Lipid Peroxides and α-Tocopherol in Rat Streptozotocin-Induced Diabetes Mellitus

Measurement of lipid peroxides and alpha-tocopherol was undertaken in rats with streptozotocin-induced diabetes. In sera and livers in diabetic rats, the lipid peroxides increased but alpha-tocopherol decreased. To study the effect of vitamin E deficiency in the diabetic state, diabetes was induced in rats maintained on a vitamin E deficient diet. Serum lipid peroxides increased greatly but alpha-tocopherol decreased. Lipid peroxides and alpha-tocopherol increased in the liver of vitamin E deficient states. In the liver, vitamin E deficient diabetic rats had lower lipid peroxides levels but higher alpha-tocopherol levels than vitamin E deficient non-diabetic rats. On the basis of the present experiments, it was considered that the decrease of alpha-tocopherol might be due to consumption as an antioxidant as lipid peroxides increased in sera and livers. The decrease of lipid peroxides in the liver was thought to play an important part of the increase in serum lipid peroxides.</p

A Cross-Sectional Study of the Psychological Needs of Adults Living with Cystic Fibrosis

<div><p>Background</p><p>Depression and anxiety are prevalent in people with cystic fibrosis (CF), yet psychological services are rarely accessible in CF clinics. This cross-sectional single center study reports on a psychological needs assessment of people with CF.</p><p>Methods</p><p>We asked adults attending a CF clinic, without integrated psychological services, to complete a psychological needs assessment survey that included items on: a) past access to psychological services (via a CF referral service), b) concerns relevant to discuss with a psychologist, and c) their likelihood of accessing psychological services if available at the CF clinic, and standardized measures of depression (CES-D) and anxiety (GAD-7).</p><p>Results</p><p>We enrolled 49 participants and 45 (91.8%) completed the survey. Forty percent reported elevated symptoms of depression and 13% had elevated anxiety. A majority of individuals (72.2% and 83.3%, respectively) indicated they would be likely to use psychological services, if available at the clinic. Concerns considered most relevant to discuss with a psychologist were: 1) worries (51.1%), 2) mood (44.4%), 3) life stress (46.6%), 4) adjustment to CF (42.2%), 5) life transitions (42.2%) and 6) quality of life (42.2%).</p><p>Conclusions</p><p>This study highlights the rationale for screening adults with CF for depression and anxiety, and to facilitate provision of psychological services and preventative mental health interventions as an integral component of multi-disciplinary CF care.</p></div

Characteristics of study participants (n = 45)^*.

<p>*Unless indicated otherwise</p><p>Characteristics of study participants (n = 45)^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0127944#t001fn001" target="_blank">*</a>}.</p

Additional file 2: of Self-management interventions to improve skin care for pressure ulcer prevention in people with spinal cord injuries: a systematic review protocol

MELDINE search strategy. List of search terms for the search strategy to run in MEDLINE. (DOCX 14.5 kb

Past access to psychological services as part of CF care and likelihood of accessing psychological services if made available.

<p><i>Note</i>: n = 45 participants completed the CES-D and n = 44 completed the GAD7).</p><p>*P-values displayed are unadjusted. None of the adjusted (Holm’s) p-values were significant.</p><p>In bold: p-values for which effect sizes (Phi coefficient) were moderate (≥ 0.30).</p><p>^† Responses to this item were collapsed into two groups (‘Never or Rarely’ and ‘Occasionally or Often’) given the distribution of the data.</p><p>^β Responses to this item were collapsed into two groups (‘Likely’/ ‘Unlikely’) given the distribution of the data. Data was missing for one participant on this item.</p><p>Past access to psychological services as part of CF care and likelihood of accessing psychological services if made available.</p