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Increasing thermal plant flexibility in a high renewables power system
Thermal generation is a vital component of mature and reliable electricity markets. As the share of renewable electricity in such markets grows, so too do the challenges associated with its variability. Proposed solutions to these challenges typically focus on alternatives to primary generation, such as energy storage, demand side management, or increased interconnection. Less attention is given to the demands placed on conventional thermal generation or its potential for increased flexibility. However, for the foreseeable future, conventional plants will have to operate alongside new renewables and have an essential role in accommodating increasing supply-side variability.
This paper explores the role that conventional generation has to play in managing variability through the sub-system case study of Northern Ireland, identifying the significance of specific plant characteristics for reliable system operation. Particular attention is given to the challenges of wind ramping and the need to avoid excessive wind curtailment. Potential for conflict is identified with the role for conventional plant in addressing these two challenges. Market specific strategies for using the existing fleet of generation to reduce the impact of renewable resource variability are proposed, and wider lessons from the approach taken are identified
Role of Age in Mitochondrial Susceptibility to 1,3-Dinitrobenzene-Induced Neurotoxicity.
The prevalence of neurodegenerative disease is projected to increase in proportion to the doubling of older Americans over the coming decades. While age is the principle epidemiologic factor, it is likely that the development of these complex neuropathological entities is multifactorial and reflects the accumulation of chemical, physical and/or biological insults to the CNS. The Superfund chemical, 1,3-Dinitrobenzene (DNB), is an industrial intermediate in the production of dyes, plastics, and explosives. DNB selectively targets astrocytes in brainstem nuclei innervated by the 8th cranial nerve. The toxicity of DNB has been previously linked to dysfunction in astrocyte mitochondria. This study focuses on the susceptibility of key mitochondrial proteins to selective and specific oxidation following exposure to DNB in vitro and in vivo. Using an immortalized cortical astrocyte culture, passage number provided a useful surrogate for age in vitro. In a co-culture system containing immortalized astrocytes and primary neurons, low passage immortalized astrocytes are able to protect neurons in DNB exposure (whereas high passage immortalized astrocytes are not); additionally, low passage immortalized astrocytes are better able to survive DNB exposure in co-culture than high passage immortalized astrocytes. Additionally, in vivo data shows that proteins in older mitochondria are more susceptible to oxidation by DNB than the ones from young organelles, and mitochondria-related proteins are more highly expressed in young control animals than in older animals (both control and DNB-exposed). This data suggests that aging increases mitochondrial susceptibility to DNB-induced neurotoxicity. Using a high throughput proteomic approach with subsequent pathway analysis, it was determined that cation transmembrane transporter, nucleoside-triphosphatase, pyrophosphatase, and hydrolase activity pathways are selectively vulnerable to oxidation in older mitochondria. These results provide compelling evidence that environmental chemicals such as DNB may aid in the acceleration of injury to specific brain regions by inducing oxidation of sensitive mitochondrial proteins.PhDToxicologyUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/108896/1/lauramau_1.pd
Measuring the flatness of focal plane for very large mosaic CCD camera
Large mosaic multiCCD camera is the key instrument for modern digital sky
survey. DECam is an extremely red sensitive 520 Megapixel camera designed for
the incoming Dark Energy Survey (DES). It is consist of sixty two 4k2k
and twelve 2k x 2k 250-micron thick fully-depleted CCDs, with a focal plane of
44 cm in diameter and a field of view of 2.2 square degree. It will be attached
to the Blanco 4-meter telescope at CTIO. The DES will cover 5000 square-degrees
of the southern galactic cap in 5 color bands (g, r, i, z, Y) in 5 years
starting from 2011.
