Social Investment. As a new charity finance tool: using both head and heart

Presenting associations between individual amino acid residues and EULAR response. (DOCX 23 kb

Number of events and Incidence rates of first NL diagnosis during study period in AS patients (n = 8,572) compared to general population comparators (n = 39,639), overall and stratified by status on NL diagnosis prior to study entry.

<p>GPC; general population comparators.</p><p>py; person-years. Person years defined as starting at the date of entry into study (time of AS diagnosis, earliest Jan 1^st 2001) until first of death, emigration, nephrolithiasis diagnosis or end of study (Dec 31^st 2009).</p><p>IQR; interquartile range, IR; incidence rate, CI; confidence interval.</p><p>Number of events and Incidence rates of first NL diagnosis during study period in AS patients (n = 8,572) compared to general population comparators (n = 39,639), overall and stratified by status on NL diagnosis prior to study entry.</p

Flow of AS patients and general population comparators (GPC) prior to and during follow-up, until end of study period.

<p>Flow of AS patients and general population comparators (GPC) prior to and during follow-up, until end of study period.</p

Baseline characteristics of AS cohort and matched general population comparator subjects at study entry.

<p>Baseline characteristics of AS cohort and matched general population comparator subjects at study entry.</p

HRs (95%CI) for all covariates included in initial multivariate Cox regression model.

<p>HRs (95%CI) for all covariates included in initial multivariate Cox regression model.</p

Incidence Rates (95%CI) of NL diagnosis in AS patients and general population comparators (GPC).

<p>Incidence Rates (95%CI) of NL diagnosis in AS patients and general population comparators (GPC).</p

Additional file 2: of Perinatal characteristics, older siblings, and risk of ankylosing spondylitis: a case–control study based on national registers

Regression analyses stratified by sex and birth year. (DOCX 20 kb

Prevalence of Periodontitis in Patients with Established Rheumatoid Arthritis: A Swedish Population Based Case-Control Study

<div><p>Introduction</p><p>The possible hypothesis of a link between periodontitis and rheumatoid arthritis (RA), specifically anti-citrullinated protein antibody (ACPA) positive RA, prompted us to investigate the prevalence of periodontitis in the Swedish Epidemiological Investigation of RA (EIRA), a well-characterised population-based RA case-control cohort.</p><p>Methods</p><p>Periodontal status of 2,740 RA cases and 3,942 matched controls was retrieved through linking EIRA with the National Dental Health Registry (DHR), where dental diagnostic- and treatment codes on the adult Swedish population have been registered. Dental records from 100 cases and controls were reviewed to validate the periodontal diagnostic codes in DHR.</p><p>Results</p><p>The reviewed dental records confirmed 90% of the periodontitis diagnoses in DHR among RA cases, and 88% among controls. We found the positive predictive value of periodontitis diagnoses in the DHR to be 89% (95% CI 78 to 95%) with a sensitivity of 77% (95% CI: 65 to 86%). In total, 86% of EIRA participants were identified in DHR. The risk for periodontitis increased by age and current smoking status in both cases as well as controls. No significant differences in prevalence of periodontal disease in terms of gingivitis, periodontitis, peri-implantitis or increased risk for periodontitis or peri-implantitis were observed between RA cases and controls. In addition, there was no difference on the basis of seropositivity, ACPA or rheumatoid factor (RF), among patients with RA.</p><p>Conclusions</p><p>Our data verify that smoking and ageing are risk factors for periodontitis, both in RA and controls. We found no evidence of an increased prevalence of periodontitis in patients with established RA compared to healthy controls, and no differences based on ACPA or RF status among RA subjects.</p></div

EIRA RA cases and controls with periodontal treatment codes, in relation to ACPA status.

<p>EIRA RA cases and controls with periodontal treatment codes, in relation to ACPA status.</p

Study design.

<p>Schematic overview of the study, including linkage of EIRA (Epidemiological Investigation of Rheumatoid Arthritis) with DHR (Dental Health Registry) and the validation of the diagnostic codes from DHR using dental records.</p