Automated Feedback Can Improve Hypothesis Quality

Stating a hypothesis is one of the central processes in inquiry learning, and often forms the starting point of the inquiry process. We designed, implemented, and evaluated an automated parsing and feedback system that informed students about the quality of hypotheses they had created in an online tool, the hypothesis scratchpad. In two pilot studies in different domains (“supply and demand” from economics and “electrical circuits” from physics) we determined the parser's accuracy by comparing its judgments with those of human experts. A satisfactory to high accuracy was reached. In the main study (in the “electrical circuits” domain), students were assigned to one of two conditions: no feedback (control) and automated feedback. We found that the subset of students in the experimental condition who asked for automated feedback on their hypotheses were much more likely to create a syntactically correct hypothesis than students in either condition who did not ask for feedback

A Socio-Technical Approach to Information Security

The main objective of this paper is to present a preliminary socio-technical information security (STInfoSec) framework for the development of online information security applications that addresses both social and technical aspects of information security design. The paper looks at theoretical aspects related to a view of information security as a soci0-technical system in the context of online banking. The STInfoSec framework investigates usability and security requirements for an improved online banking system that seeks to improve the adoption and continued use of the service. The STInfoSec framework proposes 12 usable security design principles that assist in addressing security and usability requirements in online applications such as online banking. The framework seeks to influence the behaviour of designers of online information security applications by incorporating principles that consider the end user behaviour of such applications. The validation of the framework is beyond the scope of this paper

Assessing seasonal nitrogen export to large tropical lakes

Rivers are exporting increasing amounts of nitrogen (N) to lakes, which is leading to eutrophication. However, the seasonality apparent in nutrient loading, especially in tropical areas, is thus far only partially understood. This study aims to better understand the seasonality and the sources of dissolved inorganic nitrogen (DIN) inputs from sub-basins to tropical lakes. We integrated existing approaches into a seasonal model that accounts for seasonality in human activities, meteorology and hydrology, and we applied the model to the sub-basins of a representative tropical lake: Lake Tana, Ethiopia. The model quantifies the river export of DIN by season, source and sub-basin and also accounts for open defecation to land as a diffuse source of N in rivers. Seasonality parameters were calibrated, and model outputs were validated against measured nitrogen loads in the main river outlets. The calibrated model showed good agreement with the measured nitrogen loads at the outflow of the main rivers. The model distinguishes four seasons: rainy (July–September), post-rainy (October–December), dry (January–March) and pre-rainy (April–June). The river export of DIN to Lake Tana was about 9 kton in 2017 and showed spatial and temporal variability: It was highest in the rainy and lowest in the dry seasons. Diffuse sources from agriculture were important contributors of DIN to rivers in 2017, and animal manure was the dominant source in all seasons. Our seasonal sub-basins and rivers model provides opportunities to identify the main nutrient sources to the lake and to formulate effective water quality management options. An example is nutrient application level that correspond to the crop needs in the sub-basins. Furthermore, our model can be used to analyse future trends and serves as an example for other large tropical lakes experiencing eutrophication.</p

Students’ and Teachers’ Experiences With the Implementation of Problem-Based Learning at a University Law School

A few years ago, the Erasmus School of Law implemented problem-based learning (PBL) as an instructional method in the bachelor’s program. Transition to a PBL program often brings some difficulties for the teaching staff. To find out whether the implementation at the Erasmus School of Law has been successful, students and teachers were asked about their experiences with and perceptions of the PBL program. Both students and teachers reported positive study behaviors, such as regular studying and active involvement of students as a result of PBL. However, some issues also arose after implementing PBL: staff members reported dissatisfaction regarding the PBL program and students reported feelings of insufficient preparation for the legal profession. Recommendations on how to address these issues are discussed

Development and application of a positive–negative selectable marker system for use in reverse genetics in Plasmodium

A limitation of transfection of malaria parasites is the availability of only a low number of positive selectable markers for selection of transformed mutants. This is exacerbated for the rodent parasite Plasmodium berghei as selection of mutants is performed in vivo in laboratory rodents. We here report the development and application of a negative selection system based upon transgenic expression of a bifunctional protein (yFCU) combining yeast cytosine deaminase and uridyl phosphoribosyl transferase (UPRT) activity in P.berghei followed by in vivo selection with the prodrug 5-fluorocytosine (5-FC). The combination of yfcu and a positive selectable marker was used to first achieve positive selection of mutant parasites with a disrupted gene in a conventional manner. Thereafter through negative selection using 5-FC, mutants were selected where the disrupted gene had been restored to its original configuration as a result of the excision of the selectable markers from the genome through homologous recombination. This procedure was carried out for a Plasmodium gene (p48/45) encoding a protein involved in fertilization, the function of which had been previously implied through gene disruption alone. Such reversible recombination can therefore be employed for both the rapid analysis of the phenotype by targeted disruption of a gene and further associate phenotype and function by genotype restoration through the use of a single plasmid and a single positive selectable marker. Furthermore the negative selection system may also be adapted to facilitate other procedures such as ‘Hit and Run’ and ‘vector recycling’ which in principle will allow unlimited manipulation of a single parasite clone. This is the first demonstration of the general use of yFCU in combination with a positive selectable marker in reverse genetics approaches and it should be possible to adapt its use to many other biological systems

