zip file containing 6 data sets

This zip file contains the following data: (i) "oocyst and egg.txt" contains data used to analyse the oocyst rate and intensity as well as egg incidence, (ii) "survival 7 dp.txti" was used ti analyse mosquito survival until 7 day-post infection, (iii) "sporozoite index.txt" was used to analyse sporozoite rate at 14 day post-infection, (iv) "survival 14 dpi.txt" was used to analyse mosquito survival until 14 days post-infection, (v) "sporozoite temporal dynamic.txt" was used to analyse the parasite extrinsic incubation period, and (vi) "longevity.txt" was used to analyse the effect of plant treatment on the longevity of infected and uninfected control mosquitoes

Study profile.

<p>Study profile.</p

Trends of the molecular markers according to the parasite density.

<p>Trends of the molecular markers according to the parasite density.</p

Baseline characteristics by presence or not of symptoms.

<p>Baseline characteristics by presence or not of symptoms.</p

Prevalence of the <i>dhfr</i> and <i>dhps</i> point mutations associated with SP resistance.

<p>Prevalence of the <i>dhfr</i> and <i>dhps</i> point mutations associated with SP resistance.</p

Effect of sugar treatment on the sporozoite index and EIP.

<p>(a) Sporozoite index (± 95% CI), expressed as the proportion of mosquitoes exposed to an infectious blood meal and having disseminated sporozoites in their head/thoraces, over 2 replicates and using a total of 4 gametocyte carriers. Numbers in brackets indicate, for each sugar treatment, the total number of mosquitoes analyzed with PCR on 14 days post infection (dpi). Different letters above the bars denote statistically significant differences based on multiple pair-wise post-hoc tests. (b) Survivorship of malaria-exposed mosquitoes for each sugar treatment over 2 replicates, and using a total of 4 gametocyte carriers. Survival was recorded twice a day from 1 to 14 dpi. (c) Sporozoite index (± 95% CI) over time and using a total of 2 gametocyte carriers. *p<0.05; **p < 0.01, NS: non-significant difference between sugar treatment</p

Additional file 1: of Ex vivo anti-malarial drug susceptibility of Plasmodium falciparum isolates from pregnant women in an area of highly seasonal transmission in Burkina Faso

Figure S1. Scatter of the IC50 values with geometric mean and the resistance cutoff (where available) of each drug. In order to better visualize and understand the data, a figure showing the scatter of the IC50 values with geometric mean and the resistance cutoff (where available) of each drug is proposed

Effect of sugar treatment on the early development of <i>P</i>. <i>falciparum</i>, and on the survival and fecundity of malaria-exposed <i>Anopheles coluzzii</i>.

<p>(a) Infection rate (± 95% CI), expressed as the proportion of mosquitoes exposed to an infectious blood meal and harboring at least one oocyst in their midgut, over 4 replicates and using a total of 7 gametocyte carriers. Numbers in brackets indicate the total number of mosquitoes dissected 7 days post infection (dpi) for each sugar treatment. Different letters above the bars denote statistically significant differences based on multiple pair-wise post-hoc tests. (b) Infection intensity (± se), expressed as the mean number of developing oocysts in the guts of infected females, over 4 replicates and using a total of 7 gametocyte carriers. Numbers in brackets indicate the total number of infected mosquitoes for each sugar treatment. Different letters above the bars denote statistically significant differences based on multiple pair-wise post-hoc tests. (c) Survivorship of malaria-exposed mosquitoes for each sugar treatment over 4 replicates and using a total of 7 gametocyte carriers. Survival was recorded twice a day from 1 to 7 dpi. (d) Egg incidence (± 95% CI) of malaria-exposed mosquitoes, expressed as the proportion of mosquito females carrying fully matured eggs inside their ovaries on 7 dpi for each sugar treatment and infection status.</p