Prevalence of polycystic ovary syndrome in a population of women of reproductive age using Rotterdam 2003 criteria (literature review)

Polycystic ovary syndrome (PCOS) is considered a common endocrine disorder among women of reproductive age, and the associated health risks persist throughout life. At the same time, there is a wide range of variations in the incidence of the syndrome (4–21 %), which in turn is explained by the influence of the study population characteristics, including ethnicity and race, as well as the applied diagnostic criteria. The aim of the study. To systematize the available data on the prevalence of polycystic ovary syndrome using the Rotterdam 2003 criteria in a population of women of reproductive age. Materials and methods. The search for information was carried out using Internet resources (PubMed, EMBASE, Google Scholar, eLibrary). Literature sources for  the  period 1990–2023 were analyzed. As a result, the article presents current data on the prevalence of PCOS using the Rotterdam 2003 definitions, the features of the PCOS incidence in hospital and non-selective (medically unbiased) populations, as well as in various ethnic groups. The review also discusses current guidelines for conducting studies on the PCOS prevalence. Conclusion. The latest guidelines on the diagnosis and management of patients with PCOS, published in 2018, propose to consider the provisions adopted in Rotterdam as the basis for the diagnosis of the syndrome; at the same time, the need to take into account racial and age characteristics is noted

BANKING SECTOR OF THE SAMARA REGION: HISTORY OF FORMATION, CURRENT STATE, DEVELOPMENT PROSPECTS

The article is devoted to the study of the formation of the banking sector in the Samara region. The stages of development of the banking organizations of the region are presented, special attention is paid to the performance indicators of banking organizations at the present time. The structure of financial resources of credit institutions is studied, a review of performance indicators of banking organizations, such as the value of net assets, the amount of financial result, the level of return on equity. Prospects for the development of the banking sector of the Samara region are considered, they are more connected with the specifics of the activities of regional banks

BANKING SECTOR OF THE SAMARA REGION: HISTORY OF FORMATION, CURRENT STATE, DEVELOPMENT PROSPECTS

The article is devoted to the study of the formation of the banking sector in the Samara region. The stages of development of the banking organizations of the region are presented, special attention is paid to the performance indicators of banking organizations at the present time. The structure of financial resources of credit institutions is studied, a review of performance indicators of banking organizations, such as the value of net assets, the amount of financial result, the level of return on equity. Prospects for the development of the banking sector of the Samara region are considered, they are more connected with the specifics of the activities of regional banks

Semantic features of the phraseological units with the component light within the artistic discourse

Conduct lexical and semantic analysis on the concept light in the artistic discourse of postmodern fictio

FREQUENCY AND METHODS OF CORRECTION OF MAGNESIUM DEFICIENCY IN YOUNG WOMEN OF REPRODUCTIVE AGE AT TAKING COMBINED ORAL CONTRACEPTIVE PILLS

Magnesium is one of the important elements, necessary for the most of biochemical reactions, including those in nerve tissue. Magnesium insufficiency takes a leading position in the structure of elemental status pathology. 20-63 % of females of 18-45 years have borderline or moderate magnesium deficiency. Earlier conducted studies showed decreased level of magnesium in blood serum of women using combined oral contraceptive pills (COCP). We examined 137 young females of reproductive age (average age -19,1 ± 1,1 years) and defined the level of magnesium in blood serum and 24-hour urine at the background of taking COCP. Depending on the level of magnesium in blood serum all women were divided into 2 groups. Females who planned to use COCP and had initially normal level of magnesium in blood serum (n = 88) were randomized to form groups of observation and prophylaxis (with the use of magnesium preparations). All women with reduced level of magnesium (n = 49) together with hormonal contraceptive were prescribed magnesium preparation in combination with pyridoxine. The women with preventive use of magnesium-containing preparation had no significant reduction of magnesium level either in blood or in urine. And the women with reduced Mg level who were taking COCP and received magnesium-containing preparation in combination with pyridoxine had increased level of magnesium in blood serum and 24-hour urine. Thus, prescription of magnesium preparations in combination with pyridoxine to young women of reproductive age using combined oral contraceptive pills has been proved reasonable for reducing the risk of magnesium deficiency

Финансовая статистическая отчетность медицинских организаций: существующие недостатки и направления оптимизации

The article discusses some of the shortcomings in financial statistical reports provided by medical organizations in the healthcare sector, namely: duplication and intersection of indicators in different reporting forms, the inconvenient data format for their presentation and analysis, the lack of correlation between indicators of statistical reporting and internal management accounting. To solve these problems, the authors propose the ways of improving the financial reporting by medical organizations: among them, optimizing the system of indicators, abandoning the statistical reporting forms in favor of creating databases (possibly, with outsourcing assistance), as well as creating the uniform rules for maintaining internal management accounting in medical organizations.В статье рассматриваются некоторые существующие недостатки финансовой статистической отчетности, предоставляемой медицинскими организациями в сфере здравоохранения, а именно: дублирование и пересечение показателей в разных отчетных формах, неудобный формат данных для их предоставления и анализа, отсутствие взаимосвязи между показателями статистической отчетности и внутриорганизационным управленческим учетом. Для решения указанных проблем авторами статьи предлагаются такие направления совершенствования финансовой отчетности медицинских организаций как оптимизация системы показателей, отказ от форм статистической отчетности в пользу формирования баз данных, в том числе с применением аутсорсинга, а также создание единых правил ведения внутреннего управленческого учета в медицинских организациях

