Experimental Evidence for Using a TTM Stages of Change Model in Boosting Progress Toward 2FA Adoption

Behavior change ideas from health psychology can also help boost end user compliance with security recommendations, such as adopting two-factor authentication (2FA). Our research adapts the Transtheoretical Model Stages of Change from health and wellness research to a cybersecurity context. We first create and validate an assessment to identify workers on Amazon Mechanical Turk who have not enabled 2FA for their accounts as being in Stage 1 (no intention to adopt 2FA) or Stages 2-3 (some intention to adopt 2FA). We randomly assigned participants to receive an informational intervention with varied content (highlighting process, norms, or both) or not. After three days, we again surveyed workers for Stage of Amazon 2FA adoption. We found that those in the intervention group showed more progress toward action/maintenance (Stages 4-5) than those in the control group, and those who received content highlighting the process of enabling 2FA were significantly more likely to progress toward 2FA adoption. Our work contributes support for applying a Stages of Change Model in usable security.Comment: 41 pages, including the stage algorithm programmed on Mturk, the survey flow and specific items used, and a link to download the five informational handouts used for the control condition and the 2FA intervention condition

Negative Differential Resistance in the Scanning Tunneling Spectroscopy of Organic molecules

The conductance-voltage spectrum of molecular nanostructures measured by scanning tunneling spectroscopy (STS) is generally assumed to reflect the local density of states of the molecule. This excludes the possibility of observing negative differential resistance (NDR). We report here the observation of NDR in the scanning tunneling microscope (STM) current-voltage (I-V) characteristics of self-assembled monolayer (SAM) of 4-p-Terphenylthiol molecules on gold substrate measured using a platinum probe. We argue that the NDR arises from narrow structures in the local density of states at the tip apex atom and show that depending on the electrostatic potential profile across the system, NDR could be observed in one or both bias directions.Comment: 13 Pages, 4 figures, submitted to Phys. Rev. B Rapid Communicatio

Peekaboo: A Hub-Based Approach to Enable Transparency in Data Processing within Smart Homes (Extended Technical Report)

We present Peekaboo, a new privacy-sensitive architecture for smart homes that leverages an in-home hub to pre-process and minimize outgoing data in a structured and enforceable manner before sending it to external cloud servers. Peekaboo's key innovations are (1) abstracting common data pre-processing functionality into a small and fixed set of chainable operators, and (2) requiring that developers explicitly declare desired data collection behaviors (e.g., data granularity, destinations, conditions) in an application manifest, which also specifies how the operators are chained together. Given a manifest, Peekaboo assembles and executes a pre-processing pipeline using operators pre-loaded on the hub. In doing so, developers can collect smart home data on a need-to-know basis; third-party auditors can verify data collection behaviors; and the hub itself can offer a number of centralized privacy features to users across apps and devices, without additional effort from app developers. We present the design and implementation of Peekaboo, along with an evaluation of its coverage of smart home scenarios, system performance, data minimization, and example built-in privacy features.Comment: 18 page

The livehoods project: utilizing social Media to understand the dynamics of a city.

Abstract Studying the social dynamics of a city on a large scale has traditionally been a challenging endeavor, often requiring long hours of observation and interviews, usually resulting in only a partial depiction of reality. To address this difficulty, we introduce a clustering model and research methodology for studying the structure and composition of a city on a large scale based on the social media its residents generate. We apply this new methodology to data from approximately 18 million check-ins collected from users of a location-based online social network. Unlike the boundaries of traditional municipal organizational units such as neighborhoods, which do not always reflect the character of life in these areas, our clusters, which we call Livehoods, are representations of the dynamic areas that comprise the city. We take a qualitative approach to validating these clusters, interviewing 27 residents of Pittsburgh, PA, to see how their perceptions of the city project onto our findings there. Our results provide strong support for the discovered clusters, showing how Livehoods reveal the distinctly characterized areas of the city and the forces that shape them

Restriction of HIV-1 Genotypes in Breast Milk Does Not Account for the Population Transmission Genetic Bottleneck That Occurs following Transmission

