(E)-2,2′-[3-(2-Nitro­phen­yl)prop-2-ene-1,1-di­yl]bis­(3-hy­droxy­cyclo­hex-2-en-1-one)

In the title compound, C21H21NO6, each of the cyclo­hexenone rings adopts a half-chair conformation. Each of the pairs of hy­droxy and carbonyl O atoms are oriented to allow for the formation of intra­molecular O—H⋯O hydrogen bonds, which are typical of xanthene derivatives

Economic Routing of Electric Vehicles using Dynamic Pricing in Consideration of System Voltage

There is a growing market for electric vehicles (EVs) in recent years. Due to this, many studies on electric vehicles are in progress and research on charging operations for EVs are especially active. Recent research trends on electric vehicle routes rely on the stochastic modelling of various factors such as convenience of a user&rsquo s point of view, charging station (CS), location, destination, and so on. In this paper, a charging control scheme for electric vehicles is proposed from the point of view of the system operators rather than the user. From a user&rsquo s point of view, the EV route can be set up directly, but it is difficult for the system operator to directly participate in the route of the EV. In this paper, a method is proposed to indirectly change the route of the EV by changing the charging cost through real-time dynamic pricing, in order to prevent risks in the system operation due to voltage fluctuations in the system. With dynamic pricing, the voltage of the system is kept within a stable range, and the EV user sets the route with an economic benefit. The proposed scheme is verified through Dijkstra&rsquo s algorithm and a control strategy via a simulation model using MATLAB. Document type: Articl

(E)-2,2′-[3-(2-Nitro­phen­yl)prop-2-ene-1,1-di­yl]bis­(3-hy­droxy-5,5-dimethyl­cyclo­hex-2-en-1-one)

In the title compound, C25H29NO6, each of the cyclo­hexenone rings adopts a half-chair conformation. Each of the pairs of hy­droxy and carbonyl O atoms are oriented to allow for the formation of intra­molecular O—H⋯O hydrogen bonds, which are typical of xanthene derivatives. The nitro group is rotationally disordered over two orientations in a 0.544 (6):0.456 (6) ratio. In the crystal, weak inter­molecualr C—H⋯O hydrogen bonds link mol­ecules into layers parallel to the ab plane

Prestack depth migration using straight ray technique(SRT)

Kirchhoff prestack depth migration requires an elaborate book-keeping effort and a massive IO process to construct Kirchhoff hyperbolas. In order to avoid the complexity of the programming code and the massive IO process, we propose a straight ray technique (SRT) for traveltimi calculations in Kirchhoff migration. Since all the rays are straight in. polar coordinates for the 2D velocity model,or in sphericalc oordinatesf or the 3D velocity model, traveltimesc an be simply computed along a straight ray for a given source-receiver configuration,without suffering from shadow zones and caustics, and used directly for building Kirchhoff hyperbolas. In this way, we clrcumvent the substantial IO process required for reading traveltimes on a disk and save computationals torage.N umerical examplesd emonstrateth at SRT computest raveltimesi ntermediate between first-arrival traveltimes and the most energetic arrival traveltimes, resulting in better images than the first arrival traveltimes for the 2D IFP Marmousi data. With the implementation of SRT for 2D Kirchhoff migration, we successfully extend our SRT to 3D Kirchhoff misration for the SECiEAGE salr dome data.This work was financially supported by the National Laboratory Project of the Ministry of Science and Technology, Brain Korea 21 Project of the Ministry of Education, grant No. R05-2000-00003 from the Basic Research Program of the Korea Science & Engineering Foundation, and grant No. PM10300 from the Korea Ocean Research & Development Institute

3-Hy­droxy-2-[(2E)-1-(2-hy­droxy-6-oxocyclo­hex-1-en-1-yl)-3-(2-meth­oxy­phen­yl)prop-2-en-1-yl]cyclo­hex-2-en-1-one

In the title compound, C22H24O5, each of the cyclo­hexenone rings adopts a half-chair conformation. The hy­droxy and carbonyl O atoms face each other and are orientated to allow for the formation of the two intra­molecular O—H⋯O hydrogen bonds which are typical of xanthene derivatives. In the crystal, weak inter­molecular C—H⋯O hydrogen bonds link mol­ecules into layers parallel to the ab plane

A role of DNA-dependent protein kinase for the activation of AMP-activated protein kinase in response to glucose deprivation

AbstractThe catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) plays an essential role in double-strand break repair by initially recognizing and binding to DNA breaks. Here, we show that DNA-PKcs interacts with the regulatory γ1 subunit of AMP-activated protein kinase (AMPK), a heterotrimeric enzyme that has been proposed to function as a “fuel gauge” to monitor changes in the energy status of cells and is controlled by the upstream kinases LKB1 and Ca2+/calmodulin-dependent kinase kinase (CaMKK). In co-immunoprecipitation analyses, DNA-PKcs and AMPKγ1 interacted physically in DNA-PKcs-proficient M059K cells but not in DNA-PKcs-deficient M059J cells. Glucose deprivation-stimulated phosphorylation of AMPKα on Thr172 and of acetyl-CoA carboxylase (ACC), a downstream target of AMPK, is substantially reduced in M059J cells compared with M059K cells. The inhibition or down-regulation of DNA-PKcs by the DNA-PKcs inhibitors, wortmannin and Nu7441, or by DNA-PKcs siRNA caused a marked reduction in AMPK phosphorylation, AMPK activity, and ACC phosphorylation in response to glucose depletion in M059K, WI38, and IMR90 cells. In addition, DNA–DNA-PKcs−/− mouse embryonic fibroblasts (MEFs) exhibited decreased AMPK activation in response to glucose-free conditions. Furthermore, the knockdown of DNA-PKcs led to the suppression of AMPK (Thr172) phosphorylation in LKB1-deficient HeLa cells under glucose deprivation. Taken together, these findings support the positive regulation of AMPK activation by DNA-PKcs under glucose-deprived conditions in mammalian cells