The research of abnormal toxicity and local irritant effect in the Draize test of the drug furacilin, concentrate for the preparation of a solution for local and externaluse

The research of abnormal toxicity and locally irritating effect of the drug Furacilin, concentrate for the preparation of a solution for local and external use in comparison with the drug Furacilin, tablets for the preparation of the solution, was carried ou

Endometrial morphology in women of reproductive age with PCOS

Background. Polycystic ovary syndrome is the most common endocrine disease in women, affecting various aspects of health. The results of several studies indicate an increased prevalence of hyperplasia or endometrial cancer in women with PCOS, but there are no clinical recommendations on the need for assessing the endometrial condition in PCOS and approaches to predictions. Aim: to determine the frequency and structure of endometrial pathology among reproductive-aged patients with PCOS. Materials and methods. In a cross-sectional survey, we examined 1200 women who are subject to annual preventive examination. The research period was May - December 2017. The diagnosis of PCOS was made according to the consensus criteria adopted in May 2003 in Rotterdam. Participants signed informed consent for the survey. Results. We found 102 women with a verified diagnosis of PCOS. 56 of them completed their participation in the study; the median age was 32.19 ± 5.67 years. All patients underwent a biopsy of the endometrium with immunohistochemical examination. Features of the structure of the endometrium: a normal endometrial characteristic in 24 women (42.9 %), chronic endometritis -18 specimens (58.1 %), abnormal hypoplastic endometrium - 6 (19.4 %), simple endometrial hyperplasia -1 (3.2 %) adenocarcinoma -1 (3.2 %), proliferative endometrium with disorders - 7(22.6 %). Conclusions. In the examined women with PCOS there was a high incidence of histologically confirmed endometrial pathology, in the structure of which chronic endometritis predominates. The foregoing necessitates new research and development of clinical protocols for the timely detection of endometrial pathology in PCOS

Age-related determinants of the metabolic syndrome in women of reproductive age of the main ethnic groups of the Baikal Region

The aim of the study. To determine the age limit of the initial manifestations of the metabolic syndrome in women of reproductive age of the Caucasian and Asian ethnic groups. Materials and methods. The study included women of reproductive age of the Russian and Buryat ethnic groups (n = 1231). We carried out general clinical examination, studied glycemia levels and lipid metabolism indicators. The analysis of the components of the metabolic syndrome was performed taking into account age characteristics and ethnicity. Threshold values for the age of metabolic disorders manifestation were determined. Results. It was found that the main components of the metabolic syndrome in women of reproductive age of the Russian and Buryat ethnic groups were a decrease in  high-density lipoprotein (HDL), an increase in waist circumference, and an increase in blood pressure. The age-related determinants of the metabolic syndrome in the  population of women of reproductive age in the Baikal region were determined. It was shown that the age-related determinants of the metabolic syndrome in Caucasian and Asian women do not differ significantly and amount to 33.5 years (95% confidence interval (95% CI): 32.5; 38.5) and 36.5 years (95% CI: 27.5; 52.5), respectively. A universal critical age value was determined as 34.5 years (95% CI: 32.5; 38.5), which is associated with a significant increase in the prevalence of the metabolic syndrome in accordance with the ATP  III criteria. The ranking of metabolic syndrome criteria in the studied groups revealed the following order of their occurrence: the decrease in HDL index prevailed, followed by the increase in waist circumference, blood pressure, glucose and triglycerides; no dependence on the ethnicity was found. Conclusion. When assessing the age-related determinants of the metabolic syndrome in the mixed Caucasoid-Asian group, it is advisable to use universal approaches, taking into account the cut-off point of age, which is 34.5 years. The determination of age criteria for the correct classification of patients with respect to the manifestations of the metabolic syndrome is necessary to analyze the contribution of the age factor to the implementation of various metabolic syndrome predictors, to  develop prognostic models, and to  use effective age-determined markers of metabolic disorders

CHARACTERISTICS OF PITUITARY-OPVARIAN-ADRENAL AXIS IN ADOLESCENT GIRLS WITH HYPERPROLACTINEMIA OF VARIOUS GENESIS

The article presents the results of examination of 97 adolescent girls (mean age 14,96 ± 0,26 years) with hyperprolactinemia (PRL levels above 700 IU/ml): 30 adolescent girls with pituitary microprolactinoma (mean age 14,7 ± 3.2 years) and 67 adolescent girls with functional hyperprolactinemia (mean age 14,6 ± 3,4 years). The control group included 35 healthy adolescent girls (mean age 15,8 ± 0,89 years). Hyperprolactinemia (tumor and non-neoplastic) in puberty leads to disorders of sexual development and ovarian-menstrual cycle, followed by neurological symptoms. Elevated concentrations of testosterone, cortisol, DHEA, 17-OH-progesterone and LH/FSH ratio were shown in adolescents with hyperprolactinemia compared to the control group. Macroprolactinemia was estimated in 16,4—20 % of girls with hyperprolactinemia