Immune function in mania

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/27250/1/0000258.pd

Electroconvulsive Therapy Increases Plasma Levels of Interleukin-6 a

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74956/1/j.1749-6632.1990.tb40529.x.pd

Fever and leukocytosis: Physical manifestations of bipolar affective disorder?

1. 1. Fever and leukocytosis are occasionally observed in patients with psychiatric disorders. A thorough medical evaluation does not always reveal the origin of these abnormalities.2. 2. We report the case histories of three patients with bipolar affective disorder and an abnormal DST who had fever and leukocytosis during the acute phase of their illness. No organic etiology could be found.3. 3. All three patients responded to ECT with resolution of the depression, the fever, and the leukocytosis, and normalization of the DST.4. 4. We propose that fever and leukocytosis may be rare physical manifestations of bipolar affective disorder, particularly in patients with abnormal DST.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/27598/1/0000642.pd

Suppression of Tumor Necrosis Factor Production by Alcohol in Lipopolysaccharide-Stimulated Culture

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66388/1/j.1530-0277.1994.tb00917.x.pd

Natural killer cell activity in adolescents with major depression,

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29440/1/0000522.pd

Natural killer cell activity in depressive illness: preliminary report

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/27710/1/0000096.pd

Impaired lymphocyte function in depressive illness

Mood states and immunity may be related. To investigate the immune status of patients with primary depressive illness, we compared lymphocytic responses to three different mitogens in 26 drug-free depressed patients and 20 normal controls of comparable age and sex. We observed a generalized and marked decrease in the lymphocyte mitogenic activity among the depressive group. This defect in lymphocyte function may be indicative of an impairment in cell-mediated immunity in patients with primary depressive illness.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/25160/1/0000596.pd

Dexamethasone suppression test and selection of antidepressant medications

Endogenous depressives with abnormal dexamethasone suppression tests (DSTs) respond better to somatic antidepressant treatments than those with normal DSTs. Whether the DST also aids in the selection of specific antidepressants has not been determined. A pilot report suggested that patients with abnormal DSTs might be noradrenaline-deficient and respond preferentially to imipramine or desipramine, whereas those with normal DSTs might be serotonin-deficient and respond best to amitriptyline or clomipramine. Attempting to replicate this observation, we studied 26 patients diagnosed with Research Diagnostic Criteria as major depressive disorder, endogenous subtype, and with DSM-III as having melancholia. All were drug-free during baseline evaluation. All had abnormal DST results, with post-dexamethasone plasma cortisol levels exceeding 5 [mu]g/dl. We treated subjects with either imipramine or amitriptyline and compared clinical response with weekly Hamilton Depression Rating Scales, completed by raters blind to both DST results and the research question. Therapeutic plasma levels were documented. We found no significant differences in treatment response between the subgroups. Twenty of the 26 subjects did well. The imipramine-treated group failed to have either earlier response or better final outcome. These data fail to replicate suggestions that DST results assist in the selection of either imipramine or amitriptyline.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/24183/1/0000442.pd

Positive and negative symptoms in schizophrenia and the dexamethasone suppression test

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/28016/1/0000452.pd

Changes in Mood States and Biomarkers During Peginterferon and Ribavirin Treatment of Chronic Hepatitis C

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74953/1/j.1572-0241.2008.02106.x.pd