Slip of fluid molecules on solid surfaces by surface diffusion

The mechanism of fluid slip on a solid surface has been linked to surface diffusion, by which mobile adsorbed fluid molecules perform hops between adsorption sites. However, slip velocity arising from this surface hopping mechanism has been estimated to be significantly lower than that observed experimentally. In this paper, we propose a re-adsorption mechanism for fluid slip. Slip velocity predictions via this mechanism show the improved agreement with experimental measurements

Assessment of Cu, Pb and Zn contamination in sediment of north western Peninsular Malaysia by using sediment quality values and different geochemical indices

Surface sediments were collected from the north western aquatic area (13 intertidal sites and 5 river drainages) of Peninsular Malaysia, which were suspected to have received different anthropogenic sources. These sites included town areas, ports, fishing village, industrial areas, highway sides, jetties and some relatively unpolluted sites. The present study revealed that 4.79–32.91 μg/g dry weight for Cu, 15.85–61.56 μg/g dry weight for Pb, and 33.6–317.4 μg/g dry weight for Zn based on 13 intertidal surface sediments while those based on 5 river drainage surface sediments were 10.24–119.6 μg/g dry weight for Cu, 26.7–125.7 μg/g dry weight for Pb and 88.7–484.1 μg/g dry weight for Zn. In general, the metal levels in the drainage sediments are higher than in the intertidal sediments, suggesting dilution factor in the intertidal sediment and direct effluent from point sources in the drainage sediment. In particular, the total concentrations of Cu, Pb, and Zn for the sampling site at Kuala Kurau Town exceeded the Effect Range Median values for Cu, Pb, and Zn for assessments of sediment quality values for freshwater sediment as proposed by MacDonald et al. (Arch Environ Contam Toxicol 39:20–31, 2000), thus adverse biological effects would be observed above this level. Assessment using enrichment factor (using Fe as a normalizer) and geoaccumulation index showed that the three metals at Kuala Kurau Town and Juru Industry drainage were evidenced as having more enrichment and mostly due to non-natural sources. However, caution should be exercised that the interpretation can only become valid when the ratios, indices, and sediment quality values are combined. This is due to the fact that not all the established indices are applicable and, to a certain extent, some of them should be further revised and improved to suit a different metal for Malaysian sediment. Undoubtedly, sites near drainages at Kuala Kurau Town and Juru River Basin need greater attention to mitigate the heavy metal pollution in the future

Multi-level Attention Model for Weakly Supervised Audio Classification

In this paper, we propose a multi-level attention model to solve the weakly labelled audio classification problem. The objective of audio classification is to predict the presence or absence of audio events in an audio clip. Recently, Google published a large scale weakly labelled dataset called Audio Set, where each audio clip contains only the presence or absence of the audio events, without the onset and offset time of the audio events. Our multi-level attention model is an extension to the previously proposed single-level attention model. It consists of several attention modules applied on intermediate neural network layers. The output of these attention modules are concatenated to a vector followed by a multi-label classifier to make the final prediction of each class. Experiments shown that our model achieves a mean average precision (mAP) of 0.360, outperforms the state-of-the-art single-level attention model of 0.327 and Google baseline of 0.314.Comment: 5 pages, 3 figures, Submitted to Eusipco 201

Analysis of primary resistance mutations to HIV-1 entry inhibitors in therapy naive subtype C HIV-1 infected mother– infant pairs from Zambia

Background—Small molecular CCR5 inhibitors represent a new class of drugs for treating HIV-1 infection. The evaluation of the primary resistance mutations associated with entry inhibitors during HIV-1 perinatal transmission is required because they may have a profound impact on the clinical management in MTCT. Objectives—To evaluate the primary resistance mutations to maraviroc and vicriviroc during perinatal transmission and analyze the sensitivity of Env derived from mother–infant pairs to maraviroc. Study design—Nine MIPs infected by subtype C HIV-1 were recruited to analyze the prevalence and transmission of primary resistance mutations to maraviroc and vicriviroc. Moreover, Env derived from six MIPs were employed to construct provirus clones and to analyze the sensitivity to maraviroc. Results—Mutations A316T, conferring partial resistance to maraviroc, T307I and R315Q, both conferring partial resistance to vicriviroc are prevalent in mother and infant cohorts, indicating the transmission of primary resistance mutations during HIV-1 perinatal transmission. However, the mutations of acutely infected mothers seem to directly transmit to their corresponding infants, while some mutations at low frequency of chronically infected mothers would be lost during transmission. Moreover, provirus clones derived from acutely infected MIPs are less susceptible to maraviroc than those from chronically infected MIPs. Conclusions—Our study suggests that the transmission mode of primary resistance mutations and the sensitivity to maraviroc are dependent on infection status of MIPs either acutely or chronically infected. These results may indicate that higher dose of maraviroc could be needed for treatment of acutely infected MIPs compared to chronically infected MIPs