2,569 research outputs found
Strategies for proteomic analysis of blood glycated proteins
Comunicaciones a congreso
Labeling of bifidobacterium longum cells with 13C-substituted leucine for quantitative proteomic analyses
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Quantitative analysis of protein glycation in clinical samples
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The cell envelope proteome of bifidobacterium longum in a vitro bile environment
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Glycated platelets proteome
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Quaking RNA bindings proteins as mediator of oncolytic HSV vectors in huma hepatoma cells
Comunicaciones a congreso
The Most Massive Ultra-Compact Dwarf Galaxy in the Virgo Cluster
We report on the properties of the most massive ultra-compact dwarf galaxy
(UCD) in the nearby Virgo Cluster of galaxies using imaging from the Next
Generation Virgo Cluster Survey (NGVS) and spectroscopy from Keck/DEIMOS. This
object (M59-UCD3) appears to be associated with the massive Virgo galaxy M59
(NGC 4621), has an integrated velocity dispersion of 78 km/s, a dynamical mass
of , and an effective radius () of 25 pc. With an
effective surface mass density of , it is the
densest galaxy in the local Universe discovered to date, surpassing the density
of the luminous Virgo UCD, M60-UCD1. M59-UCD3 has a total luminosity of
mag, and a spectral energy distribution consistent with an old
(14 Gyr) stellar population with [Fe/H]=0.0 and [/Fe]=+0.2. We also
examine deep imaging around M59 and find a broad low surface brightness stream
pointing towards M59-UCD3, which may represent a tidal remnant of the UCD
progenitor. This UCD, along with similar objects like M60-UCD1 and M59cO,
likely represents an extreme population of tidally stripped galaxies more akin
to larger and more massive compact early-type galaxies than to nuclear star
clusters in present-day dwarf galaxies.Comment: 6 pages, 4 figures, 1 table, accepted for publication in ApJ Letter
Experimental Zika Virus Infection in the Pregnant Common Marmoset Induces Spontaneous Fetal Loss and Neurodevelopmental Abnormalities.
During its most recent outbreak across the Americas, Zika virus (ZIKV) was surprisingly shown to cause fetal loss and congenital malformations in acutely and chronically infected pregnant women. However, understanding the underlying pathogenesis of ZIKV congenital disease has been hampered by a lack of relevant in vivo experimental models. Here we present a candidate New World monkey model of ZIKV infection in pregnant marmosets that faithfully recapitulates human disease. ZIKV inoculation at the human-equivalent of early gestation caused an asymptomatic seroconversion, induction of type I/II interferon-associated genes and proinflammatory cytokines, and persistent viremia and viruria. Spontaneous pregnancy loss was observed 16-18 days post-infection, with extensive active placental viral replication and fetal neurocellular disorganization similar to that seen in humans. These findings underscore the key role of the placenta as a conduit for fetal infection, and demonstrate the utility of marmosets as a highly relevant model for studying congenital ZIKV disease and pregnancy loss
New insights into the genetic etiology of Alzheimer’s disease and related dementias
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique
opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage
genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk
loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau
pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive
of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain
assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from
mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the
lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
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