The multimedia technologies and the new realities for knowledge networking and valorisation of scientific cultural heritage. The role of the Italian University Museums network

The framework program about multimedia technologies for the networking and the valorization of scientific cultural heritage in the Italian University Museums among thirteen Italian Universities (Bari, Cagliari, Chieti-Pescara, Ferrara, Florence, Modena and Reggio Emilia, Parma, Perugia, Rome “La Sapienza”, Salento, Naple II, Siena, Tuscia), with the coordination of the University of Modena, has been recently approved and financed by the Italian Ministry of Education, University and Research. It aims at activating a network that by multimedia technologies wish contribute to knowledge and valorization of cultural heritage through the collaboration of UMAC University Museums and Collections International Committee of ICOM. The final target will be a bilingual web portal realized, on purpose for the project, in an innovative perspective considering the peculiar features of the different University Museums collections, the experience of each, their interdisciplinary characterization and the possible uses in a contemporary historical, social and cultural context. The first step is to monitor the cultural heritage of the thirteen University Museums, in order to complete the already existing databases and align them to catalogue standards released by the Central Institute for Cataloguing and Documentation of the Italian Ministry of the Culture within the General Informative System for Cataloguing SIGECWeb

Targeting Drp1 and mitochondrial fission for therapeutic immune modulation

Mitochondria are dynamic organelles whose processes of fusion and fission are tightly regulated by specialized proteins, known as mitochondria-shaping proteins. Among them, Drp1 is the main pro-fission protein and its activity is tightly regulated to ensure a strict control over mitochondria shape according to the cell needs. In the recent years, mitochondrial dynamics emerged as a new player in the regulation of fundamental processes during T cell life. Indeed, the morphology of mitochondria directly regulates T cell differentiation, this by affecting the engagment of alternative metabolic routes upon activation. Further, Drp1-dependent mitochondrial fission sustains both T cell clonal expansion and T cell migration and invasivness. By this review, we aim at discussing the most recent findings about the roles played by the Drp1-dependent mitochondrial fission in T cells, and at highlighting how its pharmacological modulation could open the way to future therapeutic approaches to modulate T cell response

ICONA: Inter Cluster ONOS Network Application

Several Network Operating Systems (NOS) have been proposed in the last few years for Software Defined Networks; however, a few of them are currently offering the resiliency, scalability and high availability required for production environments. Open Networking Operating System (ONOS) is an open source NOS, designed to be reliable and to scale up to thousands of managed devices. It supports multiple concurrent instances (a cluster of controllers) with distributed data stores. A tight requirement of ONOS is that all instances must be close enough to have negligible communication delays, which means they are typically installed within a single datacenter or a LAN network. However in certain wide area network scenarios, this constraint may limit the speed of responsiveness of the controller toward network events like failures or congested links, an important requirement from the point of view of a Service Provider. This paper presents ICONA, a tool developed on top of ONOS and designed in order to extend ONOS capability in network scenarios where there are stringent requirements in term of control plane responsiveness. In particular the paper describes the architecture behind ICONA and provides some initial evaluation obtained on a preliminary version of the tool.Comment: Paper submitted to a conferenc

Gamers’ Sensations of Spatial, Social, And Co-Presence While Playing Online Video Games

There is an increasing number of video gamers who are playing games online. Previous research has demonstrated that off line gamers experience sensations of presence “the illusion of non-mediation” (Lombard & Ditton, 1997). The current study, explores through focus groups, the type of presence online gamers report experiencing. The results demonstrate that online gamers report having sensations that can be classified into all three main presence types: spatial (physical), social, and co-presence

Gamers’ Sensations of Spatial, Social, And Co-Presence While Playing Online Video Games

There is an increasing number of video gamers who are playing games online. Previous research has demonstrated that off line gamers experience sensations of presence “the illusion of non-mediation” (Lombard & Ditton, 1997). The current study, explores through focus groups, the type of presence online gamers report experiencing. The results demonstrate that online gamers report having sensations that can be classified into all three main presence types: spatial (physical), social, and co-presence

A numerical approach for the modelling of forming limits in hot incremental forming of AZ31 magnesium alloy

Magnesium alloys, because of their good specific material strength, can be considered attractive by different industry fields, as the aerospace and the automotive one. However, their use is limited by the poor formability at room temperature. In this research, a numerical approach is proposed in order to determine an analytical expression of material formability in hot incremental forming processes. The numerical model was developed using the commercial software ABAQUS/Explicit. The Johnson-Cook material model was used, and the model was validated through experimental measurements carried out using the ARAMIS system. Different geometries were considered with temperature varying in a range of 25–400 °C and wall angle in a range of 35–60°. An analytical expression of the fracture forming limit, as a function of temperature, was established and finally tested with a different geometry in order to assess the validity

Sphingosine-1-Phosphate in the Tumor Microenvironment: A Signaling Hub Regulating Cancer Hallmarks

As a key hub of malignant properties, the cancer microenvironment plays a crucial role intimately connected to tumor properties. Accumulating evidence supports that the lysophospholipid sphingosine-1-phosphate acts as a key signal in the cancer extracellular milieu. In this review, we have a particular focus on glioblastoma, representative of a highly aggressive and deleterious neoplasm in humans. First, we highlight recent advances and emerging concepts for how tumor cells and different recruited normal cells contribute to the sphingosine-1-phosphate enrichment in the cancer microenvironment. Then, we describe and discuss how sphingosine-1-phosphate signaling contributes to favor cancer hallmarks including enhancement of proliferation, stemness, invasion, death resistance, angiogenesis, immune evasion and, possibly, aberrant metabolism. We also discuss the potential of how sphingosine-1-phosphate control mechanisms are coordinated across distinct cancer microenvironments. Further progress in understanding the role of S1P signaling in cancer will depend crucially on increasing knowledge of its participation in the tumor microenvironment