To achieve the science goal of constraining the Dark Energy evolution,
stringent requirements are laid down for the design of DECam. Among them, the
flatness of the focal plane needs to be controlled within a 60-micron envelope
in order to achieve the specified PSF variation limit. It is very challenging
to measure the flatness of the focal plane to such precision when it is placed
in a high vacuum dewar at 173 K. We developed two image based techniques to
measure the flatness of the focal plane. By imaging a regular grid of dots on
the focal plane, the CCD offset along the optical axis is converted to the
variation the grid spacings at different positions on the focal plane. After
extracting the patterns and comparing the change in spacings, we can measure
the flatness to high precision. In method 1, the regular dots are kept in high
sub micron precision and cover the whole focal plane. In method 2, no high
precision for the grid is required. Instead, we use a precise XY stage moves
the pattern across the whole focal plane and comparing the variations of the
spacing when it is imaged by different CCDs. Simulation and real measurements
show that the two methods work very well for our purpose, and are in good
agreement with the direct optical measurements.Comment: Presented at SPIE Conference,Ground-based and Airborne
Instrumentation for Astronomy III, San Diego, 201
Use of Flow Cytometric Analysis to Examine the Uptake of Apoptotic Bodies by Healthy Hepatocytes
Discovery of A Very Bright, Strongly-Lensed z=2 Galaxy in the SDSS DR5
We report on the discovery of a very bright z = 2.00 star-forming galaxy that
is strongly lensed by a foreground z=0.422 luminous red galaxy (LRG). This
system was found in a systematic search for bright arcs lensed by LRGs and
brightest cluster galaxies in the Sloan Digital Sky Survey Data Release 5
sample. Follow-up observations on the Subaru 8.2m telescope on Mauna Kea and
the Astrophysical Research Consortium 3.5m telescope at Apache Point
Observatory confirmed the lensing nature of this system. A simple lens model
for the system, assuming a singular isothermal ellipsoid mass distribution,
yields an Einstein radius of 3.82 +/- 0.03 arcsec or 14.8 +/- 0.1 kpc/h at the
lens redshift. The total projected mass enclosed within the Einstein radius is
2.10 +/- 0.03 x 10^12 M_sun/h, and the magnification factor for the source
galaxy is 27 +/- 1. Combining the lens model with our gVriz photometry, we find
an (unlensed) star formation rate for the source galaxy of 32 M_sun/h / yr,
adopting a fiducial constant star formation rate model with an age of 100 Myr
and E(B-V) = 0.25. With an apparent magnitude of r = 19.9, this system is among
the very brightest lensed z >= 2 galaxies, and provides an excellent
opportunity to pursue detailed studies of the physical properties of an
individual high-redshift star-forming galaxy.Comment: 31 pages, 12 figures, 4 tables, submitted to Ap
Chronic alcohol exposure alters circulating insulin and ghrelin levels: role of ghrelin in hepatic steatosis
Fatty liver is the earliest response of the liver to excessive ethanol consumption. Central in the development of alcoholic steatosis is increased mobilization of nonesterified free fatty acids (NEFAs) to the liver from the adipose tissue. In this study, we hypothesized that ethanol-induced increase in ghrelin by impairing insulin secretion, could be responsible for the altered lipid metabolism observed in adipose and liver tissue. Male Wistar rats were fed for 5–8 wk with control or ethanol Lieber-DeCarli diet, followed by biochemical analyses in serum and liver tissues. In addition, in vitro studies were conducted on pancreatic islets isolated from experimental rats. We found that ethanol increased serum ghrelin and decreased serum insulin levels in both fed and fasting conditions. These results were corroborated by our observations of a significant accumulation of insulin in pancreatic islets of ethanol-fed rats, indicating that its secretion was impaired. Furthermore, ethanol-induced reduction in circulating insulin was associated with lower adipose weight and increased NEFA levels observed in these rats. Additionally, we found that increased concentration of serum ghrelin was due to increased synthesis and maturation in the stomach of the ethanol-fed rats. We also report that in addition to its effect on the pancreas, ghrelin can also directly act on hepatocytes via the ghrelin receptors and promote fat accumulation. In conclusion, alcohol-induced elevation of circulating ghrelin levels impairs insulin secretion. Consequently, reduced circulating insulin levels likely contribute to increased free fatty acid mobilization from adipose tissue to liver, thereby contributing to hepatic steatosis
Chronic alcohol exposure alters circulating insulin and ghrelin levels: role of ghrelin in hepatic steatosis
Fatty liver is the earliest response of the liver to excessive ethanol consumption. Central in the development of alcoholic steatosis is increased mobilization of nonesterified free fatty acids (NEFAs) to the liver from the adipose tissue. In this study, we hypothesized that ethanol-induced increase in ghrelin by impairing insulin secretion, could be responsible for the altered lipid metabolism observed in adipose and liver tissue. Male Wistar rats were fed for 5–8 wk with control or ethanol Lieber-DeCarli diet, followed by biochemical analyses in serum and liver tissues. In addition, in vitro studies were conducted on pancreatic islets isolated from experimental rats. We found that ethanol increased serum ghrelin and decreased serum insulin levels in both fed and fasting conditions. These results were corroborated by our observations of a significant accumulation of insulin in pancreatic islets of ethanol-fed rats, indicating that its secretion was impaired. Furthermore, ethanol-induced reduction in circulating insulin was associated with lower adipose weight and increased NEFA levels observed in these rats. Additionally, we found that increased concentration of serum ghrelin was due to increased synthesis and maturation in the stomach of the ethanol-fed rats. We also report that in addition to its effect on the pancreas, ghrelin can also directly act on hepatocytes via the ghrelin receptors and promote fat accumulation. In conclusion, alcohol-induced elevation of circulating ghrelin levels impairs insulin secretion. Consequently, reduced circulating insulin levels likely contribute to increased free fatty acid mobilization from adipose tissue to liver, thereby contributing to hepatic steatosis
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