985 research outputs found
The Carnot Cycle for Small Systems: Irreversibility and the Cost of Operations
We employ the recently developed framework of the energetics of stochastic
processes (called `stochastic energetics'), to re-analyze the Carnot cycle in
detail, taking account of fluctuations, without taking the thermodynamic limit.
We find that both processes of connection to and disconnection from heat
baths and adiabatic processes that cause distortion of the energy distribution
are sources of inevitable irreversibility within the cycle. Also, the so-called
null-recurrence property of the cumulative efficiency of energy conversion over
many cycles and the irreversible property of isolated, purely mechanical
processes under external `macroscopic' operations are discussed in relation to
the impossibility of a perpetual machine, or Maxwell's demon.Comment: 11 pages with 3 figures. Resubmitted to Physical Review E. Many
paragraphs have been modifie
Adiabatic invariance with first integrals of motion
The construction of a microthermodynamic formalism for isolated systems based
on the concept of adiabatic invariance is an old but seldom appreciated effort
in the literature, dating back at least to P. Hertz [Ann. Phys. (Leipzig) 33,
225 (1910)]. An apparently independent extension of such formalism for systems
bearing additional first integrals of motion was recently proposed by Hans H.
Rugh [Phys. Rev. E 64, 055101 (2001)], establishing the concept of adiabatic
invariance even in such singular cases. After some remarks in connection with
the formalism pioneered by Hertz, it will be suggested that such an extension
can incidentally explain the success of a dynamical method for computing the
entropy of classical interacting fluids, at least in some potential
applications where the presence of additional first integrals cannot be
ignored.Comment: 2 pages, no figures (REVTeX 4
Lack of association of human leukocyte antigen-B7 with COPD and rate of decline in lung function
SummaryBackground: Although variation in the human leukocyte antigen (HLA) locus is associated with various diseases, there have been a limited number of studies that have examined the possible role of HLA in chronic obstructive pulmonary disease (COPD). Only HLA-B7 has been shown to be correlated with low forced expiratory volume in 1s (FEV1) in Caucasians; however, this finding has not been replicated. The aim of this study was to investigate the contribution of the HLA-B7 allele to COPD and to rate of decline of lung function.Methods: We determined the prevalence of HLA-B7 in a group of COPD patients and a non-obstructed control group of smokers by using a polymerase chain reaction-based genotyping assay. We also determined the prevalence of HLA-B7 in smokers selected from the National Heart Lung and Blood Institute, Lung Health Study for having the fastest and slowest decline of lung function.Results: No significant difference was found in the frequency of HLA-B7 between the COPD and non-obstructed groups. There was also no significant association of HLA-B7 with rate of decline of lung function.Conclusion: These data indicate that HLA-B7 does not contribute to COPD or rate of decline of FEV1 in smokers
Resistance of Mice to Infection with Friend Disease Virus After Subcutaneous Injection of Friend Virus and Friend Spleen-Cells
Swiss mice injected subcutaneously with suspensions of spleen cells or an extract of spleens from mice infected with Friend virus develop resistance to subsequent intravenous inoculation of Friend virus. A single injection of either Friend virus or Friend cells induces resistance. Immunized mice display resistance when challenged 6 months after immunization and survive for at least 20 weeks after infection. Neutralization tests indicate that serum, but not lymphoid cells of resistant animals, can neutralize Friend virus. In vitro neutralization tests indicate that residence of virus within the peritoneal cavity of immune mice for 1 h sharply reduces the infective titer of the virus
First isolation of Dysgonomonas mossii from intestinal juice of a patient with pancreatic cancer
ArticleARCHIVES OF MEDICAL RESEARCH. 37(7): 914-916 (2006)journal articl
First case of bacteremia due to chromosome-encoded CfxA3-beta-lactamase-producing Capnocytophaga sputigena in a pediatric patient with acute erythroblastic leukemia
ArticleEUROPEAN JOURNAL OF MEDICAL RESEARCH. 13(3): 133-135 (2008)journal articl
