Progress in the Design of the Atacama Large Aperture Submillimeter Telescope

The Atacama Large Aperture Submillimeter Telescope (AtLAST) aims to be the premier next generation large diameter (50 meter) single dish observatory capable of observations across the millimeter/submillimeter spectrum, from 30~GHz to 1~THz. AtLAST will be sited in Chile at approximately 5100 meters above sea level, high in the Atacama Desert near Llano de Chajnantor. The novel rocking-chair telescope design allows for a unprecedentedly wide field of view (FoV) of 1-2$^\circ$ diameter, a large receiver cabin housing six major instruments, and high structural stability during fast scanning operations (up to $\sim 3^\circ$ per second in azimuth). Here we describe the current status of, and expected outcomes for, the antenna design study, which will be completed in 2024.Comment: Accepted for the URSI GASS 2023, Sapporo, Japan, 19-26 August 2023. 4 pages, 3 figure

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Treatment of internuclear ophthalmoparesis in multiple sclerosis with fampridine: A randomized double-blind, placebo-controlled cross-over trial

Aim: To examine whether the velocity of saccadic eye movements in internuclear ophthalmoparesis (INO) improves with fampridine treatment in patients with multiple sclerosis (MS). Methods: Randomized, double-blind, placebo-controlled, cross-over trial with fampridine in patients with MS and INO. Horizontal saccades were recorded at baseline and at multiple time points post-dose. Main outcome measures were the change of peak velocity versional dysconjugacy index (PV-VDI) and first-pass amplitude VDI (FPA-VDI). Both parameters were compared between fampridine and placebo using a mixed model analysis of variance taking patients as their own control. Pharmacokinetics was determined by serial blood sampling. Results: Thirteen patients had a bilateral and 10 had a unilateral INO. One patient had an INO of abduction (posterior INO of Lutz) and was excluded. Fampridine significantly reduced both PV-VDI (−17.4%, 95% CI: −22.4%, −12.1%; P < 0.0001) and FPA-VDI (−12.5%, 95% CI: −18.9%, −5.5%; P < 0.01). Pharmacokinetics demonstrated that testing coincided with the average t max at 2.08 hours (SD 45 minutes). The main adverse event reported after administration of fampridine was dizziness (61%). Conclusion: Fampridine improves saccadic eye movements due to INO in MS. Treatment response to fampridine may gauge patient selection for inclusion to remyelination strategies in MS using saccadic eye movements as primary outcome measure

CMB-HD: Astro2020 RFI Response

CMB-HD is a proposed ultra-deep (0.5 uk-arcmin), high-resolution (15 arcseconds) millimeter-wave survey over half the sky that would answer many outstanding questions in both fundamental physics of the Universe and astrophysics. This survey would be delivered in 7.5 years of observing 20,000 square degrees, using two new 30-meter-class off-axis cross-Dragone telescopes to be located at Cerro Toco in the Atacama Desert. Each telescope would field 800,000 detectors (200,000 pixels), for a total of 1.6 million detectors