infrastructures as providers of multiple ecosystem services, especially at the urban level, or ecological corridors and the issue of connectivity between landscape patches in the face of growing fragmentation. However, not many studies have analyzed how the two concepts can be combined to ground evidence-based policy and planning recommendations. In this study, a methodological approach for such combination is proposed: after mapping a regional green infrastructure building upon the assessment of multiple ecosystem services, and a network of ecological corridors through resistance to movement of species, the two spatial layouts are combined so as to analyze correlations between the potential provision of ecosystem services and the resistance to movement. The methodology is applied in the case of the island of Sardinia, whose self-containment makes it possible to discard potential effects from surrounding areas, hence facilitating the implementation of the model. The outcomes of the regression model point out to three ecosystem services as the most important factors that should be targeted by appropriate spatial policies, if connectivity is to be increased: regulation of micro and local climate, forestry productivity, and cultural identity and heritage values

United-and-Close: An interactive visual platform for assessing urban segregation within the 15-minutes paradigm

The ‘15-minute city’ paradigm is an urban model based on the concept of ‘hyper-proximity’: citizens should be able to access fundamental services and facilities (such as schools, shops, parks, doctors, and markets) within 15-20 minutes on foot, by bicycle or by public transport. Compliance with the ‘15-minute city’ paradigm is supposed to reduce pollution and social inequalities. It is supposed to bring the psychological fragility of the citizen back to the center of the urban redevelopment debate. Although the concept has gained great attention and interest from policymakers and urban designers, we still lack tools that can help to validate, on a data-driven basis, the assumption that hyper-proximity is eventually correlated with lower urban segregation, which is one of the driving forces that lead to social inequalities. We aim to define a data-driven methodology to analyze the urban areas where services should be accessible within 15 minutes; network analysis is exploited to estimate services proximity as well as the connectivity of different urban areas with each other, in order to gather signals of the general resilience or exposure to urban segregation. We also aim to compute a set of city-agnostic metrics that will include user-specified parameters and personalized weights for each Point of Interest’s category. United-and-Close is the resulting Web platform designed to be accessible to citizens, policy and decision-makers, and investors, but also for researchers involved in disciplines such as urban informatics that need support to better assess the 15-minute paradigm and its actual impact on our cities

Valutazione ambientale strategica, piani urbanistici comunali e piani dei parchi. Un quadro operativo per l’integrazione della Strategia regionale per lo sviluppo sostenibile della Sardegna

La concezione della sostenibilità, nel governo del territorio, va oltre la tutela dell’ambiente in quanto, oltre il profilo ambientale, include quelli economici e sociali. Si evidenzia, quindi, la necessità di rendere compatibili le esigenze dello sviluppo economico con quelle della tutela delle risorse naturali, e dell’equità e del progresso sociale. In quest’ottica, la Regione Sardegna ha approvato la Strategia regionale per lo sviluppo sostenibile (SRSvS), quale declinazione della Strategia nazionale, in coerenza con l’Agenda 2030 delle Nazioni Unite. Il volume presenta e discute i risultati di una ricerca sviluppata durante lo svolgimento del Laboratorio di ricerca azione SOSLab1 del Progetto SOSLabs, condotto, presso l’Università di Cagliari, nell’ambito del bando emanato nel 2019 dalla Direzione Generale per lo Sviluppo Sostenibile, per il Danno Ambientale e per i Rapporti con l’Unione Europea dell’allora Ministero dell’Ambiente e della Tutela del territorio e del mare (oggi Ministero dell’Ambiente e della Sicurezza energetica). Gli esiti si basano su un approccio metodologico che integra la SRSvS nella prassi della pianificazione territoriale e urbanistica nel contesto comunale e metropolitano, tramite un modello in cui la costruzione del piano è permeata dalla valutazione. Si assume quale riferimento scientifico e tecnico la valutazione ambientale strategica (VAS), in virtù del suo essere profondamente innervata nel processo di piano, quasi ad identificarsi con il piano stesso, sia nelle fasi preparatorie, che attuative. La metodologia di integrazione della SRSvS nel processo di pianificazione e valutazione è applicata, sperimentalmente, a due piani urbanistici: il Piano urbanistico comunale preliminare del Comune di Cagliari e il Piano del Parco naturale regionale di Tepilora

Food and Alcohol Disturbance in High School Adolescents: Prevalence, Characteristics and Association with Problem Drinking and Eating Disorders

Food and alcohol disturbance (FAD) is characterized by the association of alcohol use with compensatory behaviors such as restricting calories, physical activity and purging. Despite not being part of the current nosography, research has grown in the past 10 years, mostly on college students’ samples. In this study, we aim to describe the prevalence, characteristics and association of FAD with problem drinking (PD) and eating disorder risk (EDR) in a sample of Italian high school students. Participants were 900 high school students (53.6% males; mean age = 16.22) that were administered standardized questionnaires. Students who screened positive for PD, EDR and both were, respectively, 17.3%, 5.9% and 1.3%. Approximately one out four students reported FAD behaviors, mostly to control weight and by restricting calories, with higher prevalence and severity among those who screened positive for PD. Purging behaviors were rare overall (15.5%), but significantly more frequent in participants who screened positive for both PD and EDR (41.7%). FAD was more strongly associated with alcohol use severity than with ED symptom severity across all subgroups. FAD behaviors appear to be common in the Italian high school population and more strongly associated with PD. Future studies should investigate FAD’s impact on adolescents’ functioning and possible early interventions

