387 research outputs found
Venous Thromboembolism as a Preventable Patient Injury: Experience of the Danish Patient Insurance Association (1996 - 2010)
Jagten pÄ den ultimative lÊringsressource
I MONA, 2014(3), var der en spĂŠndende artikel om udviklingen og evalueringen af lĂŠringsspillet Jagten/Kampen1 om rĂ„stofferne som en organiserende ramme om elevernes mĂžde med en udstilling pĂ„ Ăkolariet i Vejle
Successful talent development environments in female Scandinavian Handball: Constellations of communities of practice and its implications for role modeling and interactions between talents, senior players and coaches
Talent development is a sociocultural affair. The social learning perspective is rarely used for the study of talent development in sport, although it is broadly known in the domain of education. This article examines the way in which communities of practice are connected within two exceptional successful talent development environments, what characterises talentsâ movements across communities of practice within the club, and what characterises the interactions between talents, senior players and coaches. Drawing on Wengerâs notion of communities of practice, constellations of interconnected practices and boundary encounters, it identifies how the two environments were characterised by (1) a well-functioning constellation of several CoPs, (2) opportunities for talents to participate and engage in various CoPs (3), individually adjusted feedback from coach to player combined with communication between the players with different positions in the CoPs and not only coach instructions, and (4) senior elite playersâ engaging behaviours in regard to newcomers in the boundary encounters and thereby legitimate peripheral participation opportunities for talented players. (5) The coaches were the key to coordinate the interconnected practices and social interactions between the âyouth CoPâ and âsenior elite CoPâ.Talent development is a sociocultural affair. The social learning perspective is rarely used for the study of talent development in sport, although it is broadly known in the domain of education. This article examines the way in which communities of practice are connected within two exceptional successful talent development environments, what characterises talentsâ movements across communities of practice within the club, and what characterises the interactions between talents, senior players and coaches. Drawing on Wengerâs notion of communities of practice, constellations of interconnected practices and boundary encounters, it identifies how the two environments were characterised by (1) a well-functioning constellation of several CoPs, (2) opportunities for talents to participate and engage in various CoPs (3), individually adjusted feedback from coach to player combined with communication between the players with different positions in the CoPs and not only coach instructions, and (4) senior elite playersâ engaging behaviours in regard to newcomers in the boundary encounters and thereby legitimate peripheral participation opportunities for talented players. (5) The coaches were the key to coordinate the interconnected practices and social interactions between the âyouth CoPâ and âsenior elite CoPâ
Hvad blev der lige af perspektivet?
Kommentar til JĂžrgen LĂžye Christiansen: âNaturfaglige kompetencer i grundskolen â hvilke bĂžr der fokuseres pĂ„?â, MONA, 2022(3)
Genome Analysis of a Transmissible Lineage of Pseudomonas aeruginosa Reveals Pathoadaptive Mutations and Distinct Evolutionary Paths of Hypermutators.
Genome sequencing of bacterial pathogens has advanced our understanding of their evolution, epidemiology, and response to antibiotic therapy. However, we still have only a limited knowledge of the molecular changes in in vivo evolving bacterial populations in relation to long-term, chronic infections. For example, it remains unclear what genes are mutated to facilitate the establishment of long-term existence in the human host environment, and in which way acquisition of a hypermutator phenotype with enhanced rates of spontaneous mutations influences the evolutionary trajectory of the pathogen. Here we perform a retrospective study of the DK2 clone type of P. aeruginosa isolated from Danish patients suffering from cystic fibrosis (CF), and analyze the genomes of 55 bacterial isolates collected from 21 infected individuals over 38 years. Our phylogenetic analysis of 8,530 mutations in the DK2 genomes shows that the ancestral DK2 clone type spread among CF patients through several independent transmission events. Subsequent to transmission, sub-lineages evolved independently for years in separate hosts, creating a unique possibility to study parallel evolution and identification of genes targeted by mutations to optimize pathogen fitness (pathoadaptive mutations). These genes were related to antibiotic resistance, the cell envelope, or regulatory functions, and we find that the prevalence of pathoadaptive mutations correlates with evolutionary success of co-evolving sub-lineages. The long-term co-existence of both normal and hypermutator populations enabled comparative investigations of the mutation dynamics in homopolymeric sequences in which hypermutators are particularly prone to mutations. We find a positive exponential correlation between the length of the homopolymer and its likelihood to acquire mutations and identify two homopolymer-containing genes preferentially mutated in hypermutators. This homopolymer facilitated differential mutagenesis provides a novel genome-wide perspective on the different evolutionary trajectories of hypermutators, which may help explain their emergence in CF infections
UniversitetspĂŠdagogikkens udvikling og aktuelle udfordringer
âUniversitetspĂŠdagogik â findes det?â Omtrent sĂ„dan reagerede en studerende for knap 20 Ă„r siden, da en af denne artikels forfattere fortalte, at vi arbejdede med universitetspĂŠdagogik. Dengang som nu er svaret ja â det gĂžr det. UniversitetspĂŠdagogik findes som noget, der forskes, udvikles og undervises indenfor, og den findes som en praksis, nĂ„r universitetsundervisere planlĂŠgger, gennemfĂžrer og evaluerer deres undervisning. UniversitetspĂŠdagogisk forskning og udvikling beskĂŠftiger sig med undervisning og undervisningsformer, med uddannelsernes opbygning og tilrettelĂŠggelse, med de studerendes og undervisernes baggrund, interesser og praksisser i forhold til universitetsuddannelser, med de politiske og strukturelle rammer omkring universitetsuddannelser og -undervisning og med diskussioner om uddannelsernes formĂ„l. UniversitetspĂŠdagogik gĂ„r sĂ„ledes pĂ„ tvĂŠrs af forskning og praksis og pĂ„ tvĂŠrs af flere fagomrĂ„der.
I denne artikel vil vi diskutere nogle af de dilemmaer og udfordringer, som universitetspÊdagogikken stÄr i. Vi skriver med udgangspunkt i vores erfaringer som forskere, undervisere og udviklere inden for universitetspÊdagogik gennem mere end 20 Är og som formand og nÊstformand i bestyrelsen for Dansk UniversitetspÊdagogisk NetvÊrk (DUN) i syv Är. Artiklen prÊsenterer vores refleksioner i lyset af andres og egen forskning og egne praksiserfaringer
The cost-effectiveness of venous-converted acid-base and blood gas status in pulmonary medical departments
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