7 research outputs found
ΠΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² Ρ ΠΊΠΈΠ½Π΄Π»ΠΈΠ½Π³ΠΎΠ²ΡΡ ΠΊΡΡΡ ΠΈ ΡΡΡΠ΅ΠΊΡΡ ΠΏΠ΅Π½ΡΠΎΠΊΡΠΈΡΠΈΠ»Π»ΠΈΠ½Π°
Under condition of acute experiments on male Wistar rats it was shown that under condition of kindling formation induced via repeated subthreshold corazol administration (30,0 mg/kg, i.p.) the decreasing of blastogenic response induced by bacterial lypopolysaccharide and phytogemagglutinin was shown. This effect was detectable after 10-th convulsant injection and intensified in the course of kindling (21 injections of picrotoxin). Pentoxiphyllin (25,0 and 50,0 mg/kg, i.p.) caused antiseizure effects and effectively prevented kindling-induced decreasing of blastogenic response in dose-depended manner.Π ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΎΡΡΡΡΡ
ΠΎΠΏΡΡΠΎΠ² Π½Π° ΠΊΡΡΡΠ°Ρ
-ΡΠ°ΠΌΡΠ°Ρ
Π»ΠΈΠ½ΠΈΠΈ ΠΠΈΡΡΠ°Ρ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΏΡΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΠΊΠΈΠ½Π΄Π»ΠΈΠ½Π³Π° Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΏΠΎΠ²ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΏΠ΅ΡΠ²ΠΎΠ½Π°ΡΠ°Π»ΡΠ½ΠΎ ΠΏΠΎΠ΄ΠΏΠΎΡΠΎΠ³ΠΎΠ²ΠΎΠΉ Π΄ΠΎΠ·Ρ ΠΊΠΎΡΠ°Π·ΠΎΠ»Π° (30,0 ΠΌΠ³/ΠΊΠ³, Π²Π½ΡΡΡΠΈΠ±ΡΡΡΠΈΠ½Π½ΠΎ) ΠΏΡΠΎΠΈΡΡ
ΠΎΠ΄ΠΈΡ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΠΈ Π±Π»Π°ΡΡΠ½ΠΎΠΉ ΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΠΈ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ², Π²ΡΠ·ΡΠ²Π°Π΅ΠΌΠΎΠΉ Ρ ΠΏΠΎΠΌΠΎΡΡΡ Π±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π»ΠΈΠΏΠΎΠΏΠΎΠ»ΠΈΡΠ°Ρ
Π°ΡΠΈΠ΄Π° ΠΈ ΡΠΈΡΠΎΠ³Π΅ΠΌΠ°Π³Π³Π»ΡΡΠΈΠ½ΠΈΠ½Π°. ΠΠ°Π½Π½ΡΠΉ ΡΡΡΠ΅ΠΊΡ ΠΎΠ±Π½Π°ΡΡΠΆΠΈΠ²Π°Π΅ΡΡΡ ΠΏΠΎΡΠ»Π΅ 10 ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΉ ΠΊΠΎΠ½Π²ΡΠ»ΡΡΠ°Π½ΡΠ° ΠΈ Π΅Π³ΠΎ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡ ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Π΅ΡΡΡ ΠΏΡΠΈ ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΌ ΠΊΠΈΠ½Π΄Π»ΠΈΠ½Π³Π΅ (21 ΠΈΠ½ΡΠ΅ΠΊΡΠΈΡ). ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΏΠ΅Π½ΡΠΎΠΊΡΠΈΡΠΈΠ»Π»ΠΈΠ½Π° (25,0-50,0 ΠΌΠ³/ΠΊΠ³, Π²/Π±Ρ) ΠΏΡΠ΅Π΄ΠΎΡΠ²ΡΠ°ΡΠ°Π΅Ρ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΎΠ³Π΅Π½Π½ΡΡ
ΡΡΡΠ΅ΠΊΡΠΎΠ² ΠΊΠΎΡΠ°Π·ΠΎΠ»Π°, ΡΠΌΠ΅Π½ΡΡΠ°Π΅Ρ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡ ΡΡΡΠ΅ΠΊΡΠ° ΠΏΠΎΠ΄Π°Π²Π»Π΅Π½ΠΈΡ Π±Π»Π°ΡΡΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΠΈ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ²
ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠΈΠΌΡΠ»ΡΡΠΈΠΈ (ΡΡ) ΠΏΠ°Π»Π΅ΠΎΡΠ΅ΡΠ΅Π±Π΅Π»Π»ΡΡΠ½ΠΎΠΉ ΠΊΠΎΡΡ Π½Π° ΠΏΠ΅Π½ΠΈΡΠΈΠ»Π»ΠΈΠ½-Π²ΡΠ·Π²Π°Π½Π½ΡΠ΅ ΠΎΡΠ°Π³ΠΈ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π² ΠΊΠΎΡΠ΅ Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΠΊΠΈΠ½Π΄Π»ΠΈΠ½Π³ΠΎΠ²ΡΡ ΠΊΡΡΡ
