140 research outputs found
æ¥æ¬ãšãã¥ãŒãžãŒã©ã³ãã«ããããã¬ã€ã»ã³ã¿ãŒåå è ã®æŽ»åå¹æã«é¢ããç 究
The purpose of this paper was investigate the effect of parents\u27 Playcentre participation in Japan, and to compare the impact of different Japan and New Zealand Playcentre participants. The focus was on social networks, and theformation of trust and norm of reciprocity generating social capitals which operates to empower parents themselves, their families and communities. Japanese parents with preschool aged children in the Picasso Playcentre (Tokyo area) and Eniwa Playcentre (Hokkaido, the northern island of Japan) were interviewed. The findings are interpreted as follows: Japanese parents being involved in adult education and Playcentre activities was significantly associated with positive outcomes with regards to child-rearing attitudes and diverse other contemporary Japanese social problems. These were compared with Satoh\u27s own research in New Zealand and findings from the NZPF commissioned research Powell et al. (2005), The Effect of Adult Playcentre Participation on the Creation of Social capital in Local Communities.1
ã©ãŒãã³ã°ïœ¥ã¹ããŒãªãŒ 㪠ã¢ãã€ã¿ ã³ãœãã ã·ãšã³ (ããã¯ïœ¥ãã§ãŠã«ïœ¥ã«ã³ãã¡ã¬ã³ã¹) : ãã¥ãŒãžãŒã©ã³ã ã ãžãã»ã³ ããŠã³ã¯ 㪠ããŠãžã
æ¬çš¿ã¯ããã¥ãŒãžãŒã©ã³ãã®ä¿è²æã幌çšåãªã©ã®å¹Œå
æè²æœèšã蚪åããèšé²ãè©äŸ¡ãä¿è²èšç»ã®ããæ¹ã«ã€ããŠå ±åãããã®ã§ããã蚪åããèŠå¯å
ã§ã¯ã©ãã®æœèšã«ãããŠãã©ãŒãã³ã°ã»ã¹ããŒãªãŒãçšããŠã®ä¿è²èšé²ãè¡ã£ãŠãããæ¹å®åŸã®ä¿è²æä¿è²æéã«ãããŠã¯ãä¹³å
ãïŒæ³ä»¥äžïŒæ³æªæºå
ãžã®ä¿è²ã«ã€ããŠã®ãããåã³å
容ã瀺ããããšãšãã«ãä¿è²è
ãšå®¶åºïŒä¿è·è
ïŒãšã®é£æºã匷調ãããŠãããæ¥æ¬ã«ãããŠãæªæºå
ã®ä¿è²ããŸããŸãäžè¬åãããŠãããªãã§ãä¿è²è
ãæ
ã圹å²ãšããŠãä¿è·è
ãšã®é¢ãããåè²ãŠæ¯æŽã®éèŠæ§ãå¢ããŠãããæ¬å ±åã§ã¯ããã¥ãŒãžãŒã©ã³ãã§å®è·µãããŠããèšé²ã»è©äŸ¡ã»ã«ã³ãã¡ã¬ã³ã¹ã®å®éã玹ä»ãããšãšãã«å®¶åºãšã®é£æºã«ã€ããŠãèšåããŠãã
ä¿è²ã»ä»è·åŽåã®çŸç¶ãšèª²é¡ ãã®4 : ä¿è²æã«ãããå°ååè²ãŠæ¯æŽã®å®æ 調æ»ãéããŠ(人æã»ç€ŸäŒç§åŠç³»)
ããåœã§ã¯ã瀟äŒæ§é ã®å€åãšãšãã«ãåè²ãŠããããç°å¢ã倧ããå€å®¹ããããã€ãŠãåè²ãŠã¯ãå°åå
