Citra Penjajahan Jepang di Indonesia yang Terpantul dalam Beberapa Novel Pramoedya

Images of Japanese troops which drawn by Pramoedya in his works indeed related with his own experiences. Pramoedya through his characters portrays his view on humanities. Pramoedya depicted the brutality of Japanese troops in their occupation in Indonesia. All Japanese propaganda delivered false messages and caused disasters for Indonesian people. Japanese culture retardation and their brutality made the author suffer and down. Even though his novels associate with anti Japanese occupation and patriotism among the youth, humanities issues in fact appear as a strong theme in all his works

The role of type 4 phosphodiesterases in generating microdomains of cAMP: Large scale stochastic simulations

Cyclic AMP (cAMP) and its main effector Protein Kinase A (PKA) are critical for several aspects of neuronal function including synaptic plasticity. Specificity of synaptic plasticity requires that cAMP activates PKA in a highly localized manner despite the speed with which cAMP diffuses. Two mechanisms have been proposed to produce localized elevations in cAMP, known as microdomains: impeded diffusion, and high phosphodiesterase (PDE) activity. This paper investigates the mechanism of localized cAMP signaling using a computational model of the biochemical network in the HEK293 cell, which is a subset of pathways involved in PKA-dependent synaptic plasticity. This biochemical network includes cAMP production, PKA activation, and cAMP degradation by PDE activity. The model is implemented in NeuroRD: novel, computationally efficient, stochastic reaction-diffusion software, and is constrained by intracellular cAMP dynamics that were determined experimentally by real-time imaging using an Epac-based FRET sensor (H30). The model reproduces the high concentration cAMP microdomain in the submembrane region, distinct from the lower concentration of cAMP in the cytosol. Simulations further demonstrate that generation of the cAMP microdomain requires a pool of PDE4D anchored in the cytosol and also requires PKA-mediated phosphorylation of PDE4D which increases its activity. The microdomain does not require impeded diffusion of cAMP, confirming that barriers are not required for microdomains. The simulations reported here further demonstrate the utility of the new stochastic reaction-diffusion algorithm for exploring signaling pathways in spatially complex structures such as neurons

Promises of the "Book of Hope" : influences on the new Malaysian government

For more about the East-West Center, see http://www.eastwestcenter.org/Tommy K. S. Koh, former Summer Affiliate Scholar at the East-West Center, explains that "Written as an opposition manifesto, Buku Harapan's desire for greater parliamentary engagement reflected what Pakatan Harapan desired from an expected ruling Barisan Nasional government.

Chain configurations in light nuclei

The model of nuclear matter built from alpha-particles is proposed. The strong deformed shape for doubly even N=Z nuclides from carbon to magnesium has been determined according to this model. In this paper we undertake very simple approach, which assumes the existence of low lying chain configurations.Comment: 6 pages, 5 figure

Stress relief as the driving force for self-assembled Bi nanolines

Stress resulting from mismatch between a substrate and an adsorbed material has often been thought to be the driving force for the self-assembly of nanoscale structures. Bi nanolines self-assemble on Si(001), and are remarkable for their straightness and length -- they are often more than 400 nm long, and a kink in a nanoline has never been observed. Through electronic structure calculations, we have found an energetically favourable structure for these nanolines that agrees with our scanning tunneling microscopy and photoemission experiments; the structure has an extremely unusual subsurface structure, comprising a double core of 7-membered rings of silicon. Our proposed structure explains all the observed features of the nanolines, and shows that surface stress resulting from the mismatch between the Bi and the Si substrate are responsible for their self-assembly. This has wider implications for the controlled growth of nanostructures on semiconductor surfaces.Comment: 4 pages, 4 figures, submitted to Phys. Rev. Let

Public Health Leadership In The 21st Century

Leadership in public health requires stretching the mind and soul in almost unimaginable ways. Living the dynamic tension of health as “part individual good served by medicine and part public good secured by public health activities” (Institute of Medicine, 2003a) represents a privilege and an awesome responsibility. Upholding the health of others requires complementing a foundation in science with skills in government, policy, media, economics, sociology, ethics and other dimensions. To survive and thrive, public health leaders must practice the “tactics of the transcendent” (Parks, 2005)