Electrical stimulation (ES) (0,25 ms, 100 Hz, 150-250 mcΠ) of paleocerebellar cortex (pyramis and culmen) caused the suppression of epileptogenic foci, induced in frontal cortex via application of penicillin solution (16 000 IU/ml) to male Wistar rats in three weeks from the moment of last corazol kindled administration. Antiepileptic effects have been pronounced in form of suppression of amplitude and frequency of spikes as well as in the net shortening of life-span of foci. Lower and higher intensities of ES did not cause suppression of focal epileptogenesis.ΠΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΡΠΈΠΌΡΠ»ΡΡΠΈΡ (ΠΠ‘) (0,25 ΠΌΡ, 100 ΠΡ, 150-250 ΠΌΠΊΠ) ΠΏΠ°Π»Π΅ΠΎΡΠ΅ΡΠ΅Π±Π΅Π»Π»ΡΡΠ½ΠΎΠΉ ΠΊΠΎΡΡ (ΠΏΠΈΡΠ°ΠΌΠΈΠ΄Π½Π°Ρ Π΄ΠΎΠ»ΡΠΊΠ°, Π²Π΅ΡΡ
ΡΡΠΊΠ°), ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ΅ΠΌΠ°Ρ ΡΠ΅ΡΠ΅Π· ΡΡΠΈ Π½Π΅Π΄Π΅Π»ΠΈ ΠΏΠΎΡΠ»Π΅ ΠΏΠΎΡΠ»Π΅Π΄Π½Π΅Π³ΠΎ ΠΊΠΈΠ½Π΄Π»ΠΈΠ½Π³ΠΎΠ²ΠΎΠ³ΠΎ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΊΠΎΡΠ°Π·ΠΎΠ»Π° (30,0 ΠΌΠ³/ΠΊΠ³, Π²/Π±Ρ) ΠΊΡΡΡΠ°ΠΌ-ΡΠ°ΠΌΡΠ°ΠΌ Π»ΠΈΠ½ΠΈΠΈ ΠΠΈΡΡΠ°Ρ, ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π»Π°ΡΡ ΡΠ³Π½Π΅ΡΠ΅Π½ΠΈΠ΅ΠΌ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΠ°Π³ΠΎΠ², ΡΠΎΠ·Π΄Π°Π½Π½ΡΡ
Π² Π»ΠΎΠ±Π½ΠΈΡ
ΠΎΡΠ΄Π΅Π»Π°Ρ
ΠΊΠΎΡΡ Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° Π°ΠΏΠΏΠ»ΠΈΠΊΠ°ΡΠΈΠ΅ΠΉ ΡΠ°ΡΡΠ²ΠΎΡΠ° ΠΏΠ΅Π½ΠΈΡΠΈΠ»Π»ΠΈΠ½Π° (16 000 ΠΠ/ΠΌΠ»). ΠΡΠΎΡΠΈΠ²ΠΎΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π²ΡΡΠ°ΠΆΠ°Π»ΠΎΡΡ Π² ΠΏΠΎΠ΄Π°Π²Π»Π΅Π½ΠΈΠΈ ΡΠ°ΡΡΠΎΡΡ ΠΈ Π°ΠΌΠΏΠ»ΠΈΡΡΠ΄Ρ ΡΠ°Π·ΡΡΠ΄ΠΎΠ² Π² ΠΎΡΠ°Π³Π°Ρ
, ΡΠΎΠΊΡΠ°ΡΠ΅Π½ΠΈΠΈ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ ΠΈΡ
ΡΡΡΠ΅ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΡ. ΠΠ‘ ΠΌΠ΅Π½ΡΡΠ΅ΠΉ ΠΈΠ»ΠΈ Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠΎΠΊΠΎΠΉ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΠΈ Π½Π΅ Π²ΡΠ·ΡΠ²Π°Π»ΠΎ ΡΡΡΠ΅ΠΊΡΠ° ΠΏΠΎΠ΄Π°Π²Π»Π΅Π½ΠΈΡ ΠΎΡΠ°Π³ΠΎΠ²ΠΎΠΉ ΡΠΏΠΈΠ»Π΅ΠΏΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ
Pentoxifylline potentiates antiepileptic activity of diazepam on the model of treatment-resistant focal epilepsy
Kindling-syndrome was modeled in male Wistar rats using repeated corazole administration (25-30 mg/kg intraperitoneally). The effects of pentoxifylline (25 and 100 mg/kg intraperitoneally) and diazepam (0.05 and 1 mg/kg intraperitoneally) were studied in 3 weeks after kindling development under conditions of acute observation on the model of penicillin-induced foci in cerebral cortex. An anticonvulsant effect of combined treatment with diazepam and pentoxifylline in the doses, ineffective if administered separately (0.05 and 25 mg/kg intraperitoneally), was demonstrated. Β© 2013 Springer Science+Business Media New York
Are there different mechanisms of synchronization in the course of spike-wave discharges (SDS) burst development in WAG/Rij rats?
