15 research outputs found
Estimation Files
Estimation of a temperature-dependent neural mass model from experimental data
Effect of <i>Q</i><sub>10,<i>syn</i></sub>.
<p>As <i>Q</i><sub>10,<i>syn</i></sub> is increased from unity, frequency of epileptic discharges during cooling (60 s–120 s) becomes less until complete termination. (From top to bottom: <i>Q</i><sub>10,<i>syn</i></sub> = 1.0, 1.007, 1.013, 1.085.)</p
Response functions and the effect of Q<sub>10</sub>.
<p>Different populations of neurons have different post-synaptic impulse response (solid lines, left) but are assumed to have the same firing response (solid line, right). <i>Q</i><sub>10,<i>syn</i></sub> scales down the post-synaptic impulse response curves (broken lines, left) while <i>Q</i><sub>10,<i>int</i></sub> changes the properties of the firing response curve (broken line, right).</p
Bifurcation with respect to <i>Q</i><sub>10,<i>int</i></sub> at different temperature and <i>Q</i><sub>10,<i>syn</i></sub> values.
<p>Region of bistability with respect to <i>Q</i><sub>10,<i>int</i></sub> vanishes at higher cooling temperatures (left). Similar bifurcation pattern is also observed at arbitrary <i>Q</i><sub>10,<i>syn</i></sub> values with T = 15°C (right). The colorbars indicate discharge magnitude in arbitrary units.</p
Bifurcation with respect to <i>Q</i><sub>10,<i>int</i></sub>.
<p>With <i>Q</i><sub>10,<i>syn</i></sub> = 1.8, magnitude and frequency of discharges exhibit bifurcation behavior with respect to <i>Q</i><sub>10,<i>int</i></sub> at different cooling temperatures. (From left to right: T = 15°C, 20°C, 25°C.)</p
Estimated values of the parameters for the model of discharge activity before cooling.
<p>Estimated values of the parameters for the model of discharge activity before cooling.</p
Estimated values of Q<sub>10</sub> factors from three different models.
<p>Estimated values of Q<sub>10</sub> factors from three different models.</p
Comparison of models.
<p>Boxplot of MAPE of different models from experimental data. (*<i>p</i> < 0.01, Wilcoxon signed rank test)</p
Simulated activity from rat 4.
<p>Suppression of epileptic discharges is replicated by the different models. (From top to bottom: Experimental data, SYN_INT, EXC_INH, EXC_SIN_FIN)</p
Neural mass model by Wendling et al.
<p>Block diagram of the model showing the interconnections among the neural populations (left) and the processes involved for each population (right).</p