Solubility Correlations of Common Organic Solvents

We describe general organic solvent solubility correlations derived from methodology that analyzed 63 240 pieces of automation-enabled solubility data of pharmaceutically relevant compounds and synthetic intermediates. A total of 1125 solubility screening panels were empirically collected on 905 distinct solutes using an Unchained Laboratories (formerly Symyx and Freeslate) automated solubility workflow over the last 15 years. Mining and analyzing these results revealed statistically significant solubility correlations between many solvent pairs and hierarchical clustering of most common organic solvents. This has enabled more efficient experimental solubility surveys by reducing the number of solvents in the experimental design, resulting in savings of both material and throughput

Solubility Correlations of Common Organic Solvents

We describe general organic solvent solubility correlations derived from methodology that analyzed 63 240 pieces of automation-enabled solubility data of pharmaceutically relevant compounds and synthetic intermediates. A total of 1125 solubility screening panels were empirically collected on 905 distinct solutes using an Unchained Laboratories (formerly Symyx and Freeslate) automated solubility workflow over the last 15 years. Mining and analyzing these results revealed statistically significant solubility correlations between many solvent pairs and hierarchical clustering of most common organic solvents. This has enabled more efficient experimental solubility surveys by reducing the number of solvents in the experimental design, resulting in savings of both material and throughput

Solubility Correlations of Common Organic Solvents

We describe general organic solvent solubility correlations derived from methodology that analyzed 63 240 pieces of automation-enabled solubility data of pharmaceutically relevant compounds and synthetic intermediates. A total of 1125 solubility screening panels were empirically collected on 905 distinct solutes using an Unchained Laboratories (formerly Symyx and Freeslate) automated solubility workflow over the last 15 years. Mining and analyzing these results revealed statistically significant solubility correlations between many solvent pairs and hierarchical clustering of most common organic solvents. This has enabled more efficient experimental solubility surveys by reducing the number of solvents in the experimental design, resulting in savings of both material and throughput

Metodika počítačové podpory návrhu úchopných mechanických efektorů průmyslových robotů

Import 20/04/2006Prezenční výpůjčkaVŠB - Technická univerzita Ostrava. Fakulta strojní. Katedra (354) robototechnik

Visualization 1: Iterative reconstruction of scene depth with fidelity based on light field data

the 3D surface reconstruction of Flower Originally published in Applied Optics on 10 April 2017 (ao-56-11-3185

Three-Dimensional Macroporous TiO₂‑MXene Nanostructure-Based Films for Flexible Freestanding Sulfur Cathodes

Flexible freestanding electrodes with high energy density and good cycling stability are of great importance for wearable devices. Lithium–sulfur battery is considered a promising next-generation energy storage system owing to its high theoretical energy density and low production cost. However, several issues such as the severe polysulfide shuttle effect, poor electrical conductivity, and drastic volume change of sulfur cathodes hindered the commercialization of lithium–sulfur batteries. To solve these problems, many recent studies have focused on a class of two-dimensional (2D) MXene nanomaterials with abundant surface functional groups and excellent mechanical flexibility. Although these unique MXene nanomaterials have chemical affinity and are easily designed into various nanostructures, the inevitable overlap of the nanosheets can impair their electrochemical performance. Herein, we develop a three-dimensional (3D) macroporous TiO2-MXene nanostructure-based film for the flexible freestanding sulfur cathode in this paper. Such structure can realize a dual-confined strategy for polysulfides, that is, physical barrier and chemical absorption. The hollow porous MXene nanostructure can physically inhibit the polysulfide shuttle effect. And the TiO2 nanoparticles on the surface of MXene can effectively anchor and catalyze polysulfides in the electrochemical reaction. Moreover, the 3D conductive MXene network can provide fast electronic pathways, which promote the electrochemical reaction and reduce the electrochemical polarization. Without adding additional binders and conductive agents, the 3D macroporous TiO2-MXene freestanding nanostructure-based film S@TiO2-Ti3C2Ox shows good electrochemical performances with a specific capacity of 1022.7 and 523.7 mAh/g at 0.1 and 1C, respectively. This work provides a possible application of lithium–sulfur batteries in the field of flexible electronic devices

Analytical parameters for direct and indirect UV detection of BCAAs.

<p>Analytical parameters for direct and indirect UV detection of BCAAs.</p

Expression of insulin-like growth factor 2 (IGF-2) in breast cancer.

*<p>r_s = 0.4756, P<0.0001;</p>#<p>r_s = 0.2845, P = 0.0238;</p>⊿<p>r_s = 0.3474, P = 0.005.</p

Quantitation of underivatized branched-chain amino acids in sport nutritional supplements by capillary electrophoresis with direct or indirect UV absorbance detection - Fig 2

<p>Indirect UV detection of BCAAs affected by the concentration of PAS (A) and the wavelength (B). The optimization process in A was obtained by different PAS concentration in 40.0 mM β-CD, 2.0 mmol/L Na₂HPO₄ (pH12.2), and detected at 264 nm. The separation profiles in B were at optimal BGE. Sample: 1.0 mmol/L Leu, Ile and Val. Others as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0179892#pone.0179892.g001" target="_blank">Fig 1</a>.</p

Quantitation of underivatized branched-chain amino acids in sport nutritional supplements by capillary electrophoresis with direct or indirect UV absorbance detection - Fig 3

<p>Identification of BCAAs in hydrolysates of the sports nutrition supplements by direct (A) and indirect (B) UV detection mode. The hydrolysates were 20- and 50-fold dilution, respectively for direct and indirect UV detection. Optimal BGE and others as in Figs <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0179892#pone.0179892.g001" target="_blank">1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0179892#pone.0179892.g002" target="_blank">2</a>.</p