Clever classrooms : Summary report of the HEAD project

Based on the results of the HEAD Project (Holistic Evidence and Design), funded by the Engineering and Physical Sciences Research Council, clear evidence has been found that well-designed primary schools boost children’s academic performance in reading, writing and maths. Differences in the physical characteristics of classrooms explain 16% of the variation in learning progress over a year for the 3766 pupils included in the study. Or to make this more tangible, it is estimated that the impact of moving an ‘average’ child from the least effective to the most effective space would be around 1.3 sub-levels, a big impact when pupils typically make 2 sub-levels progress a year. This report summarises and illustrates the design and practice implications for architects and designers

Women's stereotype threat‐based performance motivation and prepotent inhibitory ability

According to the mere effort account of performance, stereotype threat motivates disproval of the negative performance stereotype, which in turn potentiates the overproduction of prepotent responses. In mathematics (maths), prepotent responding facilitates solve type question (e.g., equations) performance, but reduces comparison type question (e.g., estimations) performance. Problematically, the mere effort account indexes performance motivation as task performance. Also, this account posits that performance reduction on non-prepotent tasks derives from the overproduction of prepotent responses, as opposed to failed inhibition of prepotent responses associated with the alternative, namely, the working memory interference perspective. We investigated motivational and prepotent responding as applied to stereotype threat. In Experiment 1, a maths question selection task indexed motivation (independently of performance). Stereotype threat led female test-takers to select more solve than comparison maths questions, in accord with the mere effort account. In Experiment 2, higher inhibitory ability protected overall maths performance following stereotype threat, but it did not protect non-prepotentiated comparison question performance (inconsistent with the working memory interference perspective). The results support the mere effort account

Examining the Decline in the C~IV Content of the Universe over 4.3 ≲ z ≲ 6.3 using the E-XQR-30 Sample

Intervening C iv absorbers are key tracers of metal-enriched gas in galaxy haloes over cosmic time. Previous studies suggest that the C iv cosmic mass density (⁠[Math Processing Error]⁠) decreases slowly over 1.5 [Math Processing Error] 5 before declining rapidly at z ≳ 5, but the cause of this downturn is poorly understood. We characterize the [Math Processing Error] evolution over 4.3 ≲ z ≲ 6.3 using 260 absorbers found in 42 XSHOOTER spectra of z ∼ 6 quasars, of which 30 come from the ESO Large Program XQR-30. The large sample enables us to robustly constrain the rate and timing of the downturn. We find that [Math Processing Error] decreases by a factor of 4.8 ± 2.0 over the ∼300 Myr interval between z ∼ 4.7 and ∼5.8. The slope of the column density (log N) distribution function does not change, suggesting that C iv absorption is suppressed approximately uniformly across 13.2 ≤ log N/cm−2 < 15.0. Assuming that the carbon content of galaxy haloes evolves as the integral of the cosmic star formation rate density (with some delay due to stellar lifetimes and outflow travel times), we show that chemical evolution alone could plausibly explain the fast decline in [Math Processing Error] over 4.3 ≲ z ≲ 6.3. However, the C iv/C ii ratio decreases at the highest redshifts, so the accelerated decline in [Math Processing Error] at z ≳ 5 may be more naturally explained by rapid changes in the gas ionization state driven by evolution of the UV background towards the end of hydrogen reionization

Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling

Although concern remains about the athero-thrombotic risk posed by cyclo-oxygenase (COX)-2-selective inhibitors, recent data implicates rofecoxib, while celecoxib appears equivalent to NSAIDs naproxen and ibuprofen. We investigated the hypothesis that celecoxib activates AMP kinase (AMPK) signalling to enhance vascular endothelial protection. In human arterial and venous endothelial cells (EC), and in contrast to ibuprofen and naproxen, celecoxib induced the protective protein heme oxygenase-1 (HO-1). Celecoxib derivative 2,5-dimethyl-celecoxib (DMC) which lacks COX-2 inhibition also upregulated HO-1, implicating a COX-2-independent mechanism. Celecoxib activated AMPKα(Thr172) and CREB-1(Ser133) phosphorylation leading to Nrf2 nuclear translocation. Importantly, these responses were not reproduced by ibuprofen or naproxen, while AMPKα silencing abrogated celecoxib-mediated CREB and Nrf2 activation. Moreover, celecoxib induced H-ferritin via the same pathway, and increased HO-1 and H-ferritin in the aortic endothelium of mice fed celecoxib (1000 ppm) or control chow. Functionally, celecoxib inhibited TNF-α-induced NF-κB p65(Ser536) phosphorylation by activating AMPK. This attenuated VCAM-1 upregulation via induction of HO-1, a response reproduced by DMC but not ibuprofen or naproxen. Similarly, celecoxib prevented IL-1β-mediated induction of IL-6. Celecoxib enhances vascular protection via AMPK-CREB-Nrf2 signalling, a mechanism which may mitigate cardiovascular risk in patients prescribed celecoxib. Understanding NSAID heterogeneity and COX-2-independent signalling will ultimately lead to safer anti-inflammatory drugs

Clostridium difficile ribotypes in Austria: a multicenter, hospital-based survey

A prospective, noninterventional survey was conducted among Clostridium difficile positive patients identified in the time period of July until October 2012 in 18 hospitals distributed across all nine Austrian provinces. Participating hospitals were asked to send stool samples or isolates from ten successive patients with C.difficile infection to the National Clostridium difficile Reference Laboratory at the Austrian Agency for Health and Food Safety for PCR-ribotyping and in vitro susceptibility testing. A total of 171 eligible patients were identified, including 73 patients with toxin-positive stool specimens and 98 patients from which C. difficile isolates were provided. Of the 159 patients with known age, 127 (74.3 %) were 65 years or older, the median age was 76 years (range: 9–97 years), and the male to female ratio 2.2. Among these patients, 73 % had health care-associated and 20 % community-acquired C. difficile infection (indeterminable 7 %). The all-cause, 30-day mortality was 8.8 % (15/171). Stool samples yielded 46 different PCR-ribotypes, of which ribotypes 027 (20 %), 014 (15.8 %), 053 (10.5 %), 078 (5.3 %), and 002 (4.7 %) were the five most prevalent. Ribotype 027 was found only in the provinces Vienna, Burgenland, and Lower Austria. Severe outcome of C. difficile infection was found to be associated with ribotype 053 (prevalence ratio: 3.04; 95 % CI: 1.24, 7.44), not with the so-called hypervirulent ribotypes 027 and 078. All 027 and 053 isolates exhibited in vitro resistance against moxifloxacin. Fluoroquinolone use in the health care setting must be considered as a factor favoring the spread of these fluoroquinolone resistant C. difficile clones

Amyand's Hernia – Case Report and Review of the Literature

Amyand's hernia is an extremely rare condition in which the appendix is positioned in the inguinal hernia sac. Acute appendicitis is much less common in this situation and few reports are found in the literature. We report a case of acute appendicitis with the tip of the appendix incarcerated outside the external ring of the right groin. A mobilized cecum and ascending colon were noticed during surgery. We conducted a review of the literature, emphasizing possible causes and suggesting a predisposing factor for the condition