Novel Methodology for Creating Macaque Retinas with Sortable Photoreceptors and Ganglion Cells
Purpose: The ability to generate macaque retinas with sortable cell populations would be of great benefit to both basic and translational studies of the primate retina. The purpose of our study was therefore to develop methods to achieve this goal by selectively labeling, in life, photoreceptors (PRs) and retinal ganglion cells (RGCs) with separate fluorescent markers. Methods: Labeling of macaque (Macaca fascicularis) PRs and RGCs was accomplished by subretinal delivery of AAV5-hGRK1-GFP, and retrograde transport of micro-ruby™ from the lateral geniculate nucleus, respectively. Retinas were anatomically separated into different regions. Dissociation conditions were optimized, and cells from each region underwent fluorescent activated cell sorting (FACS). Expression of retinal cell type- specific genes was assessed by quantitative real-time PCR to characterize isolated cell populations. Results: We show that macaque PRs and RGCs can be simultaneously labeled in-life and enriched populations isolated by FACS. Recovery from different retinal regions indicated efficient isolation/enrichment for PRs and RGCs, with the macula being particularly amendable to this technique. Conclusions: The methods and materials presented here allow for the identification of novel reagents designed to target retinal ganglion cells and/or photoreceptors in a species that is phylogenetically and anatomically similar to human. These techniques will enable screening of intravitreally- delivered AAV capsid libraries for variants with increased tropism for PRs and/or RGCs and the evaluation of vector tropism and/or cellular promoter activity of gene therapy vectors in a clinically relevant species
Synthesis of titanate nanostructures using amorphous precursor material and their adsorption/photocatalytic properties
This paper reports on a new and swift hydrothermal chemical route to prepare
titanate nanostructures (TNS) avoiding the use of crystalline TiO2 as starting
material. The synthesis approach uses a commercial solution of TiCl3 as
titanium source to prepare an amorphous precursor, circumventing the use of
hazardous chemical compounds. The influence of the reaction temperature and
dwell autoclave time on the structure and morphology of the synthesised
materials was studied. Homogeneous titanate nanotubes with a high
length/diameter aspect ratio were synthesised at 160^{\circ}C and 24 h. A band
gap of 3.06\pm0.03 eV was determined for the TNS samples prepared in these
experimental conditions. This value is red shifted by 0.14 eV compared to the
band gap value usually reported for the TiO2 anatase. Moreover, such samples
show better adsorption capacity and photocatalytic performance on the dye
rhodamine 6G (R6G) photodegradation process than TiO2 nanoparticles. A 98%
reduction of the R6G concentration was achieved after 45 minutes of irradiation
of a 10 ppm dye aqueous solution and 1 g/L of TNS catalyst.Comment: 29 pages, 10 figures, accepted for publication in Journal of
Materials Scienc
Relating the thermodynamic arrow of time to the causal arrow
Consider a Hamiltonian system that consists of a slow subsystem S and a fast
subsystem F. The autonomous dynamics of S is driven by an effective
Hamiltonian, but its thermodynamics is unexpected. We show that a well-defined
thermodynamic arrow of time (second law) emerges for S whenever there is a
well-defined causal arrow from S to F and the back-action is negligible. This
is because the back-action of F on S is described by a non-globally Hamiltonian
Born-Oppenheimer term that violates the Liouville theorem, and makes the second
law inapplicable to S. If S and F are mixing, under the causal arrow condition
they are described by microcanonic distributions P(S) and P(S|F). Their
structure supports a causal inference principle proposed recently in machine
learning.Comment: 10 page
Shapes, contact angles, and line tensions of droplets on cylinders
Using an interface displacement model we calculate the shapes of
nanometer-size liquid droplets on homogeneous cylindrical surfaces. We
determine effective contact angles and line tensions, the latter defined as
excess free energies per unit length associated with the two contact lines at
the ends of the droplet. The dependences of these quantities on the cylinder
radius and on the volume of the droplets are analyzed.Comment: 26 pages, RevTeX, 10 Figure
- …