Contains fulltext :
56895.pdf ( ) (Open Access)In WAG/Rij rats the pair linear correlation r was calculated for bipolar recordings in fronto-temporal, fronto-occipital and occipito-temporal zones of both hemispheres as well as in paleocerebellar cortex (culmen). It was shown that development of SWD bursts resulted in interhemispheric decreases of correlation between the right occipito-temporal cortical region on one side, and left fronto-temporal on the contralateral side. Towards the end of SWD, we found an increased interhemispheric correlation between left fronto-temporal and right fronto-occipital cortical zones, as well as, between both fronto-temporal zones. Paleocerebellum correlates at a weak to moderate level during different periods of SWD burst generation;6 p
Pentoxifylline potentiates antiepileptic activity of diazepam on the model of treatment-resistant focal epilepsy
Kindling-syndrome was modeled in male Wistar rats using repeated corazole administration (25-30 mg/kg intraperitoneally). The effects of pentoxifylline (25 and 100 mg/kg intraperitoneally) and diazepam (0.05 and 1 mg/kg intraperitoneally) were studied in 3 weeks after kindling development under conditions of acute observation on the model of penicillin-induced foci in cerebral cortex. An anticonvulsant effect of combined treatment with diazepam and pentoxifylline in the doses, ineffective if administered separately (0.05 and 25 mg/kg intraperitoneally), was demonstrated. Β© 2013 Springer Science+Business Media New York
Functional relationships between brain and cerebellar cortex during absence and clonic seizures
Item does not contain fulltextThe relationships between frontal, temporal, and occipital zones of cortex of both hemispheres and paleocerebellar cortex in Wistar and WAG/Rij rats were investigated with an application of multiple linear regression analyses. Taking into consideration the dependence of epileptiform manifestations on sleep-wakefulness cycle, passive wakefulness state was used for data collection. The process of transition from absence to clonic seizure activity, which was provoked through the administration of sodium benzilpenicillin salt in WAG/Rij rats, was characterized as follows: 1) a preservation of high levels of interaction between brain structures in alpha band; 2) a pronounced decrease of interaction in delta and high-frequency rhythm bands; 3) moderate reduction of interaction between brain structures in the theta range. The increase of the number of connections of cerebellar cortex was marked in the course of transition from absence to clonic seizure activity, which might be in favor for the involvement of the cerebellum in the control of excitability of the brain.14 p