An optical lattice with sound

Funding: We acknowledge funding support from the Army Research Office. Y.G. and B.M. acknowledge funding from the Stanford Q-FARM Graduate Student Fellowship and the NSF Graduate Research Fellowship, respectively. S.G. acknowledges support from NSF Grant No. DMR-1653271.Quantized sound waves—phonons—govern the elastic response of crystalline materials, and also play an integral part in determining their thermodynamic properties and electrical response (for example, by binding electrons into superconducting Cooper pairs). The physics of lattice phonons and elasticity is absent in simulators of quantum solids constructed of neutral atoms in periodic light potentials: unlike real solids, traditional optical lattices are silent because they are infinitely stiff. Optical-lattice realizations of crystals therefore lack some of the central dynamical degrees of freedom that determine the low-temperature properties of real materials. Here, we create an optical lattice with phonon modes using a Bose–Einstein condensate (BEC) coupled to a confocal optical resonator. Playing the role of an active quantum gas microscope, the multimode cavity QED system both images the phonons and induces the crystallization that supports phonons via short-range, photon-mediated atom–atom interactions. Dynamical susceptibility measurements reveal the phonon dispersion relation, showing that these collective excitations exhibit a sound speed dependent on the BEC–photon coupling strength. Our results pave the way for exploring the rich physics of elasticity in quantum solids, ranging from quantum melting transitions to exotic ‘fractonic’ topological defects in the quantum regime.PostprintPeer reviewe

Entanglement and replica symmetry breaking in a driven-dissipative quantum spin glass

Funding: We are grateful for funding support from the Army Research Office, NTT Research, and the Q-NEXT DOE National Quantum Information Science Research Center. Surya Ganguli acknowledges funding from NSF CAREER award #1845166. B.M. acknowledges funding from the Stanford QFARM Initiative and the NSF Graduate Research Fellowship.We describe simulations of the quantum dynamics of a confocal cavity QED system that realizes an intrinsically driven-dissipative spin glass. A close connection between open quantum dynamics and replica symmetry breaking is established, in which individual quantum trajectories are the replicas. We observe that entanglement plays an important role in the emergence of replica symmetry breaking in a fully connected, frustrated spin network of up to 15 spin-1/2 particles. Quantum trajectories of entangled spins reach steady-state spin configurations of lower energy than that of semiclassical trajectories. Cavity emission allows monitoring of the continuous stochastic evolution of spin configurations, while backaction from this projects entangled states into states of broken Ising and replica symmetry. The emergence of spin glass order manifests itself through the simultaneous absence of magnetization and the presence of nontrivial spin overlap density distributions among replicas. Moreover, these overlaps reveal incipient ultrametric order, in line with the Parisi replica symmetry breaking solution for the Sherrington-Kirkpatrick model. A nonthermal Parisi order parameter distribution, however, highlights the driven-dissipative nature of this quantum optical spin glass. This practicable system could serve as a test bed for exploring how quantum effects enrich the physics of spin glasses.Peer reviewe

Entanglement and replica symmetry breaking in a driven-dissipative quantum spin glass

We describe simulations of the quantum dynamics of a confocal cavity QED system that realizes an intrinsically driven-dissipative spin glass. A close connection between open quantum dynamics and replica symmetry breaking is established, in which individual quantum trajectories are the replicas. We observe that entanglement plays an important role in the emergence of replica symmetry breaking in a fully connected, frustrated spin network of up to fifteen spin-1/2 particles. Quantum trajectories of entangled spins reach steady-state spin configurations of lower energy than that of semiclassical trajectories. Cavity emission allows monitoring of the continuous stochastic evolution of spin configurations, while backaction from this projects entangled states into states of broken Ising and replica symmetry. The emergence of spin glass order manifests itself through the simultaneous absence of magnetization and the presence of nontrivial spin overlap density distributions among replicas. Moreover, these overlaps reveal incipient ultrametric order, in line with the Parisi RSB solution ansatz for the Sherrington-Kirkpatrick model. A nonthermal Parisi order parameter distribution, however, highlights the driven-dissipative nature of this quantum optical spin glass. This practicable system could serve as a testbed for exploring how quantum effects enrich the physics of spin glasses.Comment: 23 pages including 11 figures and 8 appendices; section V and appendix F are ne