Validation of less-invasive hemodynamic monitoring with Pulsioflex in critically ill patients

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Metal-Substituted Microporous Aluminophosphates

This chapter aims to present the zeotypes aluminophosphates (AlPOs) as a complementary alternative to zeolites in the isomorphic incorporation of metal ions within all-inorganic microporous frameworks as well as to discuss didactically the catalytic consequences derived from the distinctive features of both frameworks. It does not intend to be a compilation of either all or the most significant publications involving metal-substituted microporous aluminophosphates. Families of AlPOs and zeolites, which include metal ion-substituted variants, are the dominant microporous materials. Both these systems are widely used as catalysts, in particular through aliovalent metal ions substitution. Here, some general description of the synthesis procedures and characterization techniques of the MeAPOs (metal-contained aluminophosphates) is given along with catalytic properties. Next, some illustrative examples of the catalytic possibilities of MeAPOs as catalysts in the transformation of the organic molecules are given. The oxidation of the hardly activated hydrocarbons has probably been the most successful use of AlPOs doped with the divalent transition metal ions Co2+, Mn2+, and Fe2+, whose incorporation in zeolites is disfavoured. The catalytic role of these MeAPOs is rationalized based on the knowledge acquired from a combination of the most advanced characterization techniques. Finally, the importance of the high specificity of the structure-directing agents employed in the preparation of MeAPOs is discussed taking N,N-methyldicyclohexylamine in the synthesis of AFI-structured materials as a driving force. It is shown how such a high specificity could be predicted and how it can open great possibilities in the control of parameters as critical in catalysis as crystal size, inter-and intracrystalline mesoporosity, acidity, redox properties, incorporation of a great variety of heteroatom ions or final environment of the metal site (surrounding it by either P or Al)

Fulminante pancreatitis door hypertriglyceridemie bij gebruik van quetiapine

An important cause of hypertriglyceridemia in psychiatric patients is the administration of antipsychotics. Mildly elevated levels of triglycerides are seen most often, occurring shortly after treatment inception. Whether hypertriglyceridemia may be caused by alcohol use has not been fully elucidated. We describe the case of a 38-year-old woman suffering from schizophrenia who had been prescribed quetiapine for five years and consumed two glasses of alcohol daily. Upon presentation with stomach pain, lab results showed alarming triglyceride levels (8348 mg/dl). She rapidly developed both a severe pancreatitis and thrombotic thrombocytopenic purpura (ttp). We discuss how this most severe case of pancreatitis and ttp in a patient on an antipsychotic described in the literature to date should encourage prevention and early management of hypertriglyceridemia in psychiatric patients

Study of the coordination of Cu2+ in zeolite Y: Interaction with water and ammonia

The ligand field spectrum of Cu(II ) exchanged zeolite Y, obtained after saturation with H2O and NH3 and during the gradual desorption of these ligands, was measured by diffuse reflectance spectroscopy (DRS). DFT and ab-initio calculations on several model clusters were performed to interpret the spectra. The structure of the model clusters was optimized by means of density functional theory (DFT), using the B3LYP functional. The electronic spectra of the models were calculated using multiconfigurational perturbation theory based on a CASSCF wavefunction (CASPT2) and compared with the DRS spectra. Firstly, several [Cu(NH3)y(H2O)x]2+ complexes were studied. It was shown that in fully hydrated Cu(II )Y, a [Cu(H2O)6]2+ complex can be present in the cages of the zeolite. In Cu(II )Y, saturated with NH3, the [Cu(NH3)4]2+ complex is present, but the Cu2+ center in this complex must still be coordinated to one or two lattice oxygens in the zeolite. Secondly, calculations were performed on large cluster models, representing the adsorption complexes of one H2O or one NH3 ligand on Cu2+ in the six-ring sites in zeolite Y. The ligand field spectrum of partially dehydrated and deammoniated Cu(II )Y shows d–d transitions at a lower energy than the spectrum of fully dehydrated Cu(II )Y, which is confirmed by the CASPT2 results of the six-ring clusters