±åäœã®ãªãã§ã®æå¡å士ã«ããçžäºæ¶å©ãæ¡å€§å®¶æã«ãããç¥ç¶æ¯ã®ãµããŒãã«ããæç«ããŠãããçŸä»£ã§ã¯ãéœåžéšãäžå¿ã«æ žå®¶æäžåž¯ãå€ããå ããåšå®
芪åã®å°åã«ããããå€ç«åãã瀟äŒåé¡ãšãªã£ãŠãããè¿å¹Žã«ãªããšãæ¹æ£å
ç«¥çŠç¥æ³ãæ°ä¿è²æä¿è²æéã«ãããŠãä¿è²æãå°åå
šäœã®äžæ žãšãªãä¿è²è³æºã§ãããšæèšããããªã©ãä¿è²æã«ãããåè²ãŠæ¯æŽã®åœ¹å²æåŸ
ã倧ããåºãã£ãŠãããããªãã¡ããã®ããšã¯ãä¿è²å£«ã«å¯Ÿããæ¥åã®å€æ§åãæå³ããŠãããä¿è²å£«ã®åœ¹å²ã«ä¿è²æã®å
¥æå
ããã®èŠªã ãã§ãªããå°åã®èŠªåã«å¯ŸãããµããŒãæ¥åãå«ãŸããããã«ãªã£ãããšã瀺ããŠãããããã§ãæ¬çš¿ã§ã¯ãåšå®
芪åã«åããä¿è²æã®åè²ãŠæ¯æŽäºæ¥ã«çç®ããããéŠéœåã®çæ倧åŠãåæ¥ããä¿è²å£«ã察象ãšããã¢ã³ã±ãŒã調æ»ãããšã«ããã®å®æ
ãæããã«ããäœæ¥ãè©Šã¿ããçµæãšããŠãä¿è²æã«ãããæ¯æŽäœå¶ã®éçã確èªãããä»åŸã®åè²ãŠæ¯æŽæŽ»åã«ãããŠãä¿è²å£«ã ãã«åž°çããªãã芪èªèº«ã»å°åæå¡ãããŠä¿è²è
ã®é£æºã«ããçžäºæ¶å©æŽ»åã®å®æœããŸããŸãéèŠãšãªãããšã瀺ããã
æ¥æ¬åãã¬ã€ã»ã³ã¿ãŒã«å¯Ÿããã»ã³ã¿ãŒä»£è¡šè ãšåå 家åºã«ãã掻åè©äŸ¡
æ¬èª¿æ»ã¯ã芪ã«ããååä¿è²æŽ»åã§ãããã¥ãŒãžãŒã©ã³ãã®ãã¬ã€ã»ã³ã¿ãŒãã¢ãã«ãšããŠ2002幎ãã掻åãå§ãŸã£ãæ¥æ¬ã®ãã¬ã€ã»ã³ã¿ãŒæŽ»åã«å¯Ÿããè©äŸ¡ããããã«éãåå è
ãšã»ã³ã¿ãŒä»£è¡šè
ã察象ã«è³ªåçŽã«ãã£ãŠå®æœãããåå ãã芪ãã¡ã¯ããã¬ã€ã»ã³ã¿ãŒã®æŽ»åãéããŠãåè²ãŠã®ä»²éãå¢ãããåŠã³ããçµéšãéããŠãå©ãåãã®ç²Ÿç¥ãåã©ãã«å¯Ÿããç解ãšç¥èãç²åŸããŠããããšãããã£ããããããªãããããåœã§ã¯ããã¬ã€ã»ã³ã¿ãŒãå
šåœã§10æ°ãæãšæŽ»åã®å Žãå°ãªãããããã¬ã€ã»ã³ã¿ãŒã®æŽ»åãæªã äžè¬ã«ã¯åšç¥ãããŠããããåå ãå§ããã°ããã®èŠªãã¡ã«æŽ»åã®ç念ãç解ããã¥ããçŸç¶ãããããšãæãããšãªã£ããä»åŸã¯ãããªããã¬ã€ã»ã³ã¿ãŒã®æ®å掻åãåºå ±æŽ»åãæ±ãããããšãšãã«ãã芪ãæé·ãããããšãå¯èœã«ãããã¬ã€ã»ã³ã¿ãŒã®äŸ¡å€ãçŸåšæŽ»åäžã®èŠªãéããŠäžè«ã«åºããŠããå¿
èŠãããããšã瀺åããã
ãšãŠããšã³ ãã§ãŠã€ã¯ ãšãŠãªã§ãŠ ããªã±ã« ãªã§ãŠã€ã ã«ã³ãã§ãŠïœ£ ã ãã³ã»ã³ ã«ã〠ãã«ã³ã¹ã« ã±ã³ãã¥ãŠ : ãã§ãŠã€ã¯ ãã€ãšãŠ ã ãã¯ã·ã ã ãã³ãšãŠ ã ã·ã§ãŠã㳠㪠ã¢ãã
æ¬ç 究ã§ã¯ã1948ïŒæå23ïŒå¹Žã«çºè¡ããããä¿è²èŠé â幌çšåæè²ã®æåŒãããã2017幎ïŒå¹³æ29ïŒå¹Žã«æ¹èšãšãªã£ãçŸè¡ã®å¹Œçšåæè²èŠé ã«è³ããŸã§ã®é åãç°å¢ãã«é¢ããèšè¿°å
容ã«ã€ããŠã®åæãè¡ãããŸãã瀟äŒçãªèæ¯ã«ã觊ããªãããé åãç°å¢ãã®æè²å
容ãã©ã®ãããªå€é·ã®éçšããã©ã£ãŠããã®ããæ¢ãããã®ç¹è³ªã«ã€ããŠãæ瀺ããŠãã
ãã¬ã€ã»ã³ã¿ãŒã«ããã乳幌å æã®èŠªååç»ã®åšãæ¹ã«é¢ããç 究 : SPACEããã°ã©ã ãå®æœããããšã®æ矩ãšä»åŸã®æ¹åæ§
