Structure-activity correlations for organophosphorus ester anticholinesterases. Part 2: CNDO/2 calculations applied to ester hydrolysis rates

Quantitative structure-activity relationships are presented for the hydrolysis of organophosphorus esters, RR'P(O)X, where R and R' are alkyl and/or alkoxy groups and X is fluorine, chlorine or a phenoxy group. CNDO/2 calculations provide values for molecular parameters that correlate with alkaline hydrolysis rates. For each subset of esters with the same leaving group, X, the CNDO-derived net atomic charge at the central phosphorus atom correlates well with the alkaline hydrolysis rate constants. For the whole set of esters with different leaving groups, equations are derived that relate charge, orbital energy and bond order to the hydrolysis rate constants

Project and production management Intersection: Life-Cycle analysis of on-site and off-site construction

The purpose of this paper is to provide an argument for moving beyond calls for increased construction industry productivity based on the perceived differences between construction projects and manufacture production. Traditionally scholars have claimed that the lack of increased construction industry productivity is attributable to the differences between on-site work and off-site work. However, in 2011 project processes and product outcomes are essential to both. As management theories have become integrated into practice in both industries, the management of both a unique project and product-production have converged. At the same time, almost all construction today utilises both on-site and off-site processes. Therefore, the driver for increased off-site manufacture to ensure increased industry productivity must be reconsidered. One way forward would be to consider issues related to reducing the environmental impacts of construction. That is the aim of this discussion paper. Many researchers have identified difficulties with communication between on-site and off-site production. However, if the focus of productivity gains shifts to measuring environmental impact, based on a Life-Cycle Analysis (LCA), then both the tangible and intangible effects of both on-site and off-site work can be compared. Thus, over-coming identified difficulties with a common language based on LCA could enable co-operative on and off site production. This co-operation could in turn to lead to increased industry productivity. The paper ends by providing a LCA focused research agenda to provide evidence for reconsidering the claim that increasing off-site manufacture will increase construction industry productivity

1924-25: Abilene Christian College Bible Lectures - Full Text

PREFACE The lectures in this volume were delivered in the auditorium of Abilene Christian College during the last week of February in 1924 and 1925. Not all of the lectures delivered during these two weeks are given here, some of those delivering lectures not having responded with their manuscripts. These are given to the public in the belief that the splendid sermons delivered here ought to be read by thousands of Christians who did not have the opportunity of hearing them. Many of those who heard them will desire to read them. May this contribution to the literature of Christian teaching from the minds of some of our best and most faithful laborers in the Master’s vineyard be a continued blessing to all whose lives they touch. BATSELL BAXTER. __________________ PUBLISHER’S ANNOUNCEMENT This volume of Abilene Christian College Lectures is the fourth and comprises the lectures for February 1924 and 1925. The lectures for 1919 were published in one volume, 1920 and 1921 were combined in one volume, as were also the lectures for 1922 and 1923. By putting the lectures for two years in one volume, the reader is saved the expense of an additional book in order to receive the full benefit of these lectures. That these discourses are of great value is recognized by thousands who have heard them orally or have read them on the printed page. Such carefully prepared addresses really and truly merit a permanent place in the literature of the brotherhood of the churches of Christ. They are filled with expositions and analyses of much benefit to younger brethren who are entering upon lines of public service for the church, and they contain instruction on the word of God that is of much value to those out of the church as well as those in the church. The four books comprising the Abilene Christian College Lectures will make a most valuable addition to all libraries. We are at this time, January, 1926, in position to furnish complete sets or any volume to complete any broken set that any of our readers may have. When our present supply is gone, the books will probably not be reprinted as no plates have been made, and the books will be scarce. The messages of hope and love contained in this volume will find their place into the homes of many thousands, and it is to be ardently hoped that they will be read attentively and that they may contribute much to the extension of the power and kingdom of our Lord and Savior Jesus Christ. G. II. P. SHOWALTER. Austin, Texas, January 1, 1926

Nomenclature for renal replacement therapy and blood purification techniques in critically ill patients: practical applications

This article reports the conclusions of the second part of a consensus expert conference on the nomenclature of renal replacement therapy (RRT) techniques currently utilized to manage acute kidney injury and other organ dysfunction syndromes in critically ill patients. A multidisciplinary approach was taken to achieve harmonization of definitions, components, techniques, and operations of the extracorporeal therapies. The article describes the RRT techniques in detail with the relevant technology, procedures, and phases of treatment and key aspects of volume management/fluid balance in critically ill patients. In addition, the article describes recent developments in other extracorporeal therapies, including therapeutic plasma exchange, multiple organ support therapy, liver support, lung support, and blood purification in sepsis. This is a consensus report on nomenclature harmonization in extracorporeal blood purification therapies, such as hemofiltration, plasma exchange, multiple organ support therapies, and blood purification in sepsis

Construction project cash flow modelling

The thesis investigates construction project cash flows. It is divided into two main components. The first investigates the cumulative gross cash flow profiles (S curves), and the second examines the cumulative net cash flow profiles. The gross cash flow model can be used by either construction industry clients or contractors, whereas the net cash flow model concerns the contractor. Interest in construction project cash flows resulted from changed economic pressures in the 1970s. A rise in inflation was associated with increased client attention to his gross cash flows to the contractor, and similarly higher interest rates had the effect that contractors became concerned with their net cash flows. An examination of the gross cash flow literature found that most models were aimed at discovering generally applicable ideal curves. A similar situation existed within the net cash flow literature. It was argued that the averaging approach is unsuitable for construction project cash flow research, and consequently an approach which concentrates on the individual project was pursued. A gross cash flow model was developed using logistic transformation regression procedures. This yielded excellent results for post-hoc analysis of individual project data. Furthermore the gross cash flow model was found to be suitable for the generation of a construction project net cash flow model, which was similarly oriented towards the post-hoc analysis of single projects. A measure of deviation was used which enabled the identification of projects for which the gross cash flow model was a poor fit. This same procedure was used to exclude projects from the net cash flow analysis. The results from the gross cash flow model analysis indicate that projects do vary considerably from one to another, and this supports the contention made that an individual approach to this research is necessary. The net cash flow model yields an excellent trend line for net cash flow on a project, and thus provides an excellent means for senior management to judge the quality of management employed on a projec

Strategic management of local government facilities

Abstract not available

The sustainable competitive advantage model for corporate real estate

C1 - Refereed Journal Articl