Shaking Table Tests on Seismic Deformation of Composite Breakwaters

A series of shaking table tests were conducted on composite breakwater systems under 30g centrifugal conditions. The emphasis was placed on investigating the mechanisms of seismic settlement of foundation ground, in particular of the contribution from the dispersion of mound rubble into the foundation soil. In-flight visual observation of the deformation process by a high-speed CCD camera showed the significance of cumulative vertical compression of foundation soils under cyclic loading. Pre- and post-shaking comparisons of weight of the rubble mound revealed that dispersion into the soil had occurred and contributed to caisson settlement

暗所閾値電位の新しい記録方法の創案

取得学位：博士(医学), 学位授与番号：医博甲第1470号, 学位授与年月日：平成13年5月2日, 学位授与年：200

Effects of Choto-san (Diao-Teng-San) on microcirculation of bulbar conjunctiva and hemorheological factors in patients with asymptomatic cerebral infarction

In this study, the effects of Choto-san ( 釣藤散 ) on the microcirculation of bulbar conjunctiva in 16 patients with asymptornatic cerebral infarction were investigated with a video-microscopic system. After the administration of Choto-san for four weeks, variables of microcirculatory flow of the bulbar conjunctiva, that is, the internal diameter of vessels, flow velocity and flow volume rate were increased (p<0.05) . Erythrocyte aggregability, evaluated by measuring the maximum diameter of a column of intravascular erythrocyte aggregation, was also improved (p<0.05) . Simultaneously, hemorheological factors such as whole blood viscosity, plasrna viscosity, erythrocyte deformability and leukocyte deformability were examined. Choto-san improved deformability of both erythrocytes and leukocytes (p<0.05) , but not blood viscosity. These results suggest that Choto-san may have favorable effects on cerebrovascular disorders through changes in microcirculatory flow, erythrocyte aggregability and blood cell deformability. 今回,無症候性脳梗塞患者16名を対象に,眼球結膜微小循環に及ぼす釣藤散の効果をビデオ顕徴鏡システムを用いて検討した。釣藤散を4週間投与後,眼球結膜微小循環の血管内径,血流速度,血流量が増加した(p<0.05)。血管内赤血球集合現象を認める血管の最大内径で評価ざれる赤血球集合能も改善した(p<0.05)。同時に,血液レオロジー因子である全血粘度,血漿粘度,赤血球変形能,白血球変形能も検討したところ,釣藤散は赤血球と白血球の変形能を改善したが(p<0.05),血液粘度は改善しなかった。以上の結果から,釣藤散は徴小循環血流や赤血球集合能,血球変形能を改善することで,脳血管障害に好影響を与える可能性が示唆された

Correlation between "oketsu" syndrome and autonomic nervous activity : a diachronic study on the same subjects

In order to confirm that autonomic nervous activity changes with the change in the "oketsu" state using a diachronic study with the same subjects, 20 patients were evaluated by laser Doppler flowmetry and spectral analyses of the R-R intervals (RRs) and systolic blood pressure (SBP). According to the diagnostic criteria of "oketsu", the "oketsu" score (OS) was evaluated. After evaluation of OS and measurement of the parameters, each subject underwent his own Kampo treatment. Twelve weeks later, OS and the parameters were re-evaluated for each subject. The changes in OS and the parameters between week 0 and 12 weeks later were investigated, with the quantity of each change being calculated as Δ-. Δ-SBF showed a significant negative correlation with Δ-OS, and Δ-RR-L/H, Δ-SBP-LF and Δ-. SBP-L/H revealed significant positive correlations with Δ-OS. It is known that SBF changes with sympathetic nervous activity, and SBP-LF and SBP-L/H reflect α-sympathetic nervous activity. These results suggest that the significant relationship between OS and sympathetic nervous activity was maintained even after change in the "oketsu" state in the same subjects. 瘀血病態の経時的変化と自律神経活動の変化との関連性を明らかとするために,レーザードプラ血流計,R-R間隔および収縮期血圧のスペクトル解析を用いて検討した。患者20名を対象とし,瘀血スコアの変化と自律神経活動の変化との関連について統計学的に解析した。結果として,皮膚血流量(SBF)の変化量は瘀血スコアと負の相関を示し,R-R間隔成分比(RR-L/H)・収縮期血圧低周波成分(SBP-LF)・収縮期血圧成分比(SBP-L/H)は瘀血スコアと正の相関を示した。CVRR,・R-R間隔高周波成分(RR-HF)・収縮期血圧高周波成分(SBP-HF)については瘀血スコアとの間に有意な相関を認めなかった。SBFは交感神経活動にともない変化し,SBP-LFはα作動性交感神経活動と関連するとされている。今回の結果は,血病態がα作動性交感神経活動と密接に関連していることを示唆するものである

Identification of a Predictive Biomarker for the Beneficial Effect of Keishibukuryogan, a Kampo (Japanese Traditional) Medicine, on Patients with Climacteric Syndrome

Keishibukuryogan (KBG; Guizhi-Fuling-Wan in Chinese) is one of the Kampo (Japanese traditional) medicines used to treat patients with climacteric syndrome. KBG can be used by patients who cannot undergo hormone replacement therapy due to a history of breast cancer. We evaluated whether cytosine-adenine (CA) repeat polymorphism of the estrogen receptor β gene can be a predictor of the beneficial effect of KBG on climacteric syndrome. We also investigated the relationship between CA repeat polymorphism, the patients’ profiles, and the therapeutic effect. We found that CA was an SS, SL, or LL genotype according to the number of repeats. We studied 39 consecutive patients with climacteric disorders who took KBG for 12 weeks. The diagnosis of climacteric disorders was made on the basis of the Kupperman index. KBG significantly improved the patients’ climacteric symptoms (i.e., vasomotor symptoms in the patients with the LL genotype and melancholia in the patients with the SL genotype). No relationship between the patients’ profiles and CA repeat polymorphism was recognized. CA repeat polymorphism could thus be a potential biomarker to predict the efficacy of KBG in climacteric syndrome, and its use will help to reduce the cost of treating this syndrome by focusing the administration of KBG on those most likely to benefit from it

Equilibrium and kinetics of the unfolding of -lactalbumin by guanidine hydrochloride (IV): Dependence of the N equilibrium A transconformation on the temperature

The reversible unfolding from the native (N) state to the acid (A) state of α-lactalbumin by guanidine·HCl (0.8–2.0 M) was studied at 10–35 °C by means of difference spectra and pH-jump measurements. At each temperature, all points plotted as the logarithmic equilibrium constant log KNA of the N ⇌ A process against pH could fall on a curve independent of the denaturant concentration by shifting each point along the log KNA axis, where the shift factor ƒ did not depend on temperature. Moreover, by shifting the points at each temperature along the log () axis, a master curve, independent of both temperature and the denaturant concentration, could be obtained for the pH-dependence of log KNA. From the dependence of the logarithmic rate constants on pH, master curves independent of both temperature and the denaturant concentration could also be made for the and the processes, where A∗ means the activated state. The results show the two-state character of the N ⇌ A process.The enthalpy changes and the differences in heat capacity for the processes were determined from the accurate measurements of temperature dependence of the unfolding at pH 4.3 and 1.0 M guanidine·HCl. The results show that the disruption of hydrophobic interaction is caused mainly in the process, while most of the changes in the pK values of the ionizing groups are caused in the process