BACKGROUND. Breast milk transmission of HIV-1 remains a major route of pediatric infection. Defining the characteristics of viral variants to which breastfeeding infants are exposed is important for understanding the genetic bottleneck that occurs in the majority of mother-to-child transmissions. The blood-milk epithelial barrier markedly restricts the quantity of HIV-1 in breast milk, even in the absence of antiretroviral drugs. The basis of this restriction and the genetic relationship between breast milk and blood variants are not well established. METHODOLOGY/PRINCIPAL FINDINGS. We compared 356 HIV-1 subtype C gp160 envelope (env) gene sequences from the plasma and breast milk of 13 breastfeeding women. A trend towards lower viral population diversity and divergence in breast milk was observed, potentially indicative of clonal expansion within the breast. No differences in potential N-linked glycosylation site numbers or in gp160 variable loop amino acid lengths were identified. Genetic compartmentalization was evident in only one out of six subjects in whom contemporaneously obtained samples were studied. However, in samples that were collected 10 or more days apart, six of seven subjects were classified as having compartmentalized viral populations, highlighting the necessity of contemporaneous sampling for genetic compartmentalization studies. We found evidence of CXCR4 co-receptor using viruses in breast milk and blood in nine out of the thirteen subjects, but no evidence of preferential localization of these variants in either tissue. CONCLUSIONS/SIGNIFICANCE. Despite marked restriction of HIV-1 quantities in milk, our data indicate intermixing of virus between blood and breast milk. Thus, we found no evidence that a restriction in viral genotype diversity in breast milk accounts for the genetic bottleneck observed following transmission. In addition, our results highlight the rapidity of HIV-1 env evolution and the importance of sample timing in analyses of gene flow.National Institute of Child Health and Human Development; National Institutes of Health (R01 HD 39611, R01 HD 40777); International Maternal Pediatric Adolescent AIDS Clinical Trials Group (U01 AI068632-01); National Institutes of Health Cellular, Biochemical; Molecular Sciences Training Program Grant (T 32 067587

Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome

Inflammasomes are important for host defence against pathogens and homeostasis with commensal microbes. Here, we show non-haemolytic enterotoxin (NHE) from the neglected human foodborne pathogen Bacillus cereus is an activator of the NLRP3 inflammasome and pyroptosis. NHE is a non-redundant toxin to haemolysin BL (HBL) despite having a similar mechanism of action. Via a putative transmembrane region, subunit C of NHE initiates binding to the plasma membrane, leading to the recruitment of subunit B and subunit A, thus forming a tripartite lytic pore that is permissive to efflux of potassium. NHE mediates killing of cells from multiple lineages and hosts, highlighting a versatile functional repertoire in different host species. These data indicate that NHE and HBL operate synergistically to induce inflammation and show that multiple virulence factors from the same pathogen with conserved function and mechanism of action can be exploited for sensing by a single inflammasome

Immunomodulation by imiquimod in patients with high-risk primary melanoma.

Imiquimod is a synthetic Toll-like receptor 7 (TLR7) agonist approved for the topical treatment of actinic keratoses, superficial basal cell carcinoma, and genital warts. Imiquimod leads to an 80-100% cure rate of lentigo maligna; however, studies of invasive melanoma are lacking. We conducted a pilot study to characterize the local, regional, and systemic immune responses induced by imiquimod in patients with high-risk melanoma. After treatment of the primary melanoma biopsy site with placebo or imiquimod cream, we measured immune responses in the treated skin, sentinel lymph nodes (SLNs), and peripheral blood. Treatment of primary melanomas with 5% imiquimod cream was associated with an increase in both CD4+ and CD8+ T cells in the skin, and CD4+ T cells in the SLN. Most of the CD8+ T cells in the skin were CD25 negative. We could not detect any increases in CD8+ T cells specifically recognizing HLA-A(*)0201-restricted melanoma epitopes in the peripheral blood. The findings from this small pilot study demonstrate that topical imiquimod treatment results in enhanced local and regional T-cell numbers in both the skin and SLN. Further research into TLR7 immunomodulating pathways as a basis for effective immunotherapy against melanoma in conjunction with surgery is warranted

Beneficial Betrayal Aversion

Many studies demonstrate the social benefits of cooperation. Likewise, recent studies convincingly demonstrate that betrayal aversion hinders trust and discourages cooperation. In this respect, betrayal aversion is unlike socially “beneficial” preferences including altruism, fairness and inequity aversion, all of which encourage cooperation and exchange. To our knowledge, other than the suggestion that it acts as a barrier to rash trust decisions, the benefits of betrayal aversion remain largely unexplored. Here we use laboratory experiments with human participants to show that groups including betrayal-averse agents achieve higher levels of reciprocity and more profitable social exchange than groups lacking betrayal aversion. These results are the first rigorous evidence on the benefits of betrayal aversion, and may help future research investigating cultural differences in betrayal aversion as well as future research on the evolutionary roots of betrayal aversion. Further, our results extend the understanding of how intentions affect social interactions and exchange and provide an effective platform for further research on betrayal aversion and its effects on human behavior