23 research outputs found
Integrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids
International audienceThe worldwide incidence of pulmonary carcinoids is increasing, but little is known about their molecular characteristics. Through machine learning and multi-omics factor analysis, we compare and contrast the genomic profiles of 116 pulmonary carcinoids (including 35 atypical), 75 large-cell neuroendocrine carcinomas (LCNEC), and 66 small-cell lung cancers. Here we report that the integrative analyses on 257 lung neuroendocrine neoplasms stratify atypical carcinoids into two prognostic groups with a 10-year overall survival of 88% and 27%, respectively. We identify therapeutically relevant molecular groups of pulmonary car-cinoids, suggesting DLL3 and the immune system as candidate therapeutic targets; we confirm the value of OTP expression levels for the prognosis and diagnosis of these diseases, and we unveil the group of supra-carcinoids. This group comprises samples with carcinoid-like morphology yet the molecular and clinical features of the deadly LCNEC, further supporting the previously proposed molecular link between the low-and high-grade lung neuroendocrine neoplasms
Hidradénite suppurée et maladies parodontales
REIMS-BU Santé (514542104) / SudocSudocFranceF
Relation maladie parodontale et diabète (données actuelles de la littérature)
REIMS-BU Santé (514542104) / SudocPARIS-BIUM (751062103) / SudocLILLE2-UFR Odontologie (593502202) / SudocSudocFranceF
Anesthésie intraosseuse : apports et intérêts dans la pratique odontologique quotidienne
REIMS-BU Santé (514542104) / SudocSudocFranceF
Les répercussions psychologiques de la chirurgie orthognatique
REIMS-BU Santé (514542104) / SudocSudocFranceF
Préservation de l'os alvéolaire (aspects préprothétiques)
REIMS-BU Santé (514542104) / SudocPARIS-BIUM (751062103) / SudocLILLE2-UFR Odontologie (593502202) / SudocSudocFranceF
La dépendance à l'héroine : conséquences bucco-dentaires et prise en charge au cabinet dentaire
REIMS-BU Santé (514542104) / SudocSudocFranceF
Les petits rats de la dentisterie : illustration de la vie en odontologie universitaire
REIMS-BU Santé (514542104) / SudocSudocFranceF
Etat bucco-dentaire de la population gauloise de Brienne sur Aisne (époque de la Tène II)
REIMS-BU Santé (514542104) / SudocPARIS-BIUM (751062103) / SudocLILLE2-UFR Odontologie (593502202) / SudocSudocFranceF
L'avenir du LASER au cabinet dentaire
REIMS-BU Santé (514542104) / SudocSudocFranceF