Experimental rationale for the use of fluids with different redox potential as a basis for infusion therapy

Objectives: To study the parameters of redox potential (ORP or Red-Ox) and pH of infusion solutions. To identify the general biological properties of ionized liquids with different ORP when administered by different methods to experimental animals and when applied to the wound surface. To study the effects of infusion therapy with solutions based on ionized fluids with various ORP in anaphylactic shock, bacterial sepsis, alcoholic hepatitis, dehydration, and skin injurie

Application of the Sensory Contact Model for Pharmacological Studies under Simulated Clinical Conditions

The sensory contact model allows forming different psycho-pathological states (anxious depression, catalepsy, social withdrawal, pathological aggression, cognition disturbances, anhedonia, addictive states etc.) produced by repeated agonistic interactions in male mice and investigating the therapeutic and preventive properties of any drug as well as its efficiency under simulated clinical conditions. This approach can be useful for a better understanding of the drugs’ action in different stages of disease development in individuals. It is suggested that this behavioral approach and pharmacological designs may be applied for the screening of novel psychotropic drugs. 
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Mechanisms of water-salt metabolism disturbances in dogs subjected to six month hypokinesia

Water-salt metabolism in dogs during prolonged restricted motor activity (hypokinesia) was investigated. It was found that hydration occurred and fluid was redistributed between the extra- and intra-cellular sectors. Also, electrolyte excretion rose, and magnetism and calcium metabolism changed significantly. It is concluded that the forces caused by muscle strain proper (which was decreased under conditions of hypokinesia) influence the state of bone metabolism