Entrepreneurial intention of undergraduate students of G. B. Pant University of Agriculture and Technology, Pantnagar

Entrepreneurship can positively impact human resource market by creating employment and economic opportunity, something that is of urgent need. Agriculture sector has immense untapped potential and huge busi-ness prospects for young entrepreneurs. Thus, to have an insight into these issues present study was undertaken to find out the socioeconomic, personal and psychological characteristics of undergraduate students along with their entrepreneurial intention. The study was conducted at College of Agriculture, G.B.P.U.A. and T. Pantnagar. Fifty five students from each, third year and final year of B.Sc. Agriculture were selected as respondents through simple random sampling technique using chit method. Analytical research design was used for the present study. Detailed pre-tested questionnaire was administered to 110 respondents for collection of data. Findings of the study revealed that majority of the respondents (60.91 %) belonged to middle age group and were female (55.55 %), belonged to general caste (60.91 %) and had received their basic education in English (72.73 %). Regarding the entrepreneurial intention of undergraduate students of agriculture, it was found that majority of the respondents (59.09 %) had mod-erate level of entrepreneurial intention, while 23.64 % of the respondents had low entrepreneurial intention and only 17.27 % students had high entrepreneurial intention. The findings of this study may help all stakeholders (policy makers, researchers, private institutions, entrepreneurship educators and youth development practitioners) who are concerned with developing youth entrepreneurship in the country

Awareness of ethical problems in the global context

This paper seeks to help deans and faculties of colleges and schools of education in India to develop a global perspective for teacher education. The article explains the urgent need for a global approach to both the general and professional components of teacher education --- teaching and learning methods as well as clinical and practical training Indian education, despite its failure to cope with current realities, possesses an enviable record for responding to new social, economic, and cultural demands.  The provision for local needs the willingness to experiment and reform and the continual search for equal educational opportunity, provide optimism that education for a global age lies within reach. The same processes and technology that have allowed unprecedented human interaction on a global scale could help correct Indian education’s current isolation from the rest of the world Global education offers a response to the challenges posed by modern, global realities.  Its ultimate goal is not the evolution of a world community governed by a super state, but the development of a comprehension of the differences and similarities within humankind, of how peoples’ actions reflect their perceptions of reality, of the stock and distribution of Earth’s resources, and of the concepts of interdependence, global conflict, equity, and human rights

People’s Perception about Gender Equity at RHTC, Naila, Jaipur

Gender equality refers to the equal rights, responsibilities, and opportunities of women and men, as well as girls and boys (United Nations Women, 2012). Women in India have suffered gender disparities since ages; although addressed at all fronts (social, political) for last few decades yet we can find scars here and there in the form of gender violence, honor-killing, rape, and social policing. Changes toward equitable gender roles and relations in the community as well as household are a prerequisite to gender equality Promotion of gender equality and empowering of women is one of the eight Millennium Development Goals (MDG) to which India is a signatory. Gender equality and women‘s empowerment are two sides of the same coin: progress toward gender equality requires women‘s empowerment and women‘s empowerment requires increases in gender equality evident by pairing of them in MDG

De novo Discovery of Novel Long Noncoding RNAs in the North American Beaver

Long noncoding RNAs (lncRNAs) are RNA molecules that are at least 200 nucleotides long and do not encode proteins. lncRNAs have roles in gene regulation, chromatin epigenetics, and molecular scaffolding. In light of mounting evidence implicating species-specific noncoding RNAs and gene regulatory mechanisms in species adaptations, it is reasonable to speculate that species-specific lncRNAs may underlie some of the adaptations seen in mammalian evolution. The genome and transcriptome of the North American beaver (Castor canadensis, a keystone species of northwest wetlands) have recently been sequenced for the first time, enabling a search for genomic adaptations of this unique semi-aquatic herbivore. The objective of this study was to identify novel lncRNAs in the beaver using a computational analysis of high throughput sequencing data from Oregon State University’s recently-released beaver genome and a pan-tissue composite transcriptome that we obtained from 16 tissues from a beaver. We found 182 novel lncRNAs and 113 lncRNAs with a known ortholog in another species. Nine candidate lncRNAs stood out for having the strongest evidence across the various performance measures. One novel lncRNA (contig62060.1) was the only putative novel multi-exonic lncRNA we detected. These novel lncRNAs may serve as a basis for hypothesis generation for targeted functional investigations

Mutation Studies of KRAS Proto oncogene and In Silico Drug Designing against Non-Small Cell Lung Cancer