Metabolic Alteration in Plasma and Biopsies From Patients With IBD

BACKGROUND: Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the gastrointestinal tract, with periods of latency alternating with phases of exacerbation, and include 2 forms: Crohn disease (CD) and ulcerative colitis (UC). Although the etiology of IBD is still unclear, the identification and understanding of pathophysiological mechanisms underlying IBD could reveal newly targeted intestinal alterations and determine therapeutic approaches.METHODS: In this study, by using gas chromatography-mass spectrometry, we characterized plasma and biopsies from the metabolomics profiles of patients with IBD compared with those of a control group.RESULTS: The results showed a different metabolomics profile between patients with CD (n = 50) and patients with UC (n = 82) compared with the control group (n = 51). Multivariate statistical analysis of the identified metabolites in CD and UC showed changes in energetic metabolism, and lactic acid and ornithine in particular were altered in both plasma and colon biopsies. Moreover, metabolic changes were evidenced between the normal ileum and colon tissues. These differences disappeared when we compared the inflamed ileum and colon tissues, suggesting a common metabolism.CONCLUSIONS: This study showed how the metabolomics profile could be a potential tool to identify intestinal alterations associated with IBD and may have application in precision medicine and for better defining the pathogenesis of the disease

Clinical global impression-severity score as a reliable measure for routine evaluation of remission in schizophrenia and schizoaffective disorders

Aims: This study aimed to compare the performance of Positive and Negative Syndrome Scale (PANSS) symptom severity criteria established by the Remission in Schizophrenia Working Group (RSWG) with criteria based on Clinical Global Impression (CGI) severity score. The 6-month duration criterion was not taken into consideration. Methods: A convenience sample of 112 chronic psychotic outpatients was examined. Symptomatic remission was evaluated according to RSWG severity criterion and to a severity criterion indicated by the overall score obtained at CGI-Schizophrenia (CGI-SCH) rating scale (≤3) (CGI-S). Results: Clinical remission rates of 50% and 49.1%, respectively, were given by RSWG and CGI-S, with a significant level of agreement between the two criteria in identifying remitted and non-remitted cases. Mean scores at CGI-SCH and PANSS scales were significantly higher among remitters, independent of the remission criteria adopted. Measures of cognitive functioning were largely independent of clinical remission evaluated according to both RSWG and CGI-S. When applying RSWG and CGI-S criteria, the rates of overall good functioning yielded by Personal and Social Performance scale (PSP) were 32.1% and 32.7%, respectively, while the mean scores at PSP scale differed significantly between remitted and non-remitted patients, independent of criteria adopted. The proportion of patients judged to be in a state of well-being on Social Well-Being Under Neuroleptics-Short Version scale (SWN-K) were, respectively, 66.1% and 74.5% among remitters according to RSWG and CGI-S; the mean scores at the SWN scale were significantly higher only among remitters according to CGI-S criteria. Conclusions: CGI severity criteria may represent a valid and user-friendly alternative for use in identifying patients in remission, particularly in routine clinical practic

Safety at high altitude: the importance of emotional dysregulation on pilots’ risk attitudes during flight

IntroductionAviation psychology is very interested in understanding how personological and psychological variables influence flight performances. Indeed, risk attitudes have been considered as a risk factor for aviation accidents. In this context, emotions and coping style are key variables which could influence concentration by affecting cognition and attention. In addition, the specific training backgrounds seemed to be associated with differences in in-flight accident rates. The aim of the present study was to investigate the association between age, sex, flight experience, emotional dysregulation, coping styles, flight licenses, and pilots’ risk attitudes.MethodsEighty pilots completed an online survey composed of ad hoc questionnaire for sociodemographic and work-related information’s and self-report questionnaires that assessed emotional dysregulation, coping styles, and risk attitudes.ResultsResults showed that older age and emotional dysregulation were associated with higher risk attitudes in pilots. Moreover, emotional dysregulation seemed to promote worse self-confidence. Ultralight pilots appeared to be more risk-oriented and less self-confident than civil pilots, while more flight experience appeared to favorite greater self-confidence.DiscussionIn conclusion, the study suggests the importance of promoting interventions based on sharing pilots’ difficulties and emotions and promoting safe attitudes with special attention to ultralight pilots, age, and sex differences

A top-down proteomic approach reveals a salivary protein profile able to classify Parkinson's disease with respect to Alzheimer's disease patients and to healthy controls

Parkinson's disease (PD) is a complex neurodegenerative disease with motor and non-motor symptoms. Diagnosis is complicated by lack of reliable biomarkers. To individuate peptides and/or proteins with diagnostic potential for early diagnosis, severity and discrimination from similar pathologies, the salivary proteome in 36 PD patients was investigated in comparison with 36 healthy controls (HC) and 35 Alzheimer's disease (AD) patients. A top-down platform based on HPLC-ESI-IT-MS allowed characterizing and quantifying intact peptides, small proteins and their PTMs (overall 51). The three groups showed significantly different protein profiles, PD showed the highest levels of cystatin SA and antileukoproteinase and the lowest of cystatin SN and some statherin proteoforms. HC exhibited the lowest abundance of thymosin & beta;4, short S100A9, cystatin A, and dimeric cystatin B. AD patients showed the highest abundance of & alpha;-defensins and short oxidized S100A9. Moreover, different proteoforms of the same protein, as S-cysteinylated and S-glutathionylated cystatin B, showed opposite trends in the two pathological groups. Statherin, cystatins SA and SN classified accurately PD from HC and AD subjects. & alpha;-defensins, histatin 1, oxidized S100A9, and P-B fragments were the best classifying factors between PD and AD patients. Interestingly statherin and thymosin & beta;4 correlated with defective olfactory functions in PD patients. All these outcomes highlighted implications of specific proteoforms involved in the innate-immune response and inflammation regulation at oral and systemic level, suggesting a possible panel of molecular and clinical markers suitable to recognize subjects affected by PD