20 research outputs found
Bright solitons in a spin-orbit-coupled dipolar Bose-Einstein condensate trapped within a double-lattice
By effectively controlling the dipole-dipole interaction, we investigate the
characteristics of the ground state of bright solitons in a spin-orbit coupled
dipolar Bose-Einstein condensate. The dipolar atoms are trapped within a
double-lattice which consists of a linear and a nonlinear lattice. We derive
the motion equations of the different spin components, taking the controlling
mechanisms of the diolpe-dipole interaction into account. An analytical
expression of dipole-dipole interaction is derived. By adjusting the dipole
polarization angle, the dipole interaction can be adjusted from attraction to
repulsion. On this basis, we study the generation and manipulation of the
bright solitons using both the analytical variational method and numerical
imaginary time evolution. The stability of the bright solitons is also analyzed
and we map out the stability phase diagram. By adjusting the long-range
dipole-dipole interaction, one can achieve manipulation of bright solitons in
all aspects, including the existence, width, nodes, and stability. Considering
the complexity of our system, our results will have enormous potential
applications in quantum simulation of complex systems
China's New Social Security System in Making: Problems and Prospects
China’s welfare regime has been historically characterized by its structural
arrangement, distinguishing itself from that of many other countries. The major difference
lies in the efforts made by the Chinese government to build up a social safety-net
to be compatible not merely with societal needs but more critically with its unique
political structure to ensure its legitimacy and stability are unchallenged. We argue that
while ensuring political stability continues to remain as a policy priority, China’s current
welfare restructuring is being confronted by freed-up market forces that make it
more difficult to acheive a delicate balance between where the needs are and how
resources are allocated
Comparing the clinical efficacy of three surgical methods for cesarean scar pregnancy
Abstract Background We aimed to compare the clinical efficacy of three surgical methods in the treatment of various types of cesarean scar pregnancy (CSP). Methods Herein, 314 cases of CSP were treated in the department of Obstetrics and Gynecology of the First Affiliated Hospital of Gannan Medical University between June 2017 and June 2020. The patients were divided into three groups based on the treatment received: group A (n = 146; curettage by pituitrin combined with ultrasonic monitoring and hysteroscopy-guided surgery), group B [n = 90; curettage after methotrexate (MTX) injection into the local gestational sac], and group C (n = 78; laparoscopic, transvaginal, and transabdominal cesarean scar resection). These groups were divided into three subgroups (type I, type II, and type III) according to the CSP type of the patients. Results The intraoperative blood loss, length of hospital stay, hospitalization cost, menstrual recovery time, and serum β-HCG normalization time were lower in groups A than in groups B or C with type I, II and III CSP (P < 0.05). Operative efficiency and Successful second pregnancy rate were higher in groups A than in groups B or C with type I and II CSP (P < 0.05). But in type III CSP, the complications were more serious in group A than group C. Conclusions Curettage by pituitrin combined with ultrasonic monitoring and hysteroscopy-guided surgery is an effective and relatively safe treatment for patients with type I and II CSP. Laparoscopic surgery is more suitable for type III CSP
The Role of Interleukin-17 in Lung Cancer
Tumour-associated inflammation is a hallmark of malignant carcinomas, and lung cancer is a typical inflammation-associated carcinoma. Interleukin-17 (IL-17) is an important inflammatory cytokine that plays an important role in chronic inflammatory and autoimmune diseases and in inflammation-associated tumours. Numerous studies have shown that IL-17 directly or indirectly promotes tumour angiogenesis and cell proliferation and that it inhibits apoptosis via the activation of inflammatory signalling pathways. Therefore, IL-17 contributes to the metastasis and progression of lung cancer. Research advances with respect to the role of IL-17 in lung cancer will be presented as a review in this paper
Ischemic Neurons Recruit Natural Killer Cells That Accelerate Brain Infarction
Brain ischemia and reperfusion activate the immune system. The abrupt development of brain ischemic lesions suggests that innate immune cells may shape the outcome of stroke. Natural killer (NK) cells are innate lymphocytes that can be swiftly mobilized during the earliest phases of immune responses, but their role during stroke remains unknown. Herein, we found that NK cells infiltrated the ischemic lesions of the human brain. In a mouse model of cerebral ischemia, ischemic neuron-derived fractalkine recruited NK cells, which subsequently determined the size of brain lesions in a T and B cell-independent manner. NK cell-mediated exacerbation of brain infarction occurred rapidly after ischemia via the disruption of NK cell tolerance, augmenting local inflammation and neuronal hyperactivity. Therefore, NK cells catalyzed neuronal death in the ischemic brain
The ACE2/Angiotensin-(1–7)/Mas Receptor Axis: Pleiotropic Roles in Cancer
Cancer remains one of the most common causes of death and disability and represents a major economic burden in industrialized nations. The renin-angiotensin system (RAS) has been well-recognized as one of the most important regulators of both normal and pathological physiological processes in the brain, kidney, heart, and blood vessels. The activation of the angiotensin-converting enzyme 2/angiotensin-(1–7)/mitochondrial assembly receptor [ACE2/Ang-(1–7)/MasR] axis, which is one component of the RAS, has recently been identified as a critical component of pulmonary systems, gastric mucosa, and cancer. However, the ability of the ACE2/Ang-(1–7)/MasR axis to suppress or promote cancer has not been fully elucidated. In this review, we focus on recent experimental and clinical studies investigating the basic properties, roles, and mechanisms of ACE2, Ang-(1–7), and the MasR, as well as the axis pathway, to provide insights into possible therapeutic strategies for treating cancer that target the ACE2/Ang-(1–7)/MasR axis
Biodegradable Hyperbranched Polyglycerol with Ester Linkages for Drug Delivery
Biodegradable hyperbranched polyglycerols (dHPGs) were
synthesized
through oxyanionic initiating hybrid polymerization of glycerol and
glycidyl methacrylate. Due to the introduction of ester linkages into
the hyperbranched polyglycerol backbone, dHPGs showed good biodegradability
and low cytotoxicity. Benefiting from the existence of terminal hydroxyls
and methacryloyl groups, both the anticancer drug methotrexate (MTX)
and fluorescent probe Rhodamine-123 could be conjugated onto the surface
of dHPGs easily. The resultant MTX-conjugated polymers (dHPG-MTXs)
exhibited an amphiphilic character, resulting in the formation of
micelles in an aqueous solution. The release of MTX from micelles
was significantly faster at mildly acidic pH of 5.0 compared to physiological
pH of 7.4. dHPG-MTX micelles could be efficiently internalized by
cancer cells. MTT assay against cancer cells showed dHPG-MTXs micelles
had high anticancer efficacy. On the basis of their good biodegradability
and low cytotoxicity, dHPGs provide an opportunity to design excellent
drug delivery systems