Effect of various concentrations of WRK, Warn G20D and WarnF14V on Jurkat cells.

<p>Results are expressed as the percentage of cell permeabilization in comparison to the negative (PBS buffer) and positive (0.1% Triton X-100) controls. Experiments were performed in triplicates, and the results are expressed as means. Bar scales indicate standard deviations.</p

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<p><b>(A)</b> Light microscopy image of Jurkat cell. The straights line reveals the contrast due to the nucleus. <b>(B)</b> Cluster average spectra from HCA results. <b>(C)</b> Chemical image of Jurkat cell building from the HCA results. The colors correspond to the Raman spectra generated by HCA methods (see B) and characteristic of the different cell compartments (see description in the text). Arrows allow to highlight the differences between cells treated and untreated by the peptides.</p

Chemical images of MNC cells before the peptide injection noted (MNC) and 1 hour after injection of the different peptides (notified by + peptide name).

<p>Scale bars are notified in each image. The colors correspond to the Raman spectra generated by HCA methods and characteristic of the different cell compartments.</p

Median lethal dose (LD₅₀) of WRK on cancer cell lines tested.

<p>Median lethal dose (LD₅₀) of WRK on cancer cell lines tested.</p

Effect of various concentrations of WRK on leukemia cell lines Jurkat, KG1 and K562.

<p>Results are expressed as the percentage of cell permeabilization in comparison to the negative (PBS buffer) and positive (0.1% Triton X-100) controls. Experiments were performed in triplicates, and the results are expressed as means. Bar scales indicate standard deviations.</p

Primary sequences and biological activities of WRK and analogs WarnG20D and WarnF14V.

<p>Primary sequences and biological activities of WRK and analogs WarnG20D and WarnF14V.</p