A Systematic View of Information-Based Optimal Subdata Selection: Algorithm Development, Performance Evaluation, and Application in Financial Data

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Deep Learning Analysis of Urban Growth Boundaries: An Evaluation of Effectiveness in Mitigating Urban Sprawl in China

Although urban growth boundaries (UGBs) have been employed as a planning tool in certain Western cities for decades, they have recently been adopted in Chinese cities to address urban sprawl. However, the effectiveness of UGBs in different types of Chinese cities, particularly those on flatlands versus mountains, has not been studied. This study aimed to compare the efficacy of UGBs in a city on flatlands (Chengdu, China) and a mountainous city (Chongqing, China). We used a deep learning architecture (U-Net) to project urban expansions in 2035 with the presence/absence of UGBs and landscape metrics to evaluate UGBs' effectiveness in mitigating urban sprawl. We found significant differences in historical urban expansion between Chengdu and Chongqing from 1992 to 2019. Chengdu experienced spillover sprawl under a monocentric-dominated urban form, while Chongqing witnessed leapfrog and piece-mall sprawl under a polycentric form. Despite the differences in UGBs designation, the simulations demonstrated that UGBs could mitigate urban sprawl in both cities in 2035, with Chengdu exhibiting more pronounced effectiveness. Notably, UGBs were more effective in controlling spillover sprawl in Chengdu, whereas they could effectively reduce leapfrog sprawl in Chongqing. However, UGBs were constrained by strict top-down land quotas, limiting their potential. These findings suggested that implementing UGBs should adopt differentiated goals and strategies for different types of cities

Detection of SNPs in the BMP6 Gene and Their Association with Carcass and Bone Traits in Chicken

<div><p>ABSTRACT BMP6, a member of the subfamilies of the morphogenetic proteins (BMPs), plays a crucial role in osteogenic and chondrocyte differentiation in vitro and stimulates chondrogenesis, making chondrocytes differen-tiate on their terminal stage. The objective of this study is to explore the relationship between polymorphism of BMP6 gene and slaughter traits in chicken respectively. We screened the exonic and intronic regions of BMP6 gene by DNA pool construction and amplified DNA fragment by PCR, and finally, we got nine SNPs. Association analysis revealed that BMP6 had no significant association among all slaughter traits in Yellow bantam chicken. However, BMP6 had a significant difference with femur weight, tibia weight, femur length (p<0.05), and was extremely significant with tibia length (p<0.01) in Avian chicken. Moreover, femur perimeter also had significant correlation with BMP6 in Avian chicken. These results provide useful information for further investigation on the function of chicken BMP6 gene.</p></div

Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks

Metformin is the front-line treatment for type 2 diabetes worldwide. It acts via effects on glucose and lipid metabolism in metabolic tissues, leading to enhanced insulin sensitivity. Despite significant effort, the molecular basis for metformin response remains poorly understood, with a limited number of specific biochemical pathways studied to date. To broaden our understanding of hepatic metformin response, we combine phospho-protein enrichment in tissue from genetically engineered mice with a quantitative proteomics platform to enable the discovery and quantification of basophilic kinase substrates in vivo. We define proteins whose binding to 14-3-3 are acutely regulated by metformin treatment and/or loss of the serine/threonine kinase, LKB1. Inducible binding of 250 proteins following metformin treatment is observed, 44% of which proteins bind in a manner requiring LKB1. Beyond AMPK, metformin activates protein kinase D and MAPKAPK2 in an LKB1-independent manner, revealing additional kinases that may mediate aspects of metformin response. Deeper analysis uncovered substrates of AMPK in endocytosis and calcium homeostasis