6 research outputs found
Consideration Of Quality Criteria When Awarding Bus Traffic Contracts
Institute of Transport and Logistics Studies. Faculty of Economics and Business. The University of Sydne
Kvalitetsprogram Arkitektur Nya Stambanor
Nya Stambanors mÄl för arkitektur, stationer och landskap Àr högt stÀllda, samtidigt som vÄr rÄdighet och vÄrt faktiska ansvar Àr begrÀnsande faktorer. Det Àr en utmaning som krÀver samordning inom Trafikverket och med externa aktörer. Att hitta balansen mellan arkitektoniska ambitioner och ekonomiska förutsÀttningar Àr en annan utmaning. MÄlsÀttningen med kvalitetsprogrammet Àr att omhÀnderta de högt stÀllda mÄlen för en lÄngsiktigt ekonomisk hÄllbar anlÀggning dÀr arkitekturen tillför ett mervÀrde och ger kvalitativa lösningar.   Kvalitetsprogram Arkitektur Nya Stambanor Àr ett strategiskt dokument som beskriver inriktningen för arkitekturarbetet inom Nya Stambanor. Nya Stambanor har en lÄng utvecklingstid för de olika programmen och innan systemet kan vara fÀrdigstÀllt i sin helhet. UtgÄngspunkten Àr dÀrför att varje program behöver fÄ vara ett resultat av sin tid och sin kontext sÄ lÀnge arkitekturarbetet tar avstamp ur Kvalitetsprogram Arkitektur
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.
Funder: Kjell och MĂ€rta Beijers StiftelseAlthough physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention