Astroparticle and neutrino oscillation research with KM3NeT

Two next generation underwater neutrino telescopes are under construction in the Mediterranean sea by the KM3NeT Collaboration. The first, ORCA, optimised for atmospheric neutrinos detection will be capable to determine the neutrino mass hierarchy with > 3σ after three years of operation, i.e. as early as 2023. The second, ARCA, is optimised for high energy neutrino astronomy. Its location allows for surveying most of the Galactic Plane, including the Galactic Centre and the most promising source candidates. The neutrino diffuse emission flux measured by the IceCube Collaboration can be observed with 5σ in less than one year

Endoscopic Drainage of the Pancreatic Pseudocyst through the Stomach or Duodenal Wall

In the article we have presented early outcome and long-term outcome of the usage of various methods of endoscopic drainage of the pancreatic pseudocyst through the stomach or duodenal wall in 56 patient

Bile a-Amylase and Lipase - Possible Predictors of Acute Pancreatitis in Case of Bile Duct Stone Impacted at the Major Duodenal Papilla

The results of diagnostics and treatment of 102 patients with bile duct stone impacted at the major duodenal papilla were subject to analysis. The obtained results demonstrate that the level of bile α-amylase and lipase may serve as a predictor of acute biliary pancreatitis progressio

Endoscopic biliary stenting for post-cholecystectomy bile leaks

This paper deals analyzes the treatment experience of 15 patients with bile leakage after laparoscopic cholecystectomy. All patients have undergone endoscopic transpapillary interventions in the bile ducts, including a retrograde cholangiography, papillotomy, biliary stenting, either individually or in combination with traditional surger

Diagnostics and Treatment of Acute Biliary Pancreatitis

The authors have suggested a new diagnostic algorithm to be applied in case of impacted bile duct stone of major duodenal papilla, based on prognosis of acute pancreatitis according to results of analysis of biochemical bile marker

The Use of Diamond - Like Carbon Coated Surgical Polypropylene Meshes for Incisional Hernia Repair

Application of diamond-like carbon (DLC) coated surgical polypropylene meshes compared to similar prostheses without coating at surgical incisional hernia repair enables to decrease intensity of local inflammatory reaction in the operation are

Renal cell carcinoma drug and cell therapy: today and tomorrow

The paper also looks at clinically applicable targeted immune drugs and the principle of their effect on tumorous cells. Besides, modern clinical studies of cell drugs have been considere

Gene polimorphism and endometrium hyperplastic processes

The objective of the study was the bioinformatical study of the involvement of candidate genes in the formation of endometrium hyperplastic processe

Epistatic interactions in formation of hysteromyoma

The article highlights the bioinformatics analysis data of eight polymorphous loci among 569 patients with hysteromyoma and 981 women from the control grou

Investigation of chemical constituents of Eranthis longistipitata (Ranunculaceae): coumarins and furochromones

Aqueous‐ethanol extracts (70%) from the leaves of Eranthis longistipitata Regel. (Ranunculaceae Juss.)—collected from natural populations of Kyrgyzstan—were studied by liquid chromatography with high‐resolution mass spectrometry (LC‐HRMS). There was no variation of the metabolic profiles among plants that were collected from different populations. More than 160 compounds were found in the leaves, of which 72 were identified to the class level and 58 to the individual‐ compound level. The class of flavonoids proved to be the most widely represented (19 compounds), including six aglycones [quercetin, kaempferol, aromadendrin, 6‐methoxytaxifolin, phloretin, and (+)‐catechin] and mono‐ and diglycosides (the other 13 compounds). In the analyzed samples of E. longistipitata, 14 fatty acid–related compounds were identified, but coumarins and furochromones that were found in E. longistipitata were the most interesting result; furochromones khelloside, khellin, visnagin, and cimifugin were found in E. longistipitata for the first time. Coumarins 5,7‐dihydroxy‐4‐methylcoumarin, scoparone, fraxetin, and luvangetin and furochromones methoxsalen, 5‐O‐methylvisammioside, and visamminol‐3′‐O‐glucoside were detected for the first time in the genus Eranthis Salisb. For all the above compounds, the structural formulas are given. Furthermore, detailed information (with structural formulas) is provided on the diversity of chromones and furochromones in other representatives of Eranthis. The presence of chromones in plants of the genus Eranthis confirms its closeness to the genus Actaea L. because chromones are synthesized by normal physiological processes only in these members of the Ranunculaceae family