Cavity-enhanced and spatial-multimode spin-wave-photon quantum interface

Practical realizations of quantum repeaters require quantum memory simultaneously providing high retrieval efficiency, long lifetime and multimode storages. So far, the combination of high retrieval efficiency and spatially multiplexed storages into a single memory remains challenging. Here, we set up a ring cavity that supports an array including 6 TEM00 modes and then demonstrated cavity enhanced and spatially multiplexed spin wave photon quantum interface (QI). The cavity arrangement is according to Fermat' optical theorem, which enables the six modes to experience the same optical length per round trip. Each mode includesn horizontal and vertical polarizations. Via DLCZ process in a cold atomic ensemble, we create non classically correlated pairs of spin waves and Stokes photons in the 12 modes. The retrieved fields from the multiplexed SWs are enhanced by the cavity and the average intrinsic retrieval efficiency reaches 70% at zero delay. The storage time for the case that cross-correlation function of the multiplexed QI is beyond 2 reaches 0.6ms

Integrated single-cell and bulk characterization of cuproptosis key regulator PDHB and association with tumor microenvironment infiltration in clear cell renal cell carcinoma

BackgroundRenal clear cell carcinoma (ccRCC) is one of the most prevalent cancers worldwide. Accumulating evidence revealed that copper-induced cell death played a vital role in various tumors. However, the underlying mechanism of cuproptosis with molecular heterogeneity and tumor microenvironment (TME) in ccRCC remains to be elucidated. The present study aimed to discover the biological function of cuproptosis regulators with the potential to guide clinical therapy.MethodsUsing Single-cell RNA-seq, bulk transcriptome and other multi-omics datasets, we identify essential cuproptosis-related hub gene PDHB for further study. The dysregulation of PDHB in ccRCC was characterized, together with survival outcomes, pathway enrichment and immune infiltration among tumor microenvironments. The functional significance and clinical association of PDHB was validated with loss of function experiments and surgical removal specimens.ResultsPDHB mRNA and protein expression level was significantly downregulated in ccRCC tissues compared with normal and paired normal tissues. Clinicopathological parameters and tissue microarray (TMA) indicated that PDHB was identified as a prognostic factor for survival outcomes among ccRCC patients. Additionally, low PDHB was negatively correlated with Treg cells, indicating an immunosuppressive microenvironment. Mechanistically, knockdown PDHB appeared to promote the RCC cells proliferation, migration, and invasion potentials. Subsequent studies showed that copper-induced cell death activation could overcome sunitinib resistance in RCC cells.ConclusionThis research illustrated a cuproptosis-related hub gene PDHB which could serve as a potential prognostic marker and provide therapeutic benefits for clinical treatment of ccRCC patients

Recognizing emotions induced by wearable haptic vibration using noninvasive electroencephalogram

The integration of haptic technology into affective computing has led to a new field known as affective haptics. Nonetheless, the mechanism underlying the interaction between haptics and emotions remains unclear. In this paper, we proposed a novel haptic pattern with adaptive vibration intensity and rhythm according to the volume, and applied it into the emotional experiment paradigm. To verify its superiority, the proposed haptic pattern was compared with an existing haptic pattern by combining them with conventional visual–auditory stimuli to induce emotions (joy, sadness, fear, and neutral), and the subjects’ EEG signals were collected simultaneously. The features of power spectral density (PSD), differential entropy (DE), differential asymmetry (DASM), and differential caudality (DCAU) were extracted, and the support vector machine (SVM) was utilized to recognize four target emotions. The results demonstrated that haptic stimuli enhanced the activity of the lateral temporal and prefrontal areas of the emotion-related brain regions. Moreover, the classification accuracy of the existing constant haptic pattern and the proposed adaptive haptic pattern increased by 7.71 and 8.60%, respectively. These findings indicate that flexible and varied haptic patterns can enhance immersion and fully stimulate target emotions, which are of great importance for wearable haptic interfaces and emotion communication through haptics

Role of melatonin in enhancing arbuscular mycorrhizal symbiosis and mitigating cold stress in perennial ryegrass (Lolium perenne L.)

Melatonin is a biomolecule that affects plant development and is involved in protecting plants from environmental stress. However, the mechanisms of melatonin’s impact on arbuscular mycorrhizal (AM) symbiosis and cold tolerance in plants are still unclear. In this research, AM fungi inoculation and exogenous melatonin (MT) were applied to perennial ryegrass (Lolium perenne L.) seedlings alone or in combination to investigate their effect on cold tolerance. The study was conducted in two parts. The initial trial examined two variables, AM inoculation, and cold stress, to investigate the involvement of the AM fungus Rhizophagus irregularis in endogenous melatonin accumulation and the transcriptional levels of its synthesis genes in the root system of perennial ryegrass under cold stress. The subsequent trial was designed as a three-factor analysis, encompassing AM inoculation, cold stress, and melatonin application, to explore the effects of exogenous melatonin application on plant growth, AM symbiosis, antioxidant activity, and protective molecules in perennial ryegrass subjected to cold stress. The results of the study showed that compared to non-mycorrhizal (NM) plants, cold stress promoted an increase in the accumulation of melatonin in the AM-colonized counterparts. Acetylserotonin methyltransferase (ASMT) catalyzed the final enzymatic reaction in melatonin production. Melatonin accumulation was associated with the level of expression of the genes, LpASMT1 and LpASMT3. Treatment with melatonin can improve the colonization of AM fungi in plants. Simultaneous utilization of AM inoculation and melatonin treatment enhanced the growth, antioxidant activity, and phenylalanine ammonia-lyase (PAL) activity, while simultaneously reducing polyphenol oxidase (PPO) activity and altering osmotic regulation in the roots. These effects are expected to aid in the mitigation of cold stress in Lolium perenne. Overall, melatonin treatment would help Lolium perenne to improve growth by promoting AM symbiosis, improving the accumulation of protective molecules, and triggering in antioxidant activity under cold stress

The optimization for the inequalities of power means

Let be the th power mean of a sequence of positive real numbers, where , and . In this paper, we will state the important background and meaning of the inequality ; a necessary and sufficient condition and another interesting sufficient condition that the foregoing inequality holds are obtained; an open problem posed by Wang et al. in 2004 is solved and generalized; a rulable criterion of the semipositivity of homogeneous symmetrical polynomial is also obtained. Our methods used are the procedure of descending dimension and theory of majorization; and apply techniques of mathematical analysis and permanents in algebra.</p

Social Company Disrupts Fear Memory Renewal: Evidence From Two Rodent Studies

Renewal of fear outside treatment context is a challenge for behavioral therapies. Prior studies suggest a social buffering effect that fear response is attenuated in the presence of social company. However, few studies have examined the role of social company in reducing fear renewal. Here, we used a Pavlovian fear conditioning procedure including acquisition, extinction and test stages to examine social buffering effect on fear memory renewal in male rats. The test context was manipulated to be either different from the extinction one in ABC model, or same as that in ACC model. All conditioned subjects underwent extinction individually in Experiment 1 but with a partner in Experiment 2. In test, both experiments manipulated social company (alone vs. accompanied) and context (ABC vs. ACC). Experiment 1 showed more freezing in ABC than in ACC model during the test-alone condition, indicating a fear renewal effect which, however, was absent during the test-accompanied condition. Also, accompanied subjects showed less freezing compared to alone subjects in the ABC model. In Experiment 2, animals showed a similar freezing in ABC and ACC models despite being tested alone, implying that social company offered at extinction disrupted fear renewal. Again, we observed reduced freezing in accompanied relative to alone subjects in the test. These results suggest that social company is effective in disrupting fear renewal after leaving treatment context