22 research outputs found
Service Quality Management of Scenic Spot Based on Tourists\u27 Experience--Taking the Three Gorges Dam 5A Scenic Area for Example
Based on the perspective of tourists, the paper takes the empirical analysis of service quality of the three gorges dam scenic spot, tries to put forward some methods to improve service quality, and provide the reference for the tourism sustainable optimization development of the three gorges dam
Branched <i>versus </i>linear:Side-chain effect on fluorinated wide bandgap donors and their applications in organic solar cells
A silver nanocube on a gold microplate as a well-defined and highly active substrate for SERS detection
Actinorectispora metalli sp. nov., a novel actinomycete isolated from a mine and emended description of the genus Actinorectispora
Huzhang Tongfeng Granule Improves Monosodium Urate-Induced Inflammation of Gouty Arthritis Rat Model by Downregulation of Cyr61 and Related Cytokines
Objective. Gouty arthritis (GA) is a noninfectious inflammatory disease characterized by self-limited and severe pain. Huzhang Tongfeng granule is one of the most effective traditional Chinese medicines in the treatment of acute GA. However, its effects on the inflammatory factors in the process of acute gout inflammation remain unknown. In the present study, we aimed to evaluate the effect of Huzhang Tongfeng granule on the expressions of Cyr61 and related inflammatory factors in both experimental gout models in vivo and in vitro. Methods. Huzhang Tongfeng granule was provided by the pharmaceutical preparation room of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine. The expressions of Cyr61, IL-1β, TNF-α, and IL-6 in monosodium urate- (MSU-) induced rat models and fibroblast-like synoviocytes (FLSs) were determined by RT-PCR, Western blotting analysis, ELISA, immunohistochemistry, and hematoxylin and eosin staining. Results. Huzhang Tongfeng granule could downregulate the expressions of IL-1β, TNF-α, and IL-6 to some extent by inhibiting the expression of Cyr61. Conclusions. Collectively, our findings indicated that Cyr61 was highly expressed in rat models of gout. By inhibiting the expression of Cyr61, Huzhang Tongfeng granule could partially attenuate the inflammation induced by MSU crystal
Solvent Vapor Annealing-Mediated Crystallization Directs Charge Generation, Recombination and Extraction in BHJ Solar Cells
Small-molecule
(SM) donors that can be solution-processed with
fullerene acceptors (e.g., PC<sub>61</sub>/<sub>71</sub>BM), or their
“nonfullerene” counterparts, are proving particularly
promising for the realization of high-efficiency bulk-heterojunction
(BHJ) solar cells. In several recent studies, solvent vapor annealing
(SVA) protocols have been found to yield significant BHJ device efficiency
improvements via structural changes in the active layer morphologies.
However, the mechanisms by which active layer morphologies evolve
when subjected to SVA treatments, and the structural factors impacting
charge generation, carrier transport, recombination, and extraction
in BHJ solar cells with SM donors and fullerene acceptors, remain
important aspects to be elucidated. In this report, we show thatî—¸in
BHJ solar cells with SM donors and fullerene acceptorsî—¸selective
crystallization promoted by SVA mediates the development of optimized
morphologies across the active layers, setting domain sizes and boundaries.
Examining BHJ solar cells subjected to various SVA exposure times,
with BDTÂ[2F]ÂQdC as the SM donor and PC<sub>71</sub>BM as the acceptor,
we connect those morphological changes to specific carrier effects,
showing that crystal growth effectively directs charge generation
and recombination. We find that the SM donor-pure domains growing
at the expense of a mixed donor–acceptor phase play a determining
role, establishing optimum networks with 10–20 nm sized domains
during the SVA treatment. Longer SVA times result in highly textured
active layers with crystalline domains that can exceed the length
scale of exciton diffusion, while inducing detrimental vertical morphologies
and deep carrier traps. Last, we emphasize the field-dependence charge
generation occurring upon SVA-mediated crystallization and link this
carrier effect to the mixed phase depletion across the BHJ active
layer
Protective effect of ganoderan on renal damage in rats with chronic glomerulonephritis
Purpose: To investigate the protective effect of ganoderan on renal damage in rat models with chronic glomerulonephritis induced by adriamycin.
Methods: 48 healthy Sprague-Dawley rats were randomly divided into three groups: control, nephritic model and ganoderan treatment groups. Changes of the following indices in the three groups were observed 6 weeks after treatment: 24-hour urine protein, albumen, serum creatinine, cholesterol. Histopathological observations of the renal cortex were made by light and electron microscopy.
Results: Compared with controls, levels of 24-hour urine protein (9.60±0.57mg/d vs. 82.50±3.18mg/d), serum creatinine (35.25±2.63?mol/L vs. 44.75±8.06?mol/L) and cholesterol (1.15±0.10mmol/L vs. 4.02±0.25mmol/L) of rats in the nephritic model group were increased (P < 0.05), and the concentration of albumen was decreased (35.98±1.34g/L vs. 19.05±0.62g/L, P < 0.05). Ganoderan administration decreased 24-hour urine protein (82.50±3.18mg/d vs. 45.01±3.94mg/d, P < 0.05). Following ganoderan, the pathological changes in kidney tissue were improved compared with those in the nephritic model group.
Conclusion: Ganoderan exerts protective effects in rats with chronic glomerulonephritis induced by ADR. Ganoderan reduced 24-hour urine protein, serum creatinine, cholesterol, improving renal function and reducing the severity of renal injury