10,005 research outputs found
Do the suburbs exist? Discovering complexity and specificity in suburban built form
In human geography cities are routinely acknowledged as complex and dynamic built environments. This description is rarely extended to the suburbs, which are generally regarded as epiphenomena of the urbs and therefore of little intrinsic theoretical interest in themselves. This article presents a detailed critique of this widely held assumption by showing how the idea of 'the suburban' as an essentially non-problematic domain has been perpetuated from a range of contrasting disciplinary perspectives, including those that directly address suburban subject matter. The result has been that attempts to articulate the complex social possibilities of suburban space are easily caught between theories of urbanisation that are insensitive to suburban specificity and competing representations of the suburb that rarely move beyond the culturally specific to consider their generic significance. This article proposes that the development of a distinctively suburban theory would help to undermine one-dimensional approaches to the built environment by focusing on the relationship between social organisation and the dynamics of emergent built form
A multi-disciplinary perspective on the built environment: Space Syntax and cartography – the communication challenge
8-11 June 2009
A warped kernel improving robustness in Bayesian optimization via random embeddings
This works extends the Random Embedding Bayesian Optimization approach by
integrating a warping of the high dimensional subspace within the covariance
kernel. The proposed warping, that relies on elementary geometric
considerations, allows mitigating the drawbacks of the high extrinsic
dimensionality while avoiding the algorithm to evaluate points giving redundant
information. It also alleviates constraints on bound selection for the embedded
domain, thus improving the robustness, as illustrated with a test case with 25
variables and intrinsic dimension 6
Flood management consideration in sustainability appraisal and strategic environmental assessment in England and Scotland
The impact of flood events in the UK has drawn attention to limitations associated with traditional flood defence regimes. In recognition of this there has been a significant level of advocacy for a systems based approach which assumes a greater role for spatial planning. This paper considers the extent to which strategic assessment contributes toward the consideration of flooding within spatial planning. The paper draws on four cases from England and Scotland. Specific attention is given to the nature of flood management approaches considered in assessment and the recommendations presented. The research indicates that assessment practice is dominated by probabilistic calculations of flood risk and typically replicates national policy and guidance on flood management. It is argued that there exists potential for assessment to foster more nuanced and tailored consideration of flood management by including multiple perspectives, such as management of the whole system, risk and vulnerability, resilience and adaptation
Underwater near infrared spectroscopy (uNIRS) can measure training adaptations in adolescent swimmers
The development of an underwater near-infrared spectroscopy (uNIRS) device has enabled previously unattainable measurements of peripheral muscle hemodynamics and oxygenation to be taken within the natural aquatic environment. The purposes of this study were (i) to trial the use of uNIRS, in a real world training study, and (ii) to monitor the effects of a swim training program upon muscle oxygenation status in short distance swimming. 14 junior club level swimmers completed a repeated swim sprint test before and after an eight week endurance training program. A waterproof, portable NIRS device was attached to the vastus lateralis. uNIRS successfully measured changes in muscle oxygenation and blood volume in all individuals; rapid sub-second time resolution of the device was able to demonstrate muscle oxygenation changes during the characteristic swim movements. Post training heart rate recovery and swim performance time were significantly improved. uNIRS data also showed significant changes. A larger rise in deoxyhemoglobin during individual sprints suggested training induced an increase in muscle oxygen extraction; a faster recovery time for muscle oxygenation suggested positive training induced changes and significant changes in muscle blood volume also occur. As a strong correlation was seen between an increased reoxygenation rate and an improved swim performance time, these findings support the use of uNIRS as a new performance analysis tool in swimming
Congenital Cytomegalovirus Infection: Management Update
Purpose of review
Until recently, management options in congenital cytomegalovirus (cCMV) infection have been either
conservative or termination of pregnancy. However, medical therapies aimed at reducing the risk of
infection and/or its severity have recently been investigated.
Recent findings
In a phase 2 open label, nonrandomized trial, valaciclovir (ValACV) was given to women carrying a
CMV-infected fetus. ValACV was associated with a greater proportion of asymptomatic neonates when
compared with a historical cohort (82 vs. 43%). However, the study design and the small number of
treated women limit its applicability. Even though initial observational data suggested that hyperimmune
globulin (HIG) therapy in pregnancy was associated with a significantly lower risk of cCMV, its efficacy
has not been borne out in a subsequent phase 2 randomized, placebo controlled, double-blind study
[cCMV 30% in the HIG group, 44% in the placebo group (
P=0.13)]. Furthermore, 11% of fetuses in the
HIG group had transient or permanent abnormalities, compared with 16% in the placebo group.
Summary
ValACV might have a promising role in the antenatal treatment of cCMV infection, but definitive
recommendations require further research. The use of HIG should currently be limited to the research
setting.
Video abstract http://links.lww.com/COID/A18
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