Based upon the microscopic appearance of the tumor cells, Lung cancers, also known as bronchogenic carcinomas, are broadly classified into two types: small cell lung cancers (SCLC) and non-small cell lung cancers (NSCLC). Lung cancer is the significant contributor of increased cancer deaths. It is evident that the pathway of lung cancer includes both RAS-mediated and non-RAS-mediated mechanisms. Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10–30% of adenocarcinomas. Many of the mutations of KRAS have been reported worldwide to be involved in Non small cell Lung cancer. The current study involves checking the occurrence of one of these SNPs (rs104894361) in the target population. The work is further extended by investigating the role of natural antioxidants in inhibiting the mutated KRAS thereby reducing the cell proliferation rate. The work involves collection of Blood samples from various lung cancer patients along with their case history and medication details. The blood sample is processed further for DNA isolation, KRAS gene amplification and sequencing. While grouping the samples for processing, emphasis was given on their smoking status and it was concluded that smoking increases the possibility of target SNP hence leading to NSCLC. Further in in silico work a comprehensive analysis of KRAS at genomic and Proteomic level was conducted and docking studies were performed on mutated KRAS with screened Antioxidants. A comparative assessment of the docking energies revealed that many antioxidants like 2-Cys peroxiredoxin BAS1, Ascorbate peroxidase, Lectin and Lactoferrin have a better docking interaction with mutated KRAS than Trimetrixate, the conventional drug against NSCLC

Journey of dengue in Rajasthan in the last 15 years (2001-2015) with special reference to 2015

Introduction: Dengue is an underestimated and under-reported disease. We have analyzed the last 15 years data of dengue reported in Rajasthan with special reference to the year 2015 to assess the trends. Materials and Methods: This observational, descriptive study was conducted during January 2016-August 2016. Secondary data were collected from Integrated Disease Surveillance Programme (IDSP) Cell, Directorate, Medical and Health, Jaipur, the website of National Vector Borne Disease Control Programme, Census 2011. Reports of P form and L form and line listing of dengue cases of 2015 were collected. Results: Rajasthan had 1452 laboratory-confirmed cases in 2001 and 1850 in 2006 after a gap of 6 years. The next surge came only after 3 years gap. Recently, there was a fourfold increase (>4000 cases/year) during 2013 and 2015. There were substantial dengue deaths till 2009, but thereafter, it never crossed the figure of 10. Surprisingly five districts, i.e., Bhilwara, Chittorgarh, Jhalawar, Pali, and Sirohi, did not report a single case of dengue during 2015. There was fourfold increase in dengue cases but paradoxically fourfold decrease in malaria cases in the last 5 years. Conclusion: Dengue was the new emerging disease with 1452 confirmed cases in Rajasthan in 2001. Thereafter, there was a constant high load of dengue; however, case-fatality rate is below one after 2010. Recently, there was a fourfold increase (>4000 cases/year) during 2013 and 2015. Zero reporting of dengue in a few districts indicates the need for improvement in IDSP reporting in these districts

Next generation DNA led technologies

This brief highlights advances in DNA technologies and their wider applications. DNA is the source of life and has been studied since a generation, but very little is known as yet. Several sophisticated technologies of the current era have laid their foundations on the principle of DNA based mechanisms. DNA based technologies are bringing a new revolution of Advanced Science and Technology. Forensic Investigation, Medical Diagnosis, Paternity Disputes, Individual Identity, Health insurance, Motor Insurance have incorporated the DNA testing and profiling technologies for settling the issues

Bioinformatics of non small cell lung cancer and the ras proto-oncogene

Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10–30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies. This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken

Gender Preferences for Off Springs and its Association with Socio-Demographic Factors Among Married Women in a Slum Area of Jaipur City: A Cross Sectional Study

Introduction: The preference for a male child is still very common in India. Strong desire for a son and discrimination against the female child are resulting for skewed sex ratio in India. The present study was planned with objective to assess the gender preference its association with socio-demographic factors among married women of reproductive age group in an urban slum of Jaipur city.Materials and Methods: A community based cross sectional study was carried out in an urban slum (Kathputlinagar) of Jaipur, Rajasthan from June 2016 to August 2017. Total 1230 married women of age group 15 to 49 years were interviewed using a predesigned semi structured questionnaire to collect information regarding gender preference and its associated factors. Results: 53.3% women had preference for male child. Religion and socioeconomic status had significant association with male gender preference while age, and occupation were not significantly associated with gender preference. Total number of living children and gender composition of living children was significantly associated with gender preference. Conclusion: Preference to male child over female child had been observed and associated factors were Religion, socioeconomic status, total number of living children and gender composition of living children