A new abietane diterpenoid from the roots of <i>Tripterygium regelii</i>

<p>A new abietane diterpenoid, tripterregeline A (<b>1</b>), together with six known diterpenoids (<b>2</b>–<b>7</b>), were isolated from the roots of <i>Tripterygium regelii</i>. The structure of <b>1</b> was elucidated by extensive spectroscopic methods and the known compounds were identified by comparison with data reported in the literature. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 <i>in vitro</i>. Compounds <b>1</b>–<b>7</b> showed significant inhibitory effects against various human cancer cell lines with IC₅₀ values ranging from 0.58 to 21.06 μM.</p

Chemical constituents from <i>Piper wallichii</i>

<div><p>Fifteen known compounds including four triterpenoids (<b>1</b>–<b>4</b>), one sterol (<b>5</b>), one diketopiperazine alkaloid (<b>6</b>) and nine phenolics (<b>7</b>–<b>15</b>) were isolated from the stems of <i>Piper wallichii</i>. Their structures were elucidated by means of spectroscopic analysis, and acidic hydrolysis in case of the 2-oxo-3β,19α,23-trihydroxyurs-12-en-28-oic acid β-D-glucopyranosyl ester (<b>1</b>). The structure of compound <b>1</b> was fully assigned by 1D and 2D NMR experiments for the first time. All isolates were tested for their antibacterial, antifungal, anti-inflammatory and antiplatelet aggregation bioactivities.</p></div