19 research outputs found
Vasopressinergic modulation of stress responses in the central amygdala of the Roman high-avoidance and low-avoidance rat
The central nucleus of the amygdala (CEA) is selectively involved in the passive component of the behavioral (immobility) and the accompanying parasympathetic response during conditioned, stressful environmental challenges. Vasopressinergic mechanisms in the brain seem to play a role in these stress responses. The effects of the neuropeptides arginine-8-vasopressin (AVP) and oxytocin (OXT) on modulating CEA activity during conditioned stress of inescapable footshock were studied in male Roman high-avoidance (RHA/Verh) and low-avoidance (RLA/Verh) rats, psychogenetically selected on the basis of shuttle-box acquisition behavior. In RLA/Verh rats, the cardiac and behavioral responses to the conditioned emotional stressor were bradycardia and immobility, suggesting an important role for the CEA in these rats. The RHA/Verh rats, however, failed to show any change in heart rate or immobility in response to a conditioned stress situation. The low dose of AVP (20 pg) in the CEA of conscious RLA/Verh rats caused an enhancement of the stress-induced bradycardiac and immobility response. However, the high dose of AVP (2 ng) and OXT (200 pg) attenuated the bradycardiac and immobility responses in the RLA/Verh rats. Infusion of AVP and OXT in the RHA/Verh rats failed to induce any change in heart rate nr immobility. Binding studies revealed that the AVP receptor selectively binds AVP with high affinity. In contrast, the OXT receptor recognizes both AVP and OXT with a similar (but lower) affinity. This suggests that the behavioral and autonomic responses of the high dose of AVP may be caused by OXT receptor stimulation. In conclusion, on the basis of the present results one may hypothesize that CEA differences in AVP and OXT innervation and/or receptor densities may contribute to the differences in coping strategy found in these animals.
Long-Time Behavior of Macroscopic Quantum Systems: Commentary Accompanying the English Translation of John von Neumann's 1929 Article on the Quantum Ergodic Theorem
The renewed interest in the foundations of quantum statistical mechanics in
recent years has led us to study John von Neumann's 1929 article on the quantum
ergodic theorem. We have found this almost forgotten article, which until now
has been available only in German, to be a treasure chest, and to be much
misunderstood. In it, von Neumann studied the long-time behavior of macroscopic
quantum systems. While one of the two theorems announced in his title, the one
he calls the "quantum H-theorem", is actually a much weaker statement than
Boltzmann's classical H-theorem, the other theorem, which he calls the "quantum
ergodic theorem", is a beautiful and very non-trivial result. It expresses a
fact we call "normal typicality" and can be summarized as follows: For a
"typical" finite family of commuting macroscopic observables, every initial
wave function from a micro-canonical energy shell so evolves that for
most times in the long run, the joint probability distribution of these
observables obtained from is close to their micro-canonical
distribution.Comment: 34 pages LaTeX, no figures; v2: minor improvements and additions. The
English translation of von Neumann's article is available as arXiv:1003.213