Value of 18F-PSMA PET/MRI for early diagnosis of recurrence and metastasis in prostate cancer patients after radical prostatectomy

Objective: To investigate the value and significance of 18F-prostate-specific membrane antigen (18F-PSMA)-1007 PET/MR for early diagnosis of recurrence and metastasis in prostate cancer patients after radical prostatectomy (RP). Methods: A total of 143 patients with prostate cancer after radical prostatectomy were enrolled during June 2019 to January 2022 in Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. All the patients underwent 18F-PSMA-1007 PET/MR imaging within 12 to 60 months after surgery. According to the serum prostate-specific antigen (PSA) levels, patients were divided into 5 groups（PSA≤0.2 ng/mL, 0.2 ng/mL<PSA≤0.5 ng/mL, 0.5 ng/mL<PSA≤4.0 ng/mL, 4.0 ng/mL<PSA<10.0 ng/mL and PSA≥10.0 ng/mL). The detection rates of recurrence or metastasis were compared between different groups. Results: The detection rates of 18F-PSMA-1007 PET/MR for recurrence or metastasis in PSA≤0.2 ng/mL, 0.2 ng/mL<PSA≤0.5 ng/mL, 0.5 ng/mL< PSA ≤ 4.0 ng/mL, 4.0 ng/mL<PSA<10.0 ng/mL and PSA ≥ 10.0 ng/mL groups were 25.00% (6/24)，70.00% (7/10)，66.67% (16/24)，74.07% (20/27) and 94.83% (55/58) respectively, and bilateral comparison between groups revealed that difference in detection rate was statistically significant (P<0.01 or P<0.05). In terms of treatment，34 patients (27.64%) changed their pre-examination treatment regimen based on the results of 18F-PSMA-1007 PET/MR imaging. Conclusions: It reveals that prostate patients with detected recurrence or metastasis account for 25% of those with normal PSA level.The detection rate increases with the increase of PSA levels. It suggests that 18F-PSMA PET/MR can detect recurrence and metastasis in the early stage, which can effectively guide the formulation of treatment plans

Figure 8 from: Liu J, Huang Z, Xu X, Yin H (2020) Redescription of types of three species of Leptonetidae Simon, 1890 from China (Arachnida, Araneae). ZooKeys 1000: 1-17. https://doi.org/10.3897/zookeys.1000.57660

Figure 8 Leptonetela unispinosa (Yin et al., 1984), comb. nov., holotype male A palpal bulb, ventral view B chelicera, retrolateral view C palp, prolateral view D palp, retrolateral view. Abbreviations: Co, conductor; E, embolus; MA, median apophysis; PL, prolateral lobe; TS, tibial spur

Research on Aerodynamic Optimization Method of Multistage Axial Compressor under Multiple Working Conditions Based on Phased Parameterization Strategy

Multistage axial compressor is the key component of aeroengine and gas turbine to realize energy conversion. In order to avoid the “curse of dimensionality” problem in the global optimization process of AL-31F four-stage low-pressure compressor under multiple working conditions, an optimization method based on phased parameterization strategy is proposed. The method uses the idea of “exploration before exploitation” for reference and divides the optimization process into two phases. In the first phase, the traditional parametric modification method based on stacking line is adopted; in the second phase, the full-blade surface parametric modification method with significant low-dimensional characteristics is adopted. Based on the improved artificial bee colony algorithm, a multitask concurrent optimization system is built on the supercomputing platform, and the engineering optimization solution is obtained within 91 hours. The optimization results are as follows: under the condition of meeting the constraints, the adiabatic efficiency is increased by 0.3% and the surge margin is 4.0% at the design speed; the adiabatic efficiency is increased by 0.8% and the surge margin is 2.3% at the off-design speed. These results verify the usefulness and reliability of the optimization method in the field of aerodynamic optimization of a multistage axial flow compressor

New species of the pirate spider genus Mimetus Hentz, 1832 from China with a cladistic hypothesis on their phylogenetic placement (Araneae, Mimetidae)

Liu, Jinxin, Xu, Xiang, Hormiga, Gustavo, Yin, Haiqiang (2021): New species of the pirate spider genus Mimetus Hentz, 1832 from China with a cladistic hypothesis on their phylogenetic placement (Araneae, Mimetidae). Zootaxa 5020 (1): 1-30, DOI: https://doi.org/10.11646/zootaxa.5020.1.

Aerodynamic Optimization of Transonic Rotor Using Radial Basis Function Based Deformation and Data-Driven Differential Evolution Optimizer

The complicated flow conditions and massive design parameters bring two main difficulties to the aerodynamic optimization of axial compressors: expensive evaluations and numerous optimization variables. To address these challenges, this paper establishes a novel fast aerodynamic optimization platform for axial compressors, consisting of a radial basic function (RBF)-based blade parameterization method, a data-driven differential evolution optimizer, and a computational fluid dynamic (CFD) solver. As a versatile interpolation method, RBF is used as the shape parameterization and deformation technique to reduce optimization variables. Aiming to acquire competitive solutions in limited steps, a data-driven evolution optimizer is developed, named the pre-screen surrogate model assistant differential evolution (pre-SADE) optimizer. Different from most surrogate model-assisted evolutionary algorithms, surrogate models in pre-SADE are used to screen the samples, rather than directly estimate them, in each generation to reduce expensive evaluations. The polynomial regression model, Kriging model, and RBF model are integrated in the surrogate model to improve the accuracy. To further save optimization time, the optimizer also integrates parallel task management programs. The aerodynamic optimization of a transonic rotor (NASA Rotor 37) is performed as the validation of the platform. A differential evolution (DE) optimizer and another surrogate model-assisted algorithm, committee-based active learning for surrogate model assisted particle swarm optimization (CAL-SAPSO), are introduced for the comparison runs. After optimization, the adiabatic efficiency, total pressure ratio, and surge margin are, respectively, increased by 1.47%, 1.0%, and 0.79% compared to the initial rotor. In the same limited steps, pre-SADE gets a 0.57% and 0.51% higher rotor adiabatic efficiency than DE and CAL-SAPSO, respectively. With the help of parallel techniques, pre-SADE and DE save half the optimization time compared to CAL-SAPSO. The results verify the effectiveness and the rapidity of the fast aerodynamic optimization platform

Redescription of types of three species of Leptonetidae Simon, 1890 from China (Arachnida, Araneae)

Three species of the genus Leptoneta Simon, 1872 deposited at Hunan Normal University, Changsha, China, are examined and redescribed. Two species are transferred from Leptoneta Simon, 1872 to Leptonetela Kratochvíl, 1978, and the following new combinations are proposed: Leptonetela trispinosa (Yin, Wang & Wang, 1984), comb. nov. (♀♂), and Leptonetela unispinosa (Yin, Wang & Wang, 1984), comb. nov. (♂). The generic placement of Leptoneta monodactyla Yin, Wang & Wang, 1984 is maintained. Detailed descriptions, illustrations, and a distribution map for all three species are provided

The Transitional Wettability on Bamboo-Leaf-like Hierarchical-Structured Si Surface Fabricated by Microgrinding

Stabilizing the hydrophobic wetting state on a surface is essential in heat transfer and microfluidics. However, most hydrophobic surfaces of Si are primarily achieved through microtexturing with subsequent coating or modification of low surface energy materials. The coatings make the hydrophobic surface unstable and impractical in many industrial applications. In this work, the Si chips’ wettability transitions are yielded from the original hydrophilic state to a stable transitional hydrophobic state by texturing bamboo-leaf-like hierarchical structures (BLHSs) through a diamond grinding wheel with one-step forming. Experiments showed that the contact angles (CAs) on the BLHS surfaces increased to 97° and only reduced by 2% after droplet impacts. This is unmatched by the current texturing surface without modification. Moreover, the droplets can be split up and transferred by the BLHS surfaces with their 100% mass. When the BLHS surfaces are modified by the low surface energy materials’ coating, the hydrophobic BLHS surfaces are upgraded to be superhydrophobic (CA > 135°). More interestingly, the droplet can be completely self-sucked into a hollow micro-tube within 0.1 s without applying external forces. A new wetting model for BLHS surfaces based on the fractal theory is determined by comparing simulated values with the measured static contact angle of the droplets. The successful preparation of the bamboo-leaf-like Si confirmed that transitional wettability surfaces could be achieved by the micromachining of grinding on the hard and brittle materials. Additionally, this may expand the application potential of the key semiconductor material of Si