æ¬çš¿ã§ã¯ããã¥ãŒãžãŒã©ã³ãã®ãã¬ã€ã»ã³ã¿ãŒã§å§ãŸã£ã乳幌å
åãã®æ°ããªããã°ã©ã ãšãªãSPACEã«çç®ãç 究ãé²ããŠããã調æ»ã®ç®çã¯ãSPACEã®æŽ»åãéããŠ1.åå ãã芪åãå°åã®æ©é¢ãšã€ãªããåããæã¡ã2.仲éãã€ãããªãã芪ãšããŠã®èªä¿¡ãç²åŸããŠããã®ãã3.åã©ãã®åŠã¶æš©å©ãä¿éãã乳幌å
æãã幌å
æè²ã«åå ããæ©äŒãæäŸããŠããã®ããæ¢æ±ããããšã«ãããããåœã§ã¯ã2015幎4æããåã©ãã»åè²ãŠæ¯æŽæ°å¶åºŠãæœè¡ãããåšå®
芪åãäœå¹Žéœ¢å
ããã家åºã«å¯Ÿããæ¯æŽãå°åãæ ç¹ãšããåè²ãŠæ¯æŽããŸããŸã匷åãããæ¹åã«ãããæ¬è«æã«ãããŠã¯ãSPACEã®åãçµã¿ãå ±åããªãããæ¥æ¬åœå
ã«ãããã¬ã€ã»ã³ã¿ãŒäºæ¥ãæ°å¶åºŠäžã®åã©ãã»åè²ãŠæ¯æŽäºæ¥ãžã®æŽ»çšã®å¯èœæ§ãèžãŸããŠèå¯ãå ããŠãã
å°±åŠåã«ãªãã¥ã©ã ããã»ãã¡ãªãããçšããä¿è²å®è·µã«é¢ããäºäŸç 究 : ã©ãŒãã³ã°ã»ã¹ããŒãªãŒãšãã芳å¯èšé²ææ³ã«çç®ããŠ
ã©ãŒãã³ã°ã»ã¹ããŒãªãŒãšã¯ããã¥ãŒãžãŒã©ã³ãã®å€ãã®æè²ãä¿è²çŸå Žã«ãããŠçšããããŠãã芳å¯èšé²ã®äžã€ã®æ¹æ³ã§ãããæ¬ç 究ã§ã¯ãCä¿è²å(åŸã«å¯Ÿè±¡å
ã¯ãPä¿è²åã«è»¢åãPä¿è²åã«ãããŠã調æ»ãç¶ç¶)ã«ãããŠãåœæ4æ³å
ã§ãã£ããªãªã³ã®2幎éã芳å¯ãããå
·äœçã«ã¯ãKä¿è²å£«ã«ã©ãŒãã³ã°ã»ã¹ããŒãªãŒã®ææ³ã«åºã¥ãã芳å¯èšé²ãèç©ããŠããããå®æçã«åå
šäœã§æ¯ãè¿ãæ©äŒãèšããããããŠã1 ãã®èšé²ããã¥ãŒãžãŒã©ã³ãã®å¹Œå
æè²ã«ãªãã¥ã©ã ã§ããããã»ãã¡ãªãããšæ¥æ¬ã®ãä¿è²æä¿è²æéãã®åæ¹ãšç
§åããããšã«ãã£ãŠä¿è²å£«èªèº«ã®ä¿è²èŠ³ã«åœ±é¿ãå€åãããããã®ãã2 芳å¯èšé²ã§åŸãããææã次ã®æ¥ããã®ä¿è²å®è·µã«æŽ»ããããšã«ãããåã©ãã®çºéã«å¹æãè¡šããã®ããåæãããã©ãŒãã³ã°ã»ã¹ããŒãªãŒã«èšããããªãªã³ã®æŽ»åãããã»ãã¡ãªãããšç
§åããçµæãä¿è²è
ã«å¯ŸããŠã¯ããä¿è²ã客芳çã«èŠ³ãåããšãåã©ãã®å
ãªã声ãèŽãåããé€æããŠããããšãæ確ãšãªã£ãããŸãã察象å
ã®çºéé¢ã§ãå€åãèŠããããšããã瀟äŒæ§ãšè¡šçŸèœåã®äž¡é¢ãè²ãŸããŠãã
ãŽã£ã¯ããªãŒã»ãã¬ã€ã»ã³ã¿ãŒã«ãããJapanese Sessionã®å é§çå®è·µ
æ¬çš¿ã§ã¯ããã¥ãŒãžãŒã©ã³ãããã«ãœã³åžã®ãŽã£ã¯ããªãŒã»ãã¬ã€ã»ã³ã¿ãŒã§Japanese Session(以äžãæ¥æ¬èªã»ãã·ã§ã³ãšèšã)ãéå¬ããããããœãœãã調æ»å¯Ÿè±¡ãšããŠããã調æ»ã§ã¯ããã¥ãŒãžãŒã©ã³ãã«ãããŠæ¥æ¬äººããã¬ã€ã»ã³ã¿ãŒæŽ»åãããããšã®æ矩ãæ¥æ¬ã®æŽ»åè
ãšã®çžéãæããã«ããããšãéããŠãæ¥æ¬ã«ããããã¬ã€ã»ã³ã¿ãŒæŽ»åãžã®ç€ºåãåŸãããšãç®çãšããŠããã調æ»æ¹æ³ã¯ãã¹ãŒããŒãã€ã¶ãŒãã¡ãåå ãã芪ãã¡ãžã®èŽãåã調æ»ãã°ã«ãŒãã€ã³ã¿ãã¥ãŒåã³è³ªåçŽèª¿æ»ãè¡ãããšãšããæ¥æ¬èªã»ãã·ã§ã³èšçœ®ã«è³ããŸã§ã®çµç·¯ã察象è
ã®å±æ§ãšæŽ»åã«å¯Ÿããæèã掻åè©äŸ¡ã課é¡ãæ±è² ãªã©ã確èªããããã®çµæãšããŠãã©ã¡ãã®åœã®åå è
ãã芪åãäžç·ã«æŽ»åããå
±ã«æé·ãããããšããã仲éã¥ããã®æ ç¹ãšããŠãã¬ã€ã»ã³ã¿ãŒã掻çšããããšãã掻åãéããŠæãéããããŠããããšãããã£ããä»å調æ»ãè¡ã£ãæ¥æ¬èªã»ãã·ã§ã³ããããœãœãã§ã¯ãã»ãã·ã§ã³ããªãŒãããã¹ãŒããŒãã€ã¶ãŒãã掻åãåæ»ã«ããããã®äžå¿äººç©ãšãªã£ãŠããããŸãããã¬ã€ã»ã³ã¿ãŒãšããã·ã¹ãã ããã§ã«ãã¥ãŒãžãŒã©ã³ã瀟äŒã®ãªãã§äžå®ã®å°äœãåŸãŠããããšããã¬ã€ã»ã³ã¿ãŒã®éã³ç°å¢ãåžžèšã§ç¢ºä¿ãããŠããç¹ãããããœãœãã®æŽ»åçºå±ãžã®å©åãšãªã£ãŠããã以äžã®ããšããã芪ãäž»äœçã«æŽ»åã§ããããã«éå¶ã®äžæ¯ãã«åã人æã確ä¿ããããšããã¬ã€ã»ã³ã¿ãŒå°çšã®æœèšãçšæããããšããæ¥æ¬åœå
ã®ãã¬ã€ã»ã³ã¿ãŒæŽ»åã«ã¯æ±ããããããšãæãããšãªã£ããä»æ¹ãæ¥æ¬èªã»ãã·ã§ã³ããããœãœãã«ãããŠã¯ã芪åãã®åŠç¿ããªããªã浞éããªãåŸåã«ãããããã芪åŠç¿ããšã芪ã«ããååéå¶ããããã«åŸ¹åºãããŠããããšããä»åŸã®ããããœãœãã«èª²ãããã課é¡ã§ããããšã瀺ãããçµæãšãªã£ã
The Golgin Tether Giantin Regulates the Secretory Pathway by Controlling Stack Organization within Golgi Apparatus
Golgins are coiled-coil proteins that play a key role in the regulation of Golgi architecture and function. Giantin, the largest golgin in mammals, forms a complex with p115, rab1, GM130, and soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs), thereby facilitating vesicle tethering and fusion processes around the Golgi apparatus. Treatment with the microtubule destabilizing drug nocodazole transforms the Golgi ribbon into individual Golgi stacks. Here we show that siRNA-mediated depletion of giantin resulted in more dispersed Golgi stacks after nocodazole treatment than by control treatment, without changing the average cisternal length. Furthermore, depletion of giantin caused an increase in cargo transport that was associated with altered cell surface protein glycosylation. Drosophila S2 cells are known to have dispersed Golgi stacks and no giantin homolog. The exogenous expression of mammalian giantin cDNA in S2 cells resulted in clustered Golgi stacks, similar to the Golgi ribbon in mammalian cells. These results suggest that the spatial organization of the Golgi ribbon is mediated by giantin, which also plays a role in cargo transport and sugar modifications
- âŠ