Визуализация индивидуальных данных студента путем применения современных интернет-сервисов

This article gives the analyze of Internet-services, that provide the opportunity to monitor student's achievements and professional development. The aim of this analyze is to choose the one which will be the most appropriate when we evaluate and compare students abilities.В данной статье проводится анализ интернет-сервисов, позволяющих осуществлять мониторинг достижений и профессионального роста студентов, с целью использования выбранного сервиса при оценке компетенций учащихся

Controlled Transformation of Electrical, Magnetic and Optical Material Properties by Ion Beams

Key circumstance of radical progress for technology of XXI century is the development of a technique which provides controllable producing three-dimensional patterns incorporating regions of nanometer sizes and required physical and chemical properties. Our paper for the first time proposes the method of purposeful direct transformation of the most important substance physical properties, such as electrical, magnetic, optical and others by controllable modification of solid state atomic constitution. The basis of the new technology is discovered by us effect of selective atom removing out of thin di- and polyatomic films by beams of accelerated particles. Potentials of that technique have been investigated and confirmed by our numerous experiments. It has been shown, particularly, that selective atom removing allows to transform in a controllable way insulators into metals, non-magnetics into magnetics, to change radically optical features and some other properties of materials. The opportunity to remove selectively atoms of a certain sort out of solid state compounds is, as such, of great interest in creating technology associated primarily with needs of nanoelectronics as well as many other "nano-problems" of XXI century.Comment: 22 pages, PDF, 9 figure

Совершенствование методик определения примесей в антимикробных лекарственных средствах хроматографическими методами на примере анализа ципрофлоксацина

The need to reduce analysis time when controlling impurities in medicinal products remains an urgent challenge. The aim of the study was to use the example of ciprofloxacin in order to select chromatographic conditions that will significantly accelerate and simplify determination of impurities in medicinal products. Methods: the study was performed using the Chromolith® Performance RP-18e 100×4.6 mm and Acquity UPLC BEH C18 1.7 μm, 100×2.1 mm columns and the Agilent 1290 Infinity chromatography system with a diode array detector. Results: the authors of the study worked out gradient elution modes for determination of ciprofloxacin impurities that involved 15 min run time for fast high-performance liquid chromatography and 12 min run time for ultra-performance liquid chromatography. The identification of impurities was performed based on relative retention times of impurity peaks and their comparison with the reference standard chromatogram. Conclusions: the study demonstrated the possibility of replacing the thin-layer chromatography method used for determination of fluoroquinolonic acid (ciprofloxacin impurity A) with high-performance liquid chromatography. The proposed test conditions allow for identification of ciprofloxacin impurities specified in well-established pharmacopoeias and manufacturers’ product specification files. The obtained data may be used for further development of rapid methods of ciprofloxacin impurities determination in medicinal products. Необходимость сокращения времени анализа при мониторинге содержания примесей в лекарственных средствах является актуальной проблемой. Цель работы: выбор условий хроматографирования, позволяющих значительно ускорить и упростить определение примесей в лекарственных средствах на примере анализа ципрофлоксацина.Методы: для достижения поставленной цели были использованы хроматографические колонки Chromolith® Performance RP-18e 100×4,6 мм и Acquity UPLC BEH C18 1,7 мкм 100×2,1 мм. Исследования проводились на хроматографе «Agilent 1290 Infinity» с диодно-матричным детектором.Результаты: Разработаны режимы градиентного элюирования примесей ципрофлоксацина со временем хроматографирования в течение 15 минут для варианта быстрой высокоэффективной жидкостной хроматографии и 12 минут для варианта ультра высокоэффективной жидкостной хроматографии. Идентификация примесей проведена с использованием относительных времен удерживания их пиков и при сравнении с эталонной хроматограммой.Выводы: Показана возможность замены метода тонкослойной хроматографии для определения фторхинолоновой кислоты (примеси А ципрофлоксацина) методом высокоэффективной жидкостной хроматографии. Предложенные условия анализа позволяют идентифицировать примеси ципрофлоксацина, нормируемые ведущими фармакопеями и нормативными документами. На основе полученных данных возможна дальнейшая разработка экспрессных методик определения примесей ципрофлоксацина в лекарственных средствах

Improvement of Tests for the Control of Impurities in Antimicrobial Medicinal Products by Chromatographic Methods: Ciprofloxacin Case Study

The need to reduce analysis time when controlling impurities in medicinal products remains an urgent challenge. The aim of the study was to use the example of ciprofloxacin in order to select chromatographic conditions that will significantly accelerate and simplify determination of impurities in medicinal products. Methods: the study was performed using the Chromolith® Performance RP-18e 100×4.6 mm and Acquity UPLC BEH C18 1.7 μm, 100×2.1 mm columns and the Agilent 1290 Infinity chromatography system with a diode array detector. Results: the authors of the study worked out gradient elution modes for determination of ciprofloxacin impurities that involved 15 min run time for fast high-performance liquid chromatography and 12 min run time for ultra-performance liquid chromatography. The identification of impurities was performed based on relative retention times of impurity peaks and their comparison with the reference standard chromatogram. Conclusions: the study demonstrated the possibility of replacing the thin-layer chromatography method used for determination of fluoroquinolonic acid (ciprofloxacin impurity A) with high-performance liquid chromatography. The proposed test conditions allow for identification of ciprofloxacin impurities specified in well-established pharmacopoeias and manufacturers’ product specification files. The obtained data may be used for further development of rapid methods of ciprofloxacin impurities determination in medicinal products

The phytosanitary state of the soil and its effect on the CFD-photosynthetic power of cereals

В 2015 году было начато систематическое исследование фитосанитарного состояния опытных площадей в Германии как одна из составных частей международной программы Tandem 12/21 (2012–2021). До сегодняшнего дня на наличие фитопатогенных бактерий и грибов проанализированы и классифицированы 105 из 170 площадей. Предварительная оценка результатов показывает, что доля фитопатогенных бактерий и грибов охватывает диапазон от 0 до 95 %. CFD-измерения показывают, что на 9-11 календарной неделе активность процесса фотосинтеза озимых зерновых на опытных полях с возрастанием доли фитопатогенов снижается почти на 15 %.As part of the international program Tandem 12/21 (2012–2021), the systematic screening of the phytosanitary state of the German trial areas was started in 2015. To date, 105 of the 170 trial sites have been screened and classified for the presence of phytopathogenic bacteria and fungi. An initial evaluation shows that the proportion of phytopathogenic bacteria and fungi covers a range of 0 to 95 %. CFD measurements show that in the 9–11 calendar week, the photosynthetic power of winter crops on these trial areas decreases by almost 15 % as the proportion